国际口腔医学杂志

国际口腔医学杂志 ›› 2026, Vol. 53 ›› Issue (2): 247-256.doi: 10.7518/gjkq.2026025

• 综述 • 上一篇    

乳酸及乳酸化修饰在口腔鳞状细胞癌中的研究进展

付莹欣1,2(),顾智玉2,周灵2,林龙2,林静2,刘云坤2()   

  1. 1.南京医科大学附属口腔医院 南京 210029
    2.遵义医科大学附属口腔医院 遵义 563000
  • 收稿日期:2025-05-28 修回日期:2025-07-28 出版日期:2026-03-01 发布日期:2026-02-13
  • 通讯作者: 刘云坤
  • 作者简介:付莹欣，住院医师，学士，Email：fuyx0611@163.com
  • 基金资助:
    贵州省卫生健康委科学技术基金(gzwkj2025-457);贵州省教育厅高等学校自然科学研究项目(黔教技[2024]128号)

Progress in research on lactic acid and lactylation modification in oral squamous cell carcinoma

Yingxin Fu1,2(),Zhiyu Gu2,Ling Zhou2,Long Lin2,Jing Lin2,Yunkun Liu2()   

  1. 1.The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China
    2.Stomatology Hospital Affiliated to Zunyi Medical University, Zunyi 563000, China
  • Received:2025-05-28 Revised:2025-07-28 Online:2026-03-01 Published:2026-02-13
  • Contact: Yunkun Liu
  • Supported by:
    Science and Technology Foundation of Guizhou Provincial Health Commission(gzwkj2025-457);Natural Science Research Project of Higher Education Institutions, Guizhou Provincial Department of Education([2024]128)

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摘要：

乳酸作为葡萄糖无氧氧化产物，长期以来被认为是代谢废物。随着研究的深入，乳酸在细胞信号传导、代谢调节、免疫调节、能量代谢等方面发挥着重要作用。蛋白质乳酸化修饰是由乳酸介导的一种新型翻译后修饰，可直接改变蛋白质的化学结构与功能，刺激基因转录，改变细胞表型，参与多种疾病的发生发展。口腔鳞状细胞癌（OSCC）是头颈部最常见的恶性肿瘤之一，通过糖酵解途径产生大量乳酸，为肿瘤细胞提供能量和生物合成前体；乳酸通过介导表观遗传调控机制，影响肿瘤的发生进展。本文综述乳酸及蛋白质乳酸化修饰在OSCC发生发展过程中的研究进展，总结出靶向乳酸代谢及其修饰过程可作为OSCC潜在治疗策略，为代谢干预联合表观遗传治疗提供了新视角和理论依据。

关键词: 乳酸, 乳酸化修饰, 口腔鳞状细胞癌, 糖酵解, 乳酸脱氢酶, 表观遗传调控

Abstract:

Lactic acid, a product of anaerobic glycolysis, has long been considered a metabolic waste product. How-ever, recent advancements in lactic acid research have established its crucial roles in signal transduction, metabolic regulation, immune modulation, and energy metabolism. Protein lactylation, a novel post-translational modification mediated by lactic acid, can directly modify protein chemical structure and function, enhance gene transcription, mo-dulate cell phenotypes, and contribute to the pathogenesis of various diseases. Oral squamous cell carcinoma, a highly prevalent malignant tumor in the head and neck region, generates substantial amounts of lactic acid via the glycolytic pathway to fuel tumor cells and supply biosynthetic precursors. Furthermore, lactic acid affects tumorigenesis and progression by mediating epigenetic regulatory mechanisms. This review summarizes recent research progress on the roles of lactic acid and protein lactylation in the development and progression of oral squamous cell carcinoma. It not only reveals how lactate and lactylation influence tumorigenesis but also highlights that targeting lactate metabolism and its modification processes may serve as a potential therapeutic strategy for oral squamous cell carcinoma. Thus, this work offers a novel perspective and theoretical basis for metabolic interventions combined with epigenetic therapy.

Key words: lactic acid, lactylation modification, oral squamous cell carcinoma, glycolysis, lactate dehydrogenase, epigenetic regulation

中图分类号: 

  • R739.81
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