国际口腔医学杂志

国际口腔医学杂志 ›› 2025, Vol. 52 ›› Issue (5): 662-669.doi: 10.7518/gjkq.2025085

• 综述 • 上一篇    下一篇

正畸诱导性牙根吸收防治策略的研究进展

刘艺(),郑博文,刘奕()   

  1. 中国医科大学口腔医学院·附属口腔医院正畸教研室沈阳市口腔正畸疾病临床医学研究中心 沈阳 110002
  • 收稿日期:2024-08-02 修回日期:2024-12-02 出版日期:2025-09-01 发布日期:2025-08-27
  • 通讯作者: 刘奕
  • 作者简介:刘艺，博士，Email：yliu@cmu.edu.cn
  • 基金资助:
    辽宁省教育厅高校基本科研项目(LJKMZ20221190)

Advancements in prevention and treatment strategies for orthodontically induced root resorption

Yi Liu(),Bowen Zheng,Yi Liu()   

  1. Dept. of Orthodontics, School and Hospital of Stomatology, China Medical University, Shenyang Clinical Medical Research Center of Orthodontic Disease, Shenyang 110002, China
  • Received:2024-08-02 Revised:2024-12-02 Online:2025-09-01 Published:2025-08-27
  • Contact: Yi Liu
  • Supported by:
    Basic Scientific Research Project of Education Department of Liaoning Province(LJKMZ20221190)

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摘要：

正畸诱导性牙根吸收（OIRR）是临床正畸治疗中最为常见的医源性不良反应之一，危害牙齿寿命，影响矫治效果。近年来，学者们通过体内外研究，通过物理方法、激素、药物、纳米靶向补充物及干细胞相关产物等多种方式，从促进牙骨质代谢、改变机械压力下牙骨质微环境等方面提出了新颖的OIRR应对方法，以期促进牙根修复，提高牙骨质矿化，缓解牙周损伤。其中，干细胞及相关产物或许成为揭示牙根吸收相关修复机制的新靶点。本文针对OIRR防治策略的最新进展作一总结，以期为临床治疗提供参考。

关键词: 正畸, 正畸诱导性牙根吸收, 牙骨质, 干细胞疗法

Abstract:

Orthodontically induced inflammatory root resorption (OIRR) is one of the most common iatrogenic complications associated with clinical orthodontic treatment, potentially compromising therapeutic outcomes and threatening tooth life. In recent years, various novel strategies have been proposed to mitigate OIRR by enhancing root repair, promo-ting cementum mineralization and minimizing periodontal damage. These emerging approaches aim to modulate cementum metabolism and the microenvironment under mechanical stress through in vitro and in vivo studies. Strategies include the application of physical therapies, hormones, pharmacological agents, nanotechnology-based targeting systems, and stem cell-derived products. Stem cells and their secreted byproducts have shown promise as therapeutic candidates for facilitating cementum regeneration and revealing underlying mechanisms of root resorption repair. This review summarizes recent advancements in the prevention and treatment of OIRR, providing a comprehensive reference for clinical applications and future research directions.

Key words: orthodontics, orthodontically induced inflammatory root resorption, cementum, stem cell therapy

中图分类号: 

  • R783.5

图 1

OIRR发生及修复相关因子/通路简图"

图2

OIRR防治策略机制简图"

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