雌激素,随意皮瓣,血管生成,成活面积," /> 雌激素,随意皮瓣,血管生成,成活面积,"/> An experimental study of the effects of estrogen on random flap survival
Int J Stomatol

Inter J Stomatol ›› 2010, Vol. 37 ›› Issue (6): 634-636.doi: 10.3969/j.issn.1673-5749.2010.06.004

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An experimental study of the effects of estrogen on random flap survival

Ji-yuan1, ZHANG Fu-gui1,YUAN Meng-jiang1, TANG Xiu-fa2.   

  1. 1. State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041,China; 2. Dept. of Head and Neck Tumor Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China
  • Online:2010-11-20 Published:2010-11-20

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Abstract:

Objective The purpose of this experimental study is to explore the effects of estrogen in survival of random flaps. Methods Eighteen female SD rats were divided into three groups randomly, namely the 100 and 300 μg·kg－1 groups, control group. The experimental models of ultra-length-and-width random flap on rats’back were established, and the ones of experimental groups were injected with estrogen at the distal part of the flaps.The microvessel density and survival area of the random flaps in three groups were tested at different time points.Results The MVD and survival area of 100 μg·kg－1 group are better than those of control group and 300 μg·kg－1 group. Conclusion Proper dose of estrogen can promote angiogenesis of random flaps, and improve the survival area of random flaps.

Key words: estrogen, random flap, angiogenesis, survival area


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