国际口腔医学杂志

国际口腔医学杂志 ›› 2025, Vol. 52 ›› Issue (1): 117-122.doi: 10.7518/gjkq.2025014

• 综述 • 上一篇    

血清淀粉样蛋白A与牙周炎相关性的研究进展

程守正(),李太文,赵蕾()   

  1. 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心四川大学华西口腔医院牙周病科 成都 610041
  • 收稿日期:2024-05-07 修回日期:2024-08-19 出版日期:2025-01-01 发布日期:2025-01-11
  • 通讯作者: 赵蕾
  • 作者简介:程守正，硕士，Email：15138970198@163.com
  • 基金资助:
    国家自然科学基金(81970944)

Research progress on the correlation between serum amyloid A and periodontitis

Shouzheng Cheng(),Taiwen Li,Lei Zhao()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Periodontology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2024-05-07 Revised:2024-08-19 Online:2025-01-01 Published:2025-01-11
  • Contact: Lei Zhao
  • Supported by:
    National Natural Science Foundation of China(81970944)

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摘要：

牙周炎是以牙周组织炎症和牙槽骨吸收为主要特征的慢性感染性疾病。血清淀粉样蛋白A（SAA）是一种急性期反应蛋白，在机体受到感染、创伤、炎症等刺激后，血清SAA水平迅速升高，发挥免疫调节作用。近年来，对SAA的基因调控、蛋白结构及生物学功能的研究逐渐深入，发现SAA通过调节炎症介质的释放和免疫细胞的功能，促进破骨细胞分化及骨吸收，与牙周炎的发生发展密切相关。本文就SAA的分类、结构、功能及其在牙周炎中的作用机制研究进展做一综述，以期为牙周炎发生发展机制研究和牙周炎防治策略提供新线索。

关键词: 牙周炎, 血清淀粉样蛋白A, 辅助性T细胞17, Toll样受体2

Abstract:

Periodontitis is a chronic inflammatory disease characterized by periodontal tissue inflammation and alveolar bone resorption. Serum amyloid A (SAA) is a kind of acute phase reactive protein. The level of SAA increases rapidly after the body is stimulated by infection, trauma, inflammation, and so on. Recent research has analyzed the gene regulation, protein structure, and biological functions of SAA, revealing that SAA promotes osteoclast differentiation and bone resorption by modulating the release of inflammatory mediators and the function of immune cells. These findings suggest that SAA is closely linked to the occurrence and progression of periodontitis. Therefore, reviews on the classification, structure, function, and roles of SAA in the pathogenesis of periodontitis are crucial to provide new clues to the pathogene-sis, prevention, and treatment of periodontitis.

Key words: periodontitis, serum amyloid protein A, T helper cell 17, Toll-like receptor 2

中图分类号: 

  • R781.4
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