国际口腔医学杂志

国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (1): 23-28.doi: 10.7518/gjkq.2021006

• 牙周专栏 • 上一篇    下一篇

牙龈卟啉单胞菌对不同组织来源血管内皮细胞的作用及机制的研究进展

雷双1,庾靖君2,唐晓琳2()   

  1. 1. 中国医科大学口腔医学院·附属口腔医院儿童口腔科 辽宁省口腔疾病重点实验室 沈阳 110001;
    2. 中国医科大学口腔医学院·附属口腔医院牙周病科 辽宁省口腔疾病重点实验室 沈阳 110001;
  • 收稿日期:2020-06-12 修回日期:2020-09-13 出版日期:2021-01-01 发布日期:2021-01-20
  • 通讯作者: 唐晓琳
  • 作者简介:雷双,讲师,硕士,Email: leishuang90@126.com
  • 基金资助:
    国家自然科学基金(81670999)

Research progress on the effects and mechanisms of Porphyromonas gingivalis on vascular endothelial cells from different tissues

Lei Shuang1,Yu Jingjun2,Tang Xiaolin2()   

  1. 1. Dept. of Pediatric Dentistry, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang 110001, China
    2. Dept. of Perio-dontology, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang 110001, China
  • Received:2020-06-12 Revised:2020-09-13 Online:2021-01-01 Published:2021-01-20
  • Contact: Xiaolin Tang
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81670999)

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摘要：

牙龈卟啉单胞菌是重要的牙周可疑致病菌。牙龈卟啉单胞菌可黏附、侵入并损伤血管内皮细胞,并进入远隔组织器官内,以此参与动脉粥样硬化、阿尔兹海默病等全身疾病的发生和发展过程。近年来研究发现牙龈卟啉单胞菌对不同组织来源血管内皮细胞的致病性及其作用机制均有不同。本文就牙龈卟啉单胞菌对不同组织来源血管内皮细胞的作用及机制作一综述,以拓宽牙龈卟啉单胞菌与全身性疾病的研究思路。

关键词: 牙龈卟啉单胞菌, 血管内皮细胞, 肾小球内皮细胞, 血脑屏障

Abstract:

Porphyromonas gingivalis is a key putative pathogen in chronic periodontitis. P. gingivalis can adhere, invade and injure vascular endothelial cells and enter the distant organs and tissues, by which P. gingivalis can participate in the onset and progress of systemic diseases such as atherosclerosis and Alzheimer s disease. However, recent studies have found that P. gingivalis has distinct pathogenicity and mechanism to vascular endothelial cells from different tissues. This paper reviews the research progress on the effects and mechanisms of P. gingivalis on vascular endothelial cells from different tissues and aims to broaden the view on the research of P. gingivalis with systemic diseases.

Key words: Porphyromonas gingivalis, vascular endothelial cell, glomerular endothelial cells, blood-brain barrier

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