Int J Stomatol

Int J Stomatol ›› 2020, Vol. 47 ›› Issue (6): 652-660.doi: 10.7518/gjkq.2020111

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Advances in mechanisms for osteogenic differentiation of human periodontal ligament cells induced by cyclic tensile stress

Li Jingya1(),Shui Yusen1,Guo Yongwen2()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-03-29 Revised:2020-06-23 Online:2020-11-01 Published:2020-11-06
  • Contact: Yongwen Guo E-mail:BeiBei980524@163.com;orthoguo@126.com
  • Supported by:
    Youth Program of National Natural Science Foundation of China(81600896);Research and Develop Program of West China Hospital of Stomatology, Sichuan University(LCYJ2019-14)

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Abstract:

Orthodontic tooth movement (OTM) is a complex mechanical-biological mechanism, which is biologically based on mechanical-mediated periodontal tissue remodelling. Bone resorption on the pressure side and bone deposition on the tension side of the periodontal ligament could be observed. Human periodontal ligament cells (hPDLCs) were found to support osteogenic differentiation and periodontal tissue regeneration and maintain homeostasis. At present, many studies have used cyclic tension stress (CTS) for mechanical stimulation during orthodontic treatment to understand the osteogenic differentiation of tension-side hPDLCs. In this review, we will probe into how hPDLCs, as mechanosensitive cells, create initial induction to mechanical signals and then convert primary signals into downstream signals via different mechanotransduction signal pathways. After mechanosensitive cells are regulated, gene expression and protein synthesis are performed. Finally, the paradentium implements bone remodelling. Therefore, this review focuses on the molecular signals and pathways involved in this mechanical signal transduction to discuss how hPDLCs biologically respond to CTS stimulation. This review can provide theoretical evidence for shortening orthodontic treatment time and possible insights into the mechanisms of OTM for further studies.

Key words: cyclic tension stress, human periodontal ligament cells, mechanosensing, mechanotransduction, osteogenic differentiation

CLC Number: 

  • R783.5

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