国际口腔医学杂志

国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (5): 617-620.doi: 10.7518/gjkq.2019055

• 综述 • 上一篇    

唇腭裂患者的脑部结构与功能研究进展

邓程丹,石冰,李杨()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院唇腭裂外科 成都 610041
  • 收稿日期:2018-10-02 修回日期:2019-04-25 出版日期:2019-09-01 发布日期:2019-09-10
  • 通讯作者: 李杨
  • 作者简介:邓程丹,硕士,Email： 945060568@qq.com
  • 基金资助:
    国家自然科学基金青年基金(30900391)

Research progress on the brain structure and function of patients with cleft lip and palate

Deng Chengdan,Shi Bing,Li Yang()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-10-02 Revised:2019-04-25 Online:2019-09-01 Published:2019-09-10
  • Contact: Yang Li
  • Supported by:
    This study was supported by National Natural Science Foundation of China(30900391)

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摘要：

非综合型唇腭裂是常见多发的先天性疾病之一,在明显的面部畸形以外,有研究表明唇腭裂患者的脑部结构与正常人也有差异。随着检测技术的发展,这些先进的检测技术越来越多地应用于唇腭裂患者脑部的研究。本文对唇腭裂患者的大脑结构与功能的研究进展作一综述,以便于深入理解及研究唇腭裂患者与正常人的大脑结构与功能差异。

关键词: 唇腭裂, 大脑结构, 功能, 磁共振成像

Abstract:

Cleft lip and cleft palate are highly common congenital disabilities. In addition to the obvious facial deformity, the brain of a patient with cleft lip and palate differs from that of a normal person. The development of advanced detection technologies is enabling detailed studies on the brain of patients with cleft lip and palate. This article reviews the progress of research on such patients’ brain to examine and understand their brain structures and functions.

Key words: cleft lip and palate, brain structure, function, magnetic resonance imaging

中图分类号: 

  • R782.2
[1] de Milly MN, Alison M, Arthurs O , et al. Is fetal cerebral MRI worthwhile in antenatally diagnosed isolated cleft lip with or without palate[J]. Prenat Diagn, 2013,33(3):273-278.
[2] Rosen H, Chiou GJ, Stoler JM , et al. Magnetic resonance imaging for detection of brain abnormalities in fetuses with cleft lip and/or cleft palate[J]. Cleft Palate Craniofac J, 2011,48(5):619-622.
[3] 束煌, 杨峰, 丁桂聪 , 等. 唇腭裂患儿高级听觉中枢的MRI形态学研究[J]. 临床口腔医学杂志, 2012,28(7):430-432.
Shu H, Yang F, Ding GC , et al. A MRI study of auditory center of infants with cleft lip and/or palate[J]. J Clin Stomatol, 2012,28(7):430-432.
[4] Yang FF , McPherson B, Shu H, et al. Structural abnormalities of the central auditory pathway in infants with nonsyndromic cleft lip and/or palate[J]. Cleft Palate Craniofac J, 2012,49(2):137-145.
[5] Adamson CL, Anderson VA, Nopoulos P , et al. Regional brain morphometric characteristics of nonsyndromic cleft lip and palate[J]. Dev Neurosci, 2014,36(6):490-498.
[6] Weinberg SM, Andreasen NC, Nopoulos P . Three-dimensional morphometric analysis of brain shape in nonsyndromic orofacial clefting[J]. J Anat, 2009,214(6):926-936.
[7] Weinberg SM, Parsons TE, Fogel MR , et al. Corpus callosum shape is altered in individuals with nonsyndromic cleft lip and palate[J]. Am J Med Genet A, 2013,161A(5):1002-1007.
[8] Chollet MB , DeLeon VB, Conrad AL, et al. Morphometric analysis of brain shape in children with nonsyndromic cleft lip and/or palate[J]. J Child Neurol, 2014,29(12):1616-1625.
[9] Conrad AL, Dailey S, Richman L , et al. Cerebellum structure differences and relationship to speech in boys and girls with nonsyndromic cleft of the lip and/or palate[J]. Cleft Palate Craniofac J, 2010,47(5):469-475.
[10] DeVolder I, Richman L, Conrad AL , et al. Abnormal cerebellar structure is dependent on phenotype of isolated cleft of the lip and/or palate[J]. Cerebellum, 2013,12(2):236-244.
[11] van der Plas E, Caspell CJ, Aerts AM , et al. Height, BMI, and pituitary volume in individuals with and without isolated cleft lip and/or palate[J]. Pediatr Res, 2012,71(5):612-618.
[12] Boes AD, Murko V, Wood JL , et al. Social function in boys with cleft lip and palate: relationship to ventral frontal cortex morphology[J]. Behav Brain Res, 2007,181(2):224-231.
[13] Nopoulos P, Choe I, Berg S , et al. Ventral frontal cortex morphology in adult males with isolated orofacial clefts: relationship to abnormalities in social function[J]. Cleft Palate Craniofac J, 2005,42(2):138-144.
[14] Nopoulos P, Boes AD, Jabines A , et al. Hyperactivity, impulsivity, and inattention in boys with cleft lip and palate: relationship to ventromedial prefrontal cortex morphology[J]. J Neurodev Disord, 2010,2(4):235-242.
[15] Gassling V, Receveur K, Niederberger U , et al. No deficit in neurocortical information processing in patients with cleft lip and palate[J]. Clin Oral Investig, 2016,20(1):23-30.
[16] Becker DB, Coalson RS, Sachanandani NS , et al. Functional neuroanatomy of lexical processing in children with cleft lip and palate[J]. Plast Reconstr Surg, 2008,122(5):1371-1382.
[17] Shinagawa H, Ono T, Honda E , et al. Distinctive cortical articulatory representation in cleft lip and palate: a preliminary functional magnetic resonance imaging study[J]. Cleft Palate Craniofac J, 2006,43(5):620-624.
[18] Zhang W, Li C, Chen L , et al. Increased activation of the hippocampus during a Chinese character subvocalization task in adults with cleft lip and palate palatoplasty and speech therapy[J]. Neuroreport, 2017,28(12):739-744.
[19] Goldsberry G , O’Leary D, Hichwa R, et al. Functional abnormalities in the neural circuitry of reading in men with nonsyndromic clefts of the lip or palate[J]. Cleft Palate Craniofac J, 2006,43(6):683-690.
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