Int J Stomatol

Int J Stomatol ›› 2023, Vol. 50 ›› Issue (2): 217-223.doi: 10.7518/gjkq.2023038

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Research progress on the genes related of the hereditary gingival fibromatosis

Qiao Yuxuan1(),Li Ying1,2()   

  1. 1.Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, China
    2.Dept. of Prosthodontics, The First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2022-07-27 Revised:2022-10-04 Online:2023-03-01 Published:2023-03-14
  • Contact: Ying Li E-mail:2356230680@qq.com;Oliver1104@163.com

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Abstract:

Hereditary gingival fibromatosis (HGF) is a rare oral genetic disease characterized by slow progressive gingival proliferation, which seriously affects chewing, speech, aesthetics and mental health. In recent years, with the deve-lopment of molecular biology and continuous progress of sequencing technology, the study of hereditary gingival fibromatosis has entered the genetic level. At present, the pathogenic mechanism of hereditary gingival fibromatosis is notentirelyclear. Meanwhile, there are a lot of results in the exploration of the pathogenic genes of hereditary gingival fibromatosis at home and abroad, but there is a lack of collation and review of relevant aspects. This paper reviews the research status of chromosomal variation regions, pathogenic genes and candidate genes in hereditary.

Key words: hereditary gingival fibromatosis, chromosome, gene, research progress, genetic disease

CLC Number: 

  • R 34

TrendMD: 

Tab 1

Pathogenic genes associated with SHGF"

疾病名称遗传特性#致病基因染色体定位OMIM△编号
HTC1ARABCA517q24.2-q24.3135400
HTC2XLD—Xq27.1307150
CavipmrAREMC11p36.13616875
DRS2ADDVL11p36.33616331
Ramon综合征AR——266270
HFSARANTXR24q21.21228600
Cowden综合征ADPTEN10q23.31158350
Cross综合征AR——257800
MANSAARMAN2B119p13.13248500
CSTLOADHRAS11p15.5218040
黏脂贮积症Ⅱ型ARIDUA4p16.3607014
遗传性釉质发育不全ⅢAADFAM83H8q24.3130900
遗传性釉质发育不全ⅠBADENAM4q13.3104500
SHFM1ADDLX57q21.3183600
多诺霍综合征ARINSR19p13.2147670
CFSMRARTMCO11q24.1213980
DRS3ADDVL33q27.1601368
AGUARAGA4q34.3208400
FTHSARSH3PXD2B5q35.1249420
EDSDERMSARADAMTS25q35.3225410
纤溶酶原缺乏Ⅰ型ARPLG6q26217090
ZLS1ADKCNH11q32.2135500
ZLS2ARATP6V1B28p21.3616455
RNSARFAM20C7p22.3259775
RRS1ARROR29q22.31268310
BBDSADFGFR210q26.13614592
CANTU综合征ADABCC912p12.1239850
MONAARMMP216q12.2259600

"

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