Int J Stomatol

Inter J Stomatol ›› 2017, Vol. 44 ›› Issue (4): 477-483.doi: 10.7518/gjkq.2017.04.021

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Research on Candida albicans in the denture stomatitis

Zhou Yujie, Ren Biao, Cheng Lei, Zhou Xuedong   

  1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2016-12-01 Revised:2017-02-22 Online:2017-07-01 Published:2017-07-01
  • Supported by:
    This study was supported by the National Natural Science Foundation of China(81430011).

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Abstract: Denture stomatitis is a common disorder affecting denture wearers. The typical symptom of denture stomatitis is characterized as inflammation and erythema of the oral mucosal areas covered by the denture. However, the etiology of denture stomatitis is not completely understood. A large number of surveys have shown a strong link between Candida albicans and denture stomatitis. Basically, the C. albicans pathogenicity included different factors: adhesins, secreted enzymes, and the diversity of morphological. The virulence factors involved in the pathogenic procedures are usually mediated by one or more signal pathways of correlated genes. The aim of this paper is to review current understanding on the roles of C. albicans and its virulence factors during the denture stomatitis development, as well as the reactions of host cells when infected by C. albicans.

Key words: Candida albicans, denture stomatitis, virulence factor

CLC Number: 

  • R781.5

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