儿童复发性阿弗他溃疡病因学的研究进展

doi:10.7518/gjkq.2018.02.005

国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (2): 145-149.doi: 10.7518/gjkq.2018.02.005

儿童复发性阿弗他溃疡病因学的研究进展

蔡东霖¹, 卢锐^1,2

1.口腔基础医学省部共建国家重点实验室培育基地和口腔生物医学教育部重点实验室,武汉大学口腔医学院武汉 430079
2.武汉大学口腔医院口腔黏膜科武汉 430079

收稿日期:2017-09-21 修回日期:2017-11-02 出版日期:2018-03-01 发布日期:2018-03-01
通讯作者: 卢锐,副主任医师,博士,Email：lurui@whu.edu.cn
作者简介:蔡东霖,硕士,Email：2012302220028@whu.edu.cn
基金资助:
武汉中青年医学骨干人才培养工程（2017年第五批）

Research progress on the etiology of recurrent aphthous ulcer in children

Cai Donglin¹, Lu Rui^1,2

1.The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) &Key Laboratory of Oral Biomedicine Ministry of Education, School of Stomatology, Wuhan University, Wuhan 430079, China;
2.Dept. of Oral Medicine, Hospital of Stomatology, Wuhan University, Wuhan 430079, China

Received:2017-09-21 Revised:2017-11-02 Online:2018-03-01 Published:2018-03-01
Supported by:
This study was supported by the Cultivation Project of Wuhan Young and Middle-aged Backbone Talent in Medicine (the fifth batch of 2017).

摘要/Abstract

摘要： 复发性阿弗他溃疡（RAU）是最常见的口腔黏膜溃疡类疾病,虽然在各个年龄段均可发病,但其首发多见于儿童期。RAU儿童作为该病患者中的特殊群体,在病因学上具有一定的特殊性。目前已知的与儿童RAU有关的病因包括遗传因素、局部创伤、心理因素、营养缺乏、微生物感染、免疫反应异常等,此外,一些儿童RAU还与多种全身系统疾病有关,本文针对儿童RAU病因学的研究进展作一综述。

关键词: 复发性阿弗他溃疡, 儿童, 病因

Abstract: Recurrent aphthous ulcer (RAU) is the most common ulcerative disease of the oral mucosa. Although RAU appears in all ages, the onset of RAU peaks during childhood. Childhood RAU, as a special patient group, displays distinct etiology. The etiology of childhood RAU includes genetic, local trauma, psychologic, nutritional factors, microbial infection, and abnormal immunologic response. Moreover, some cases of childhood RAU are associated with several systemic diseases. This article presents the current progress on the etiology of RAU in children.

Key words: recurrent aphthous ulcer, children, etiology

中图分类号:

R781.5

蔡东霖, 卢锐. 儿童复发性阿弗他溃疡病因学的研究进展[J]. 国际口腔医学杂志, 2018, 45(2): 145-149.

Cai Donglin, Lu Rui. Research progress on the etiology of recurrent aphthous ulcer in children[J]. Inter J Stomatol, 2018, 45(2): 145-149.

参考文献

[1] Chavan M, Jain H, Diwan N, et al.Recurrent aphthous stomatitis: a review[J]. J Oral Pathol Med, 2012, 41(8):577-583.
[2] Akintoye SO, Greenberg MS.Recurrent aphthous stomatitis[J]. Dent Clin North Am, 2014, 58(2):281-297.
[3] Lehner T.Autoimmunity in oral diseases, with special reference to recurrent oral ulceration[J]. Proc R Soc Med, 1968, 61(5):515-524.
[4] Sklavounou-Andrikopoulou A, Mitsea AG, Donta-Bakoyianni C.Study of recurrent aphthous ulcers in a Greek population of children and adolescents[J]. Hellenic Dent J, 2001, 11:33-38.
[5] Krisdapong S, Sheiham A, Tsakos G.Impacts of re-current aphthous stomatitis on quality of life of 12- and 15-year-old Thai children[J]. Qual Life Res, 2012, 21(1):71-76.
[6] Slebioda Z, Szponar E, Kowalska A.Etiopathogenesis of recurrent aphthous stomatitis and the role of immu-nologic aspects: literature review[J]. Arch Immunol Ther Exp (Warsz), 2014, 62(3):205-215.
[7] Field EA, Brookes V, Tyldesley WR.Recurrent aph-thous ulceration in children—a review[J]. Int J Pae-diatr Dent, 1992, 2(1):1-10.
[8] Montgomery-Cranny JA, Wallace A, Rogers HJ, et al.Management of recurrent aphthous stomatitis in children[J]. Dent Update, 2015, 42(6):564-566.
[9] Jurge S, Kuffer R, Scully C, et al.Mucosal disease series. Number Ⅵ. Recurrent aphthous stomatitis[J]. Oral Dis, 2006, 12(1):1-21.
[10] 尹文国. 儿童复发性口疮血清微量元素与免疫功能检测结果分析[J]. 中国医药导报, 2012, 9(4):85-86.
Yin WG.Analysis of serum trace elements and immunity test results in the children with recurrent aphtha[J]. Chin Med Her, 2012, 9(4):85-86.
[11] 黄晓佳, 何晓雷, 吴志芳, 等. 复发性口腔溃疡儿童的T细胞亚群及微量元素的研究[J]. 全科医学临床与教育, 2009, 7(4):359-360, 363.
Huang XJ, He XL, Wu ZF, et al.Study of T cells subpopulation and trace elments in children with recurrent oral ulcer[J]. Clin Edu Gen Pract, 2009, 7(4):359-360, 363.
[12] Gürkan A, Özlü SG, Altıaylık-Özer P, et al. Recurrent aphthous stomatitis in childhood and adolescence: a single-center experience[J]. Pediatr Dermatol, 2015, 32(4):476-480.
[13] Fritscher AM, Cherubini K, Chies J, et al.Associa-tion between Helicobacter pylori and recurrent aph-thous stomatitis in children and adolescents[J]. J Oral Pathol Med, 2004, 33(3):129-132.
[14] Oda D.Helicobacter pylori (HP) may be involved in the pathogenesis of recurrent aphthous ulcers in children and adolescents[J]. J Evid Based Dent Pract, 2005, 5(1):45-46.
[15] Baccaglini L.Myths and evidence on the link between recurrent aphthous stomatitis and systemic diseases[J]. Oral Dis, 2012, 18(5):520.
[16] Manthiram K, Li SC, Hausmann JS, et al.Physicians’ perspectives on the diagnosis and management of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome[J]. Rheumatol Int, 2017, 37(6):883-889.
[17] Wekell P, Karlsson A, Berg S, et al.Review of auto-inflammatory diseases, with a special focus on perio-dic fever, aphthous stomatitis, pharyngitis and cervi-cal adenitis syndrome[J]. Acta Paediatr, 2016, 105(10): 1140-1151.
[18] Ali NS, Sartori-Valinotti JC, Bruce AJ.Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome[J]. Clin Dermatol, 2016, 34(4):482-486.
[19] Theodoropoulou K, Vanoni F, Hofer M.Periodic fe-ver, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome: a review of the patho-genesis[J]. Curr Rheumatol Rep, 2016, 18(4):18.
[20] Koné-Paut I.Behçet’s disease in children, an overview[J]. Pediatr Rheumatol Online J, 2016, 14(1):10.
[21] Nanthapisal S, Klein NJ, Ambrose N, et al.Paedia-tric Behçet’s disease: a UK tertiary centre experience[J]. Clin Rheumatol, 2016, 35(10):2509-2516.
[22] Krzywicka B, Herman K, Kowalczyk-Zając M, et al.Celiac disease and its impact on the oral health status-review of the literature[J]. Adv Clin Exp Med, 2014, 23(5):675-681.
[23] Marty M, Bailleul-Forestier I, Vaysse F.Recurrent aphthous stomatitis as a marker of Celiac disease in children[J]. Pediatr Dermatol, 2016, 33(2):241.
[24] Ferraz EG, Campos Ede J, Sarmento VA, et al.The oral manifestations of celiac disease: information for the pediatric dentist[J]. Pediatr Dent, 2012, 34(7): 485-488.
[25] Skrzat A, Olczak-Kowalczyk D, Turska-Szybka A.Crohn’s disease should be considered in children with inflammatory oral lesions[J]. Acta Paediatr, 2017, 106(2):199-203.
[26] Crippa R, Zuccotti GV, Mantegazza C.Oral manifesta-tions of gastrointestinal diseases in children. Part 2: Crohn’s disease[J]. Eur J Paediatr Dent, 2016, 17(2): 164-166.
[27] Chen Y, Fang L, Yang X.Cyclic neutropenia presen-ting as recurrent oral ulcers and periodontitis[J]. J Clin Pediatr Dent, 2013, 37(3):307-308.
[28] Magalhães MG, Bueno DF, Serra E, et al.Oral mani-festations of HIV positive children[J]. J Clin Pediatr Dent, 2001,25(2):103-106.
[29] Jose R, Chandra S, Puttabuddi JH, et al.Prevalence of oral and systemic manifestations in pediatric HIV cohorts with and without drug therapy[J]. Curr HIV Res, 2013, 11(6):498-505.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

儿童复发性阿弗他溃疡病因学的研究进展

Research progress on the etiology of recurrent aphthous ulcer in children

RichHTML

PDF (PC)

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

Metrics

本文评价

推荐阅读 10

[1]	吴礼安. 部分断冠粘接术在儿童恒前牙复杂冠根折中的初步应用[J]. 国际口腔医学杂志, 2023, 50(6): 623-631.
[2]	杨静,柳登高. 内镜下激光碎石术治疗唾液腺结石病的研究进展[J]. 国际口腔医学杂志, 2023, 50(6): 704-710.
[3]	高若凡,夏斌. 基于慢性疾病管理理念的重度低龄儿童龋管理方法[J]. 国际口腔医学杂志, 2023, 50(3): 341-346.
[4]	任海霞,刘颍凤,梁慧敏,李家勇,温春琴,王春梅. 虚拟现实技术在儿童深龋治疗中对牙科畏惧的干预效果研究[J]. 国际口腔医学杂志, 2022, 49(5): 529-536.
[5]	曾杨林,谭学莲,宋东哲,黄定明. 牙根内吸收临床诊治方法的研究进展[J]. 国际口腔医学杂志, 2022, 49(5): 561-568.
[6]	查蕴宸,张佳佳,孔卫东. 原发性牙齿萌出障碍病因的研究进展[J]. 国际口腔医学杂志, 2022, 49(4): 386-391.
[7]	陈思婷,钟雄,孟文霞. Nod样受体家族嘌呤结构域3炎症小体在口腔黏膜病中的研究进展[J]. 国际口腔医学杂志, 2022, 49(4): 471-475.
[8]	贺红. 伴扁桃体肥大Ⅲ类错𬌗畸形儿童早期矫治的临床诊疗策略[J]. 国际口腔医学杂志, 2022, 49(3): 249-254.
[9]	朱锦怡,樊琪,周媛,邹静,黄睿洁. 唾液蛋白作为低龄儿童龋预测标志物的研究进展[J]. 国际口腔医学杂志, 2022, 49(2): 212-219.
[10]	董栩,徐欣. 牙隐裂临床研究进展[J]. 国际口腔医学杂志, 2021, 48(6): 668-674.
[11]	陶慧骞,但红霞. 口腔黏膜瘙痒症的病因与治疗[J]. 国际口腔医学杂志, 2021, 48(1): 119-124.
[12]	赵文俊,郝晓琪,王凯利,刘媛媛,唐蓓,任家银,郑广宁. 对吻磨牙的研究进展[J]. 国际口腔医学杂志, 2021, 48(1): 96-101.
[13]	邓晓宇,张蕴涵,邹静. 低龄儿童龋的早期生物学管理[J]. 国际口腔医学杂志, 2020, 47(5): 581-588.
[14]	邓晓宇,仁青色格,霍媛媛,崔晨,亓文婷,韩轩,黄睿洁,周媛,朱林,邹静,旦增念扎. 西藏自治区城区和牧区儿童患龋情况与相关因素分析[J]. 国际口腔医学杂志, 2020, 47(4): 383-390.
[15]	吴勇志,尧可,陈思宇,黄能文,王了. 多生牙及其诊断治疗[J]. 国际口腔医学杂志, 2020, 47(3): 311-317.