Int J Stomatol

Inter J Stomatol ›› 2011, Vol. 38 ›› Issue (5): 539-541.doi: 10.3969/j.issn.1673-5749.2011.05.012

Previous Articles     Next Articles

Epithelial—mesenchymal transformation and association with chemoresistace in head and neck cancer

Cai Weixin, Huang Hongzhang.   

  1. Dept. of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou 510055, China
  • Received:2010-07-13 Revised:2011-03-15 Online:2011-09-20 Published:2011-09-20

RichHTML

3

PDF (PC)

1836

Abstract:

The differentiated epithelial cells could be transformed into mesenchymal cells through a cellular program named epithelial—mesenchymal transformation（EMT）, which plays an important role in development, carcinoma invasion and also chemoresistance. Since chemoresistance always cause the failure of chemotherapy, to overcome chemoresistance is key to maintain the effectiveness of chemotherapy. This article reviews EMT and its biological significance, its association with chemoresistace, especially in head and neck cancer.

Key words: epithelial—mesenchymal transformation, chemoresistance, tumor


TrendMD: 
[1] Wu Jiamin,Xia Bin,Yang Hefeng,Xu Biao.. Research progress on cancer-associated fibroblasts in the tumor microenvironment of oral squamous cell carcinoma [J]. Int J Stomatol, 2023, 50(6): 711-717.
[2] Zhao Lingfan, Zhou Yang, Ye Xinxin, Zhang Qiang.. Poorly differentiated mucoepidermoid carcinoma of the parotid gland after renal transplantation: a case report [J]. Int J Stomatol, 2023, 50(4): 419-422.
[3] Zhang Chaoying,Li Yining,Gong Jiaxing,Wang Huiming. Interpretation of the 2022 classification of head and neck tumors by the World Health Organization: odontogenic and maxillofacial bone tumors [J]. Int J Stomatol, 2023, 50(3): 263-271.
[4] Sheng Nanning,Wang Jue,Nan Xinrong. Research progress on mechanism and treatment of sex-determining region Y box 9 in oral squamous cell carcinoma [J]. Int J Stomatol, 2023, 50(3): 314-320.
[5] Li Tan,Liang Xin-hua.. Role of discoidin domain receptor 1 in the regulation of malignant tumor progression and therapy [J]. Int J Stomatol, 2023, 50(2): 230-236.
[6] Luo Wanyi,Han Juxi,Zhou Xuedong,Peng Xian,Zheng Xin. Research progress on the mechanism of Fusobacterium nucleatum promoting the initiation and development of colorectal cancer [J]. Int J Stomatol, 2023, 50(1): 52-60.
[7] Gan Jianguo,Gao Pan,Wang Xiaoyi. Research progress on the relationship between circulating tumor cells and oral squamous cell carcinoma [J]. Int J Stomatol, 2021, 48(2): 205-212.
[8] Cui Yujia,Sun Jianxun,Zhou Xuedong. Progress for understanding the effect of berberine in oral diseases [J]. Int J Stomatol, 2020, 47(1): 115-120.
[9] Yue Shijing,Qing Yifan,Lin Jie,Han Bo. Effects of spleen tyrosine kinase and its related signalling pathways on the development of head and neck tumors and their mechanisms [J]. Int J Stomatol, 2019, 46(4): 442-449.
[10] Tongtong Han,Qiaoer Chen,Youming. Zhu. Long non-coding RNA associated with p53 and the relationship with tumor [J]. Inter J Stomatol, 2018, 45(5): 597-602.
[11] Wang Zhiqiang, Ma Lijuan, Zhou Haijing, Yang Lan, Nie Hongbing, Xue Long. Research progress on antitumor effect and mechanism of probiotics [J]. Inter J Stomatol, 2017, 44(6): 636-641.
[12] Liang Jing, Wang Kai, Wu Jiayuan. Research progress on CD24 in stomatology [J]. Inter J Stomatol, 2017, 44(5): 608-613.
[13] Niu Haoman, Zhang Lina, Yang Xiao, Tang Yaling, Geng Ning, Chen Yu.. Malignant transformation of keratocystic odontogenic tumor: a case report [J]. Inter J Stomatol, 2017, 44(1): 59-62.
[14] Geng Fengxue, Pan Yaping.. Biological functions of microRNA-203 and its role in oral diseases [J]. Inter J Stomatol, 2016, 43(6): 685-689.
[15] Li Long, Huang Hongzhang.. Role of microRNA-205 on chemoresistance and its mechanism in tumor [J]. Inter J Stomatol, 2016, 43(6): 734-738.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[9] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[10] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .