国际口腔医学杂志

国际口腔医学杂志 ›› 2024, Vol. 51 ›› Issue (6): 699-705.doi: 10.7518/gjkq.2024101

• 口腔正畸专栏 • 上一篇    

正畸复发研究领域中4种有前景的生物药物的研究进展

刘曼1(),孟耀2(),牛茂1   

  1. 1.深圳职业技术大学医学技术与护理学院 深圳 518048
    2.深圳市儿童医院口腔正畸科 深圳 518000
  • 收稿日期:2024-04-15 修回日期:2024-09-18 出版日期:2024-11-01 发布日期:2024-11-04
  • 通讯作者: 孟耀
  • 作者简介:刘曼，副教授，硕士，Email：liumandentist@126.com
  • 基金资助:
    广东省教育厅普通高校特色创新类项目(2019GKTSCX-091);深圳市科技创新委员会自由探索项目(JCYJ2018022816495-7104);深圳市科技创新委员会高校稳定支持项目(［2021］0877)

Progress of the research on four promising biopharmaceuticals for intervening in orthodontic recurrence

Man Liu1(),Yao Meng2(),Mao Niu1   

  1. 1.School of Medical Technology and Nursing, Shenzhen Polytechnic University, Shenzhen 518048, China
    2.Dept. of Orthodontics, Shenzhen Children’s Hospital, Shenzhen 518000, China
  • Received:2024-04-15 Revised:2024-09-18 Online:2024-11-01 Published:2024-11-04
  • Contact: Yao Meng
  • Supported by:
    Guangdong Provincial Department of Education’s Characteristic Innovation Project for Ordinary Universities(2019GKTSCX091);Free Exploration Project of Shenzhen Science and Technology Innovation Committee(JCYJ20180228164957104);Shenzhen Science and Technology Innovation Committee University Stability Support Pro-ject([2021]0877)

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摘要：

正畸术后复发是口腔正畸学研究热点之一。目前观点认为由于正畸牙移动和正畸牙复发期间发生的生理模式具有相似性，所以通过靶向参与牙槽骨改建的降低正畸牙移动速率的生物化学制剂可以潜在地调节正畸牙复发。通过局部给药和全身给药干预正畸复发的相关研究药物目前主要处于体外实验研究阶段。在动物实验中观察到一些生物药物具有其无创、不良反应小、干预方便等特点，成为近年来应用于干预正畸复发相关研究的重要方向。本文针对补骨脂、植物雌激素依普黄酮、乳铁蛋白、雌激素受体调节剂雷洛昔芬这4类生物药物的相关成骨机制及其在正畸术后复发领域的基础研究进行综述。

关键词: 正畸牙移动, 复发, 生物医学药物, 中成药

Abstract:

Orthodontic relapse remains a prominent focus in orthodontic research owing to its clinical importance. Current insights suggest that the physiological similarity between orthodontic tooth movement and subsequent relapse warrants the exploration of biochemical agents targeting alveolar bone remodeling processes. Such agents, which can modulate the rate of orthodontic tooth movement, hold promise for regulating orthodontic relapse. The investigation of interventions for orthodontic relapse, primarily through local and systemic drug administration, is predominantly in the in vitro experimental stage. Notably, in animal studies, certain biopharmaceuticals have emerged as pivotal avenues of research due to their noninvasive nature, minimal side effects, and facile administration. This review synthesizes the osteogenic mechanisms and foundational research concerning four classes of biological drugs implicated in postorthodontic relapse: psoralen, phytoestrogenic isoflavone, lactoferrin, and the estrogen receptor modulator raloxifene.

Key words: orthodontic tooth movement, relapse, biomedical drugs, traditional Chinese medicine

中图分类号: 

  • R783.5

图 1

补骨脂、依普黄酮、乳铁蛋白和雷洛昔芬在调节骨稳态促进骨形成方面的研究机制Wnt分泌型糖蛋白/β连环蛋白（wingless/integrated β-catenin，Wnt/β-catenin），雌激素受体（estrogen receptor，ER），芳香烃受体/雌激素受体α（aryl hydrocarbon receptor/estrogen receptor alpha，AhR/ERα），磷脂酰肌醇3激酶（phosphatidylinositol 3-kinase，PI3K），丝裂原活化蛋白激酶（mitogen-activated protein kinase，MAPK），蛋白激酶B/激活蛋白-1（protein kinase B/activator protein-1，AKT/AP-1），骨形态发生蛋白2（bone morphogenetic protein-2，BMP-2），磷脂酰肌醇3-激酶/蛋白激酶B（phosphatidylinositol 3-kinase/protein kinase B，PI3K/AKT），核苷酸结合寡聚化结构域、含Leucine-Rich重复蛋白3（nucleotide-binding oligomerization domain， leucine-rich repeat and pyrin domain-containing 3，NLRP3），肿瘤坏死因子-α（tumor necrosis factor-alpha，TNF-α），转化生长因子β（transforming growth factor-β，TGF-β）。"

1 Rosyida NF, Ana ID, Ali Alhasyimi A. The use of polymers to enhance post-orthodontic tooth stability[J]. Polymers, 2022, 15(1): 103.
2 Alassiry AM. Orthodontic retainers: a contemporary overview[J]. J Contemp Dent Pract, 2019, 20(7): 857-862.
3 Shah SS, Nankar MY, Bendgude VD, et al. Orofacial myofunctional therapy in tongue thrust habit: a narrative review[J]. Int J Clin Pediatr Dent, 2021, 14(2): 298-303.
4 孟耀, 刘曼, 邓倩楠. 正畸应力作用下牙龈肌成纤维细胞表达的初步研究[J]. 华西口腔医学杂志, 2019, 37(5): 537-540.
Meng Y, Liu M, Deng QN. Expression of myofibroblast in gingival after orthodontic loading[J]. West China J Stomatol, 2019, 37(5): 537-540.
5 Millett D. The rationale for orthodontic retention: piecing together the jigsaw[J]. Br Dent J, 2021, 230(11): 739-749.
6 Franzen TJ, Monjo M, Rubert M, et al. Expression of bone markers and micro-CT analysis of alveolar bone during orthodontic relapse[J]. Orthod Craniofac Res, 2014, 17(4): 249-258.
7 Kaklamanos EG, Makrygiannakis MA, Athanasiou AE. Could medications and biologic factors affect post-orthodontic tooth movement changes? A systematic review of animal studies[J]. Orthod Craniofac Res, 2021, 24(1): 39-51.
8 Chauhan N, Kumar M, Chaurasia S, et al. A comprehensive review on drug therapies and nanomaterials used in orthodontic treatment[J]. Curr Pharm Des, 2023, 29(39): 3154-3165.
9 鲁亚奇, 张晓, 王金金, 等. 补骨脂化学成分及药理作用研究进展[J]. 中国实验方剂学杂志, 2019, 25(3): 180-189.
Lu YQ, Zhang X, Wang JJ, et al. Research progress on chemical constituents and pharmacological actions of psoralea fructus[J]. Chin J Exp Tradit Med Formulae, 2019, 25(3): 180-189.
10 Zhang R, Shi WM, Li LF, et al. Biological activity and health promoting effects of psoralidin[J]. Phar-mazie, 2019, 74(2): 67-72.
11 Sharifi-Rad J, Kamiloglu S, Yeskaliyeva B, et al. Pharmacological activities of psoralidin: a comprehensive review of the molecular mechanisms of action[J]. Front Pharmacol, 2020, 11: 571459.
12 Yang JL, Wen LR, Jiang YM, et al. Natural estrogen receptor modulators and their heterologous biosynthesis[J]. Trends Endocrinol Metab, 2019, 30(1): 66-76.
13 Chen LL, Chen SG, Sun P, et al. Psoralea corylifolia L: a comprehensive review of its botany, traditional uses, phytochemistry, pharmacology, toxicology, quality control and pharmacokinetics[J]. Chin Med, 2023, 18(1): 4.
14 王剑, 李想, 张宇, 等. 异补骨脂素促进大鼠骨髓间充质干细胞向骨细胞成分化并抑制其向脂肪细胞分化[J]. 内蒙古医学杂志, 2021, 53(3): 265-266, 271.
Wang J, Li X, Zhang Y, et al. Isopsoralen promotes the differentiation of rat bone marrow mesenchymal stem cells into osteoblasts and inhibits their differentiation into osteoblasts[J]. Inn Mong Med J, 2021, 53(3): 265-266, 271.
15 Ge LN, Cui YZ, Cheng K, et al. Isopsoralen enhanced osteogenesis by targeting AhR/ERα[J]. Mole-cules, 2018, 23(10): 2600.
16 刘小灿, 王旭霞, 吴晓晓, 等. 补骨脂对大鼠正畸后稳定性的影响[J]. 上海口腔医学, 2019, 28(5): 455-459.
Liu XC, Wang XX, Wu XX, et al. Effect of psoralen on the stability after orthodontic tooth movement in rats[J]. Shanghai J Stomatol, 2019, 28(5): 455-459.
17 吴晓晓. 补骨脂素对大鼠正畸牙移动后复发的影响[D]. 济南: 山东大学, 2017.
Wu XX. Effect of psoralen on the recurrence of ortho-dontic tooth movement in rats[D]. Jinan: Shandong University, 2017.
18 王军, 王剑, 鲁敏, 等. 异补骨脂素通过PPAR-γ-Axin2-Wnt信号通路调节对大鼠骨代谢的影响[J]. 世界中医药, 2021, 16(9): 1413-1416.
Wang J, Wang J, Lu M, et al. Effects of isopsoralen on bone metabolism in rats via PPAR gamma-Axin 2-Wnt signal regulation[J]. World Chin Med, 2021, 16(9): 1413-1416.
19 高子茏, 李婷, 吕政, 等. 补骨脂素联合转化生长因子β1诱导骨髓间充质干细胞向软骨细胞的分化[J]. 中国组织工程研究, 2022, 26(30): 4884-4888.
Gao ZL, Li T, Lü Z, et al. Psoralen combined with transforming growth factor beta 1 induces the differentiation of bone marrow mesenchymal stem cells into chondrocytes[J]. Chin J Tissue Eng Res, 2022, 26(30): 4884-4888.
20 Chai LJ, Zhou K, Wang SX, et al. Psoralen and bakuchiol ameliorate M-CSF plus RANKL-induced osteoclast differentiation and bone resorption via inhibition of AKT and AP-1 pathways in vitro [J]. Cell Physiol Biochem, 2018, 48(5): 2123-2133.
21 Patra S, Gorai S, Pal S, et al. A review on phytoestrogens: current status and future direction[J]. Phytother Res, 2023, 37(7): 3097-3120.
22 代书林, 王旭霞, 乜福娇, 等. 异普黄酮对大鼠正畸牙复发过程中牙周组织改建的影响[J]. 上海口腔医学, 2021, 30(1): 23-27.
Dai SL, Wang XX, Nie FJ, et al. Effect of ipriflavone on reconstruction of periodontal tissues during recurrence of orthodontic teeth in rats[J]. Shanghai J Stomatol, 2021, 30(1): 23-27.
23 Gao AG, Zhou YC, Hu ZJ, et al. Ipriflavone promotes osteogenesis of MSCs derived from osteoporotic rats[J]. Eur Rev Med Pharmacol Sci, 2018, 22(14): 4669-4676.
24 Han YY, Wang XX, Ma D, et al. Ipriflavone promotes proliferation and osteogenic differentiation of periodontal ligament cells by activating GPR30/PI3K/AKT signaling pathway[J]. Drug Des Devel Ther, 2018, 12: 137-148.
25 Di Naro E, Loverro M, Converti I, et al. The effect of menopause hypoestrogenism on osteogenic differentiation of periodontal ligament cells (PDLC) and stem cells (PDLCs): a systematic review[J]. Healthcare, 2021, 9(5): 572.
26 Ming LG, Chen KM, Xian CJ. Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling[J]. J Cell Physiol, 2013, 228(3): 513-521.
27 Casarrubios L, Gómez-Cerezo N, Feito MJ, et al. Ipriflavone-loaded mesoporous nanospheres with potential applications for periodontal treatment[J]. Nanomaterials (Basel), 2020, 10(12): 2573.
28 Chen Y, Li J, Shi J, et al. Ipriflavone suppresses NLRP3 inflammasome activation in host response to biomaterials and promotes early bone healing[J]. J Clin Periodontol, 2022, 49(8): 814-827.
29 Superti F. Lactoferrin from bovine milk: a protective companion for life[J]. Nutrients, 2020, 12(9): 2562.
30 纪颖, 艾连中, 邢明霞, 等. 基于牛乳铁蛋白的生产技术创新及应用研究进展[J]. 食品与发酵工业, 2022, 48(15): 332-340.
Ji Y, Ai LZ, Xing MX, et al. Advances on bovine lactoferrin-based technical innovation and application[J]. Food Ferment Ind, 2022, 48(15): 332-340.
31 Hao LY, Shan Q, Wei JY, et al. Lactoferrin: major physiological functions and applications[J]. Curr Pro-tein Pept Sci, 2019, 20(2): 139-144.
32 Wang B, Timilsena YP, Blanch E, et al. Lactoferrin: structure, function, denaturation and digestion[J]. Crit Rev Food Sci Nutr, 2019, 59(4): 580-596.
33 Zhang JL, Han X, Shan YJ, et al. Effect of bovine lactoferrin and human lactoferrin on the proliferative activity of the osteoblast cell line MC3T3-E1 in vitro [J]. J Dairy Sci, 2018, 101(3): 1827-1833.
34 Liu M, Fan FJ, Shi PJ, et al. Lactoferrin promotes MC3T3-E1 osteoblast cells proliferation via MAPK signaling pathways[J]. Int J Biol Macromol, 2018, 107(Pt A): 137-143.
35 Icriverzi M, Dinca V, Moisei M, et al. Lactoferrin in bone tissue regeneration[J]. Curr Med Chem, 2020, 27(6): 838-853.
36 Li QL, Zhao J, Hu WP, et al. Effects of recombinant human lactoferrin on osteoblast growth and bone status in piglets[J]. Anim Biotechnol, 2018, 29(2): 90-99.
37 Xu Y, Zhao TY, Ren HW, et al. Urinary metabolic profiling via LC-MS/MS reveals impact of bovine lactoferrin on bone formation in growing SD rats[J]. Nutrients, 2020, 12(4): 1116.
38 张宏宏, 卢海丽, 陈媛, 等. 乳铁蛋白对正畸复发移动过程中牙周改建的影响[J]. 广西医科大学学报, 2021, 38(1): 23-27.
Zhang HH, Lu HL, Chen Y, et al. Effect of lactoferrin on the periodontal remodeling during orthodontic recurrence and movement[J]. J Guangxi Med Univ, 2021, 38(1): 23-27.
39 Mondockova V, Adamkovicova M, Lukacova M, et al. The estrogen receptor 1 gene affects bone mineral density and osteoporosis treatment efficiency in Slovak postmenopausal women[J]. BMC Med Genet, 2018, 19(1): 174.
40 Koth VS, Salum FG, de Figueiredo MAZ, et al. Morphological and immunohistochemical features of tooth extraction sites in rats treated with alendronate, raloxifene, or strontium ranelate[J]. Clin Oral Investig, 2021, 25(5): 2705-2716.
41 Rolland A, Sorel O, Gebeile-Chauty S. Development of professional recommendations on orthodontic retention: short version[J]. Orthod Fr, 2023, 94(1): 55-68.
42 Ansari MD, Shafi S, Pandit J, et al. Raloxifene encapsulated spanlastic nanogel for the prevention of bone fracture risk via transdermal administration: pharmacokinetic and efficacy study in animal model[J]. Drug Deliv Transl Res, 2024, 14(6): 1635-1647.
43 Khamees AM, Al Groosh DH. Effect of vitamin D deficiency on postorthodontic relapse: an animal study[J]. Clin Exp Dent Res, 2023, 9(4): 701-710.
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