Int J Stomatol ›› 2019, Vol. 46 ›› Issue (6): 663-669.doi: 10.7518/gjkq.2019081

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Research progress on cross-kingdom interactions between Candida albicans and common oral bacteria

Hu Yao,Cheng Lei,Guo Qiang,Ren Biao()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-02-20 Revised:2019-07-06 Online:2019-11-01 Published:2019-11-14
  • Contact: Biao Ren
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81870778)


Candida albicans is one of the most prevalent commensal species of human microbiota, which can be detected in the oral cavity of 30%-50% healthy adults. However, it is also an opportunistic pathogen that can cause severe skin, mucosal or bloodstream infections. The impact of C. albicans typically depends on its interaction with bacteria. For example, together with other bacteria, C. albicans can participate in the development of caries, denture stomatitis and mucosal infections. Therefore, in this review, the interactions between C. albicans and common oral bacteria and the possible mechanisms are summarised, thereby providing novel ideas on the clinical prevention and treatment of common oral diseases.

Key words: Candida albicans, oral diseases, cross-kingdom interaction

CLC Number: 

  • R37

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