Int J Stomatol ›› 2025, Vol. 52 ›› Issue (1): 42-49.doi: 10.7518/gjkq.2025005

• Oral Oncology • Previous Articles     Next Articles

Current status of speech function after oral cancer surgery and analysis of influencing factors

Mei Wu1(),Yanjing Liang1,Xuepei Peng2,Weihong Chen2,Xingtong Guo2,Lili Hou3()   

  1. 1.Shanghai Jiao Tong University School of Nursing, Shanghai 200025, China
    2.School of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
    3.Dept. of Nursing, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
  • Received:2024-02-04 Revised:2024-08-06 Online:2025-01-01 Published:2025-01-11
  • Contact: Lili Hou E-mail:583512378@qq.com;pisces_liz@163.com
  • Supported by:
    Shanghai Shenkang Hospital Development Center Municipal Hospital Diagnosis and Treatment Technology Promotion and Optimization Management Project(SHDC22023238)

Abstract:

Objective This study aims to explore the development trends, research hotspots, and future directions of smart healthcare for oral cancer through bibliometrics, providing a reference for subsequent research. Methods English literature on smart healthcare for oral cancer in Web of Science Core Collection, Scopus, and PubMed databases and Chinese literature on the same topic in the CNKI database published in 2003-2023 were retrospectively collected. Meanwhile, the evidence-based visualization and comparative analysis of the countries, institutions, authors, citation frequency, and keywords included in the literature were performed with VOSviewer 1.6.18 software. Results A total of 547 English articles and 34 Chinese documents were included. An increasing trend in publication volume, especially in recent years, was observed. Among countries, the United States was the largest contributor to the field and had close academic exchanges with other countries, whereas cross-border, cross-institutional, and cross-team cooperation was limited in China. Moreover, network structure had regional characteri-stics. In addition, the artificial intelligence-assisted diagnosis and treatment of oral cancer are a common focus of attention in domestic and foreign literature. English literature focuses on the deep exploration of new diagnostic technologies, whereas Chinese literature tends to explore the application of intelligent health care and traditional Chinese medicine network pharmacology. Conclusion The conti-nuous development of smart healthcare for oral cancer has made the research on its application in artificial intelligence-assisted diagnosis, intelligent health care, and traditional Chinese medicine pharmacology increasingly profound. Early warning screening urgently needs to become an important focus of smart healthcare for oral health.Objective This study aimed to investigate the status of speech function in postoperative patients with oral cancer and analyze the factors affecting speech function. Methods A total of 180 patients who were admitted Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine from December 31, 2021 to March 31, 2023 and met the inclusion criteria were selected as the study subjects. The general information and clinical data questionnaire, Speech Handicap Index (SHI), Speech Articulation Word Scale, Hospital Anxiety and Depression Scale (HADS), Family Apgar Index (FAI), and Social Support Rating Scale (SSRS) were used. Results After oral cancer surgery, the proportion of speech disorder was 70%, and the proportion of speech articulation decreased by 61%. The results of step-by-step linear regression analysis showed that the Hospital Anxiety and Depression Scale-Depression (HADS-D; P=0.009), FAI (P=0.004), SSRS (P=0.039), and radiotherapy (P=0.019) scores entered the regression equation. The total variation in SHI score after oral cancer surgery was explained by 63.8%. T stage (P=0.001), income (P=0.007), alcohol consumption (P=0.001), tumor site (P=0.001), and SSRS (P=0.013) were included in the regression equation, accounting for 55.3% of the total variation in speech articulation after oral cancer surgery.Conclusion More than half of the patients with postoperative oral cancer have different degrees of impaired speech function, and early prevention, assessment, and intervention for patients should be performed with subjective and objective factors.

Key words: oral cancer, postoperative, speech function, status survey, influencing factors

CLC Number: 

  • R730.7

TrendMD: 

Tab 1

Information on general demographic and clini-cal characteristics"

变量构成/n(%)
性别
128(71)
52(29)
年龄/岁
<60144(80)
≥6036(20)
工作
在职120(67)
无业60(33)
教育程度
中学或以下27(15)
高中或中专120(67)
大学及以上33(18)
收入/(元/月)
<5 00079(44)
≥5 000101(56)
婚姻
单身/离异/丧偶8(4)
已婚/复婚172(96)
吸烟
77(43)
103(57)
饮酒
65(36)
115(64)
T分期
1~2106(59)
3~455(31)
远处转移
16(9)
164(91)
肿瘤部位
舌体86(48)
舌根29(16)
颊部14(8)
牙龈29(16)
硬腭5(3)
口底14(8)
3(1)
复发
16(9)
164(91)
术后时间/月
3~632(18)
6~1263(35)
>1285(47)
皮瓣
115(64)
65(36)
术后牙缺损
58(32)
122(68)
舌缺损范围
半舌84(56)
全舌18(12)
48(32)
张口度
正常/Ⅰ161(89)
Ⅱ/Ⅲ19(11)
放射治疗
110(61)
70(39)

Tab 2

One-way analysis of variance"

变量SHI得分语音清晰度
均值标准差F值/tP均值标准差F值/tP
性别
25.4925.63-0.0100.8890.800.28-0.1160.170
26.0025.550.810.24
年龄/岁
<6025.8025.170.1500.7790.820.251.0700.015
≥6025.0027.320.760.33
工作
在职26.0023.730.0300.9700.830.241.6610.194
无业24.9230.880.820.27
教育程度
中学或以下22.5425.711.7360.1800.890.187.8530.001
高中或中专28.2627.110.750.30
大学及以上18.7117.410.950.08
收入/(元/月)
<5 00027.6328.290.8480.0530.740.29-2.8730.003
≥5 00024.0723.180.860.23
婚姻
单身/离异 /丧偶43.5028.132.0560.8440.720.21-0.9320.397
已婚/复婚24.6325.110.810.27
吸烟
26.0926.140.1870.4080.790.27-0.5920.316
25.3025.220.820.26
饮酒
28.3026.060.9550.1510.750.30-2.0770.028
24.1525.240.840.24
T 分期
1~214.2015.179.152<0.0010.980.039.417<0.001
3~432.0026.080.630.31
远处转移
54.4333.344.4410.0370.600.36-3.0700.001
22.6822.750.830.25
肿瘤部位
舌体22.2222.242.8770.0110.870.152.9030.013
舌根42.6728.370.670.37
颊部16.0022.000.920.10
牙龈19.6726.700.790.35
硬腭35.0018.480.600.42
口底24.8327.360.720.36
36.5033.230.780
复发
51.0735.064.2010.0010.600.36-3.0700.001
22.6822.750.830.25
术后时间/月
3~621.2121.330.5480.5790.870.221.0840.341
6~1225.0824.130.780.29
>1227.1627.820.80.26
皮瓣
29.2225.252.5490.2610.780.26-1.6270.804
18.4124.360.850.27
术后牙缺损
20.3824.29-1.6480.1010.780.31-0.9500.010
27.6625.680.820.24
舌缺损范围
半舌23.8122.983.9410.0220.850.215.8090.004
全舌40.6730.380.620.32
22.2325.960.790.31
张口度
正常/Ⅰ24.4725.692.5580.0570.820.261.2320.300
Ⅱ/Ⅲ38.2317.830.730.31
放射治疗
32.6126.1294.730<0.0010.740.29-4.036<0.001
13.7819.3450.910.17

Tab 3

Correlation analysis of SHI and speech intelligibility"

测量项目均值标准差SHI语音清晰度
SHI25.33025.3901-0.646**
语音清晰度0.8100.267-0.646**1
HADS7.0606.8900.708**-0.508**
HADS-A2.7102.8600.718**-0.540**
HADS-D4.3504.2400.665**-0.460**
FAI8.0902.150-0.370**0.184*
SSRS38.0706.990-0.473**0.404**

Tab 4

Multiple linear regression analysis of SHI"

变量BSEBetatP共线性统计
容忍度方差膨胀因子
HADS-D1.7020.6620.1712.0600.0090.1995.032
FAI-1.7840.612-0.151-2.9150.0040.9031.107
SSRS2.1801.0470.1852.0820.0390.2813.554
放射治疗-6.4662.719-0.124-2.3780.0190.8871.127

Tab 5

Multiple linear regression analysis of speech intelligibility"

变量BSEBetatP共线性统计
容忍度方差膨胀因子
T分期-0.0500.014-0.218-3.5280.0010.7891.268
饮酒0.1080.0310.1953.4450.0010.9401.064
SSRS0.0060.0020.1582.5170.0130.7631.310
肿瘤部位-0.0300.009-0.194-3.2750.0010.8571.166
1 Global Burden of Disease 2019 Cancer Collaboration, Kocarnik JM, Compton K,et al. Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019: a systematic ana-lysis for the global burden of disease study 2019[J]. JAMA Oncol, 2022, 8(3): 420-444.
2 郑家伟, 李金忠, 涂文勇, 等. 口腔颌面部恶性肿瘤治疗指南[J]. 中国口腔颌面外科杂志, 2010, 8(2): 98-106.
Zheng JW, Li JZ, Tu WY, et al. The protocol of treatment guideline of oral and maxillofacial malignant neoplasms[J]. China J Oral Maxillofac Surg, 2010, 8(2): 98-106.
3 Balaguer M, Pommée T, Farinas J, et al. Effects of oral and oropharyngeal cancer on speech intelligibi-lity using acoustic analysis: systematic review[J]. Head Neck, 2020, 42(1): 111-130.
4 Matsui Y, Ohno K, Yamashita Y, et al. Factors in-fluencing postoperative speech function of tongue cancer patients following reconstruction with fasciocutaneous/myocutaneous flaps-a multicenter study[J]. Int J Oral Maxillofac Surg, 2007, 36(7): 601-609.
5 Yanai C, Kikutani T, Adachi M, et al. Functional outcome after total and subtotal glossectomy with free flap reconstruction[J]. Head Neck, 2008, 30(7): 909-918.
6 Badr H, Lipnick D, Gupta V, et al. Survivorship challenges and information needs after radiotherapy for oral cancer[J]. J Cancer Educ, 2017, 32(4): 799-807.
7 Lee YC, Wong TY, Shieh SJ, et al. Trismus release in oral cancer patients[J]. Ann Plast Surg, 2012, 69(6): 598-601.
8 Rinkel RN, Verdonck-de Leeuw IM, van Reij EJ, et al. Speech Handicap Index in patients with oral and pharyngeal cancer: better understanding of patients’ complaints[J]. Head Neck, 2008, 30(7): 868-874.
9 吴沛霞, 姚晴, 王韦, 等. 中文版言语障碍指数量表的信效度评价[J]. 护理学杂志, 2014, 29(18): 28-31.
Wu PX, Yao Q, Wang W, et al. Reliability and validation of Chinese version of speech handicap index[J]. J Nurs Sci, 2014, 29(18): 28-31.
10 王国民, 朱川, 袁文化, 等. 汉语语音清晰度测试字表的建立和临床应用研究[J]. 上海口腔医学, 1995, 4(3): 125-127, 183.
Wang GM, Zhu C, Yuan WH, et al. Establishment and clinical application of chinese language clear degree[J]. Shanghai J Stomatol, 1995, 4(3):125-127, 183.
11 Smarr KL, Keefer AL. Measures of depression and depressive symptoms: beck depression inventory-Ⅱ (BDI-Ⅱ), center for epidemiologic studies depression scale (CES-D), geriatric depression scale (GDS), hospital anxiety and depression scale (HADS), and patient health questionnaire-9 (PHQ-9)[J]. Arthritis Care Res (Hoboken), 2011, 63(): S454-S466.
12 叶维菲, 施寿康, 徐俊冕, 等. 957例住院病人焦虑、抑郁障碍的研究[J]. 中国行为医学科学, 1995, 4(4): 198-199, 222.
Ye WF, Shi SK, Xu JM, et al. A study on anxiety and depressive disorders in 957 cases of inpatients[J]. Chin J Behav Med Brain Sci, 1995, 4(4): 198-199, 222.
13 Smilkstein G, Ashworth C, Montano D. Validity and reliability of the family APGAR as a test of family function[J]. J Fam Pract, 1982, 15(2): 303-311.
14 肖水源. 《社会支持评定量表》的理论基础与研究应用[J]. 临床精神医学杂志, 1994, 4(2): 98-100.
Xiao SY. Theoretical basis and research application of the Social Support Rating Scale[J]. J Clin Psychia-try, 1994, 4(2): 98-100.
15 Ringash J, Bernstein LJ, Devins G, et al. Head and neck cancer survivorship: learning the needs, mee-ting the needs[J]. Semin Radiat Oncol, 2018, 28(1): 64-74.
16 Strojan P, Hutcheson KA, Eisbruch A, et al. Treatment of late sequelae after radiotherapy for head and neck cancer[J]. Cancer Treat Rev, 2017, 59: 79-92.
17 Zhang MJ, Mu JW, Chen XR, et al. Effect of voice rehabilitation training on the patients with laryngeal cancer after radiotherapy[J]. Medicine (Baltimore), 2018, 97(26): e11268.
18 Davies-Husband C, Murphy J, Kelly C, et al. Extreme long-term voice outcomes after concurrent chemoradiotherapy for advanced non-laryngeal head and neck cancer: eight-year post-treatment analysis[J]. Clin Otolaryngol, 2018, 43(6): 1494-1499.
19 Riechelmann H, Dejaco D, Steinbichler TB, et al. Functional outcomes in head and neck cancer patients[J]. Cancers (Basel), 2022, 14(9): 2135.
20 Piai V, Jansen F, Dahlslätt K, et al. Prevalence of neurocognitive and perceived speech deficits in patients with head and neck cancer before treatment: associations with demographic, behavioral, and di-sease-related factors[J]. Head Neck, 2022, 44(2): 332-344.
21 Dahill A, Al-Nakishbandi H, Cunningham KB, et al. Loneliness and quality of life after head and neck cancer[J]. Br J Oral Maxillofac Surg, 2020, 58(8): 959-965.
22 Chen YW, Lin TR, Kuo PL, et al. Psychosocial adjustment changes and related factors in postoperative oral cancer patients: a longitudinal study[J]. Biomedicines, 2022, 10(12): 3231.
23 Wu YS, Lin PY, Chien CY, et al. Anxiety and depression in patients with head and neck cancer: 6-month follow-up study[J]. Neuropsychiatr Dis Treat, 2016, 12: 1029-1036.
24 Böhm N, Knipfer C, Maier A, et al. Speech ability and psychological outcome after treatment of oral cancer[J]. Laryngorhinootologie, 2016, 95(9): 610-619.
25 Eadie T, Faust L, Bolt S, et al. Role of psychosocial factors on communicative participation among survivors of head and neck cancer[J]. Otolaryngol Head Neck Surg, 2018, 159(2): 266-273.
26 Zarek A, Halczy-Kowalik L, Rzewuska A, et al. Psychological characteristics versus swallowing and speech rehabilitation efficiency in patients after oral cavity cancer excision[J]. Pomeranian J Life Sci, 2016, 62(4): 5-17.
27 Singer S, Krauss O, Keszte J, et al. Predictors of emotional distress in patients with head and neck cancer[J]. Head Neck, 2012, 34(2): 180-187.
28 Bingo SAM, Maree JE, Jansen van Rensburg JJM. Living with cancer of the head and neck: a qualitati-ve inquiry into the experiences of South African patie-nts[J]. Eur J Cancer Care (Engl), 2020, 29(2): e13205.
29 Schorn L, Lommen J, Sproll C, et al. Evaluation of patient specific care needs during treatment for head and neck cancer[J]. Oral Oncol, 2020, 110: 104898.
30 van der Molen L, van Rossum MA, Burkhead LM, et al. A randomized preventive rehabilitation trial in advanced head and neck cancer patients treated with chemoradiotherapy: feasibility, compliance, and shor-tterm effects[J]. Dysphagia, 2011, 26(2): 155-170.
31 Kraaijenga SA, Oskam IM, van Son RJ, et al. Assessment of voice, speech, and related quality of life in advanced head and neck cancer patients 10-years+ after chemoradiotherapy[J]. Oral Oncol, 2016, 55: 24-30.
32 Eadie TL, Lamvik K, Baylor CR, et al. Communicative participation and quality of life in head and neck cancer[J]. Ann Otol Rhinol Laryngol, 2014, 123(4): 257-264.
33 Fletcher BS, Schumacher K, Cohen MZ, et al. Understanding functional communication in head and neck cancer survivors using a mixed methods design[J]. Cancer Nurs, 2019, 42(2): 119-128.
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