Int J Stomatol

Int J Stomatol ›› 2025, Vol. 52 ›› Issue (6): 832-838.doi: 10.7518/gjkq.2025099

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Research progress on the correlation between mental illness and periodontal diseases

Yingying Lian(),Lei Zhao()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Periodontology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2024-11-01 Revised:2024-12-17 Online:2025-11-01 Published:2025-10-23
  • Contact: Lei Zhao E-mail:lianyingy2024@163.com;jollyzldoc@163.com
  • Supported by:
    Sichuan Natural Science Foundation Project(2023NSFSC0553)

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Abstract:

In recent years, with the rising pressure faced by people, mental health problems have become progressively conspicuous. The prevalence of mental illness has been increasing annually on a global scale, and its potential role in perio-dontal disease development has gradually attracted academic attention. Abnormal mental states can initiate various physiological responses, including hypothalamic-pituitary-adrenal axis over-activation, autonomic nervous system imbalance, and immune system dysfunction. These responses are involved in the regulation of periodontal tissue health by affecting bone formation, bacterial virulence, vascular function, and immune responses. Furthermore, numerous studies have indicated that the use of psychotropic medications has a certain impact on periodontal health. However, current research on the relationship and mechanisms between the two remains limited. This study systematically elucidates the multifaceted mechanisms through which mental disorders regulate periodontal health via the neuro-endocrine-immune network. It also incorporates psychotropic medications into the therapeutic discourse on periodontal disease management. The findings aim to provide a theoretical foundation for developing interdisciplinary prevention and treatment strategies integrating mental and oral healthcare.

Key words: mental illness, periodontal disease, hypothalamic-pituitary-adrenal axis, pathogenesis

CLC Number: 

  • R781.4

TrendMD: 
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