Int J Stomatol

Inter J Stomatol ›› 2019, Vol. 46 ›› Issue (1): 30-36.doi: 10.7518/gjkq.2019.01.006

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Advancements in receptor activity-modifying protein-1 for osteogenesis

Qin Zhang,Ping Gong()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Implantation, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-05-24 Revised:2018-07-19 Online:2019-01-01 Published:2019-01-11
  • Contact: Ping Gong E-mail:dentistgong@hotmail.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81571008);This study was supported by National Natural Science Foundation of China(81701007);Sichuan Science and Technology Program(2018RZ0087);the Fundamental Research Funds for the Central Universities(2017SCU-12056);the Fundamental Research Funds for the Central Universities(2018SCUH0006);Project Funded by China Postdoctoral Science Foundation(2018M-631091);the Youth Science Foundation of West China Hospital of Stomatology of Sichuan University(2016-11)

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Abstract:

Under physiological conditions, the dynamic balance between bone resorption and bone formation is necessary to maintain bone tissue function. However, whether we can further accelerate or improve osteogenesis process during bone wound healing has been widely explored. Receptor activity-modifying protein-1 (RAMP1) has been extensively investigated because of its extensive biological activities, especially its effects on bone fracture repair. RAMP1 is commonly found in bone tissues and can interact with G-protein coupled receptors to modify their activities. RAMP1 also has a broader role in regulating receptor trafficking and signaling, affecting the biological characteristics of osteoblasts, such as proliferation, migration, and differentiation. Thus, this review summarizes recent studies about the effects of RAMP1 on osteogenesis.

Key words: receptor activity-modifying protein-1, calcitonin gene-related peptide, osteogenesis, G-protein coupled receptor, calcitonin receptor-like receptor

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  • Q51

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Tab 1

Summary of the receptors that RAMPs have been involved in"

受体名称 受体主要分子组成
CGRP受体 CLR+RAMP1
AM1受体 CLR+RAMP2/3
AM2受体 CLR+RAMP1/2/3
AMY受体 CTR+RAMP1/2/3
VPAC受体 VPAC受体+RAMP1/2/3
PTH1受体 PTH1受体+RAMP2
PTH2受体 PTH2受体+RAMP3
CaSR CaSR+RAMP1/2/3

Fig 1

RAMP1 modulation of CGRP-mediated activities in osteogenesis"

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