Int J Stomatol

Inter J Stomatol ›› 2012, Vol. 39 ›› Issue (4): 428-431.doi: 10.3969/j.issn.1673-5749.2012.04.002

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The effect of tobacco smoke on the expression of the dentin matrix protein 1 C-terminal in rat alveolar bone

Hou Xiumin1, Ma Su1, Liu Peihong1, Qin Chunlin2, Chen Li2.   

  1. 1. Dept. of Periodontics, Hospital of Stomatology, Harbin Medical University, Harbin 150001, China； 2. Heilongjiang Scholars Laboratory, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
  • Received:2011-10-12 Revised:2012-04-16 Online:2012-07-01 Published:2012-07-01

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Abstract:

Objective To observe the effect of tobacco smoke on the expression of the dentin matrix protein （DMP）1 C-terminal in rat alveolar bone. Methods The model of the test rats inhaled tobacco smoke was established. The expression of the DMP1 C-terminal in the alveolar bone was detected by immunohistochemistry. Results Control group: DMP1 C-terminal continuous linear expressed in the calcification front of the proper alveolar bone and it is dark brown yellow, apparent mineralization strap was formed; DMP1 C-terminal brown granular dense clouded around the bone cells and light brown yellow fine granules scattered in the mineralized zone; the expression of the DMP1 C-terminal gradually increased from the alveolar ridge crest to root tip. Experimental group: DMP1 C-terminal parts of the same expression in the control group, decreased intensity of expression, this change increased with prolonged test time. Conclusion Inhalation of tobacco smoke can decrease the expression of the DMP1 C-terminal in rat alveolar bone. The effect presents time dependent in this study period.

Key words: tobacco smoke, alveolar bone, mineralization, dentin matrix protein


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