Int J Stomatol ›› 2019, Vol. 46 ›› Issue (3): 263-269.doi: 10.7518/gjkq.2019034

• Signalling Pathways • Previous Articles     Next Articles

Research progress on role of Hippo pathway in bone metabolism

Xinyuan Zhang,Bin Wang,Hui Yu,Liwen Zhu,Lin Xiang()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-05-22 Revised:2019-01-16 Online:2019-05-01 Published:2019-06-05
  • Contact: Lin Xiang
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81701007);Sichuan Science and Technology Program(2018RZ0087);Fundamental Research Funds for the Central Universities(2017SCU12056);Fundamental Research Funds for the Central Universities(2018SCUH0006);China Postdoctoral Science Foundation(2018M631091);Youth Science Foundation of West China Hospital of Stomatology of Sichuan University(2016-11)


In mammals, the Hippo signalling pathway is highly conserved and regulates bone metabolism and maintains the essential physiological functions of bones. Mammalian sterile 20-like kinase 1/2, large tumour suppressor 1/2 and the Yes-associated protein/transcriptional coactivator with PDZ-binding motif are the core components of the Hippo signalling pathway. This pathway mediates the physiological functions of osteoblasts, osteoclasts and chondrocytes under the regulation of multiple transcription factors upstream and downstream. In this study, we highlight the recent research progress on the mechanism underlying bone metabolism in the Hippo signalling pathway. We hope that this review can provide new ideas and strategies for further investigations and treatment of bone metabolism-related diseases.

Key words: Hippo signaling pathway, mammalian sterile 20-like kinase, Yes associated protein, bone metabolism

CLC Number: 

  • Q257

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