Int J Stomatol

Inter J Stomatol ›› 2016, Vol. 43 ›› Issue (2): 244-248.doi: 10.7518/gjkq.2016.02.028

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The function of the WD40-encoding RNA antisense to P53 and protein

Lu Wenxin, Ge Yichen, Xiao Liying, Li Yan   

  1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China)
  • Received:2015-06-01 Revised:2015-10-19 Online:2016-03-01 Published:2016-03-01

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Abstract: WD40-encoding RNA antisense to P53 has three exons:1α, 1β, and 1γ. The exon 1α of WRAP53 directly overlaps the first exon of P53 in an antisense way. The WRAP53 1α transcript could regulate the level of P53 RNA, and then induce the expression of the P53 protein. The biological behavior of tumor could be regulated by P53 protein. The exon 1β of WRAP53 produces a protein called WRAP53 protein, which is associated with programmed cell death, cycle regulation, protease degradation and RNA metabolism. WRAP53 protein contacts with various components of telomerase, helps the telomerase to locate in Cajal body(CB) and is an essential factor for CB formation, maintenance and the location of survival motor neuron. WRAP53 has a high expression in tumor cell and clinical tumor sample. The higher the expression of WRAP53 is, the worse of the prognosis of tumor will be. Silencing the WRAP53 can inhibit the growth of tumor cell. Dyskeratosis congenital is related to the shortage of the length of telomere which is owing to the low expression of WRAP53.

Key words: WD40-encoding RNA antisense to P53, telomerase Cajal body protein, telomere, protein, WD40-encoding RNA antisense to P53, telomerase Cajal body protein, telomere, protein

CLC Number: 

  • Q 786

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（本文采编 王晴）
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