国际口腔医学杂志 ›› 2022, Vol. 49 ›› Issue (3): 332-336.doi: 10.7518/gjkq.2022030

• 综述 • 上一篇    下一篇

牙本质发育不良Ⅰ型及其分型治疗

雷彬1(),陈柯2()   

  1. 1.暨南大学口腔医学院 广州 510000
    2.南方医科大学口腔医院海珠广场院区儿童口腔科 广州 510000
  • 收稿日期:2021-07-21 修回日期:2021-11-06 出版日期:2022-05-01 发布日期:2022-05-09
  • 通讯作者: 陈柯
  • 作者简介:雷彬,住院医师,硕士,Email:435186977@qq.com
  • 基金资助:
    南方医科大学口腔医院高层次人才项目(PY2018022)

Classification and treatment of dentin dysplasia type

Lei Bin1(),Chen Ke2()   

  1. 1.School of Stomatology, Jinan University, Guangzhou 510000, China
    2.Dept. of Pediatric Dentistry, Haizhu Square, Stomatological Hospital of Southern Medical University, Guangzhou 510000, China
  • Received:2021-07-21 Revised:2021-11-06 Online:2022-05-01 Published:2022-05-09
  • Contact: Ke Chen
  • Supported by:
    High-level Talents Project of Stomatological Hospital, Southern Medical University(PY2018022)

摘要:

牙本质发育不良Ⅰ型(DD-Ⅰ)是一种罕见的遗传性牙本质形成障碍疾病,乳恒牙均可受累。该病在临床上表现为牙冠外形色泽正常,牙齿松动明显,可伴有自发性牙槽脓肿或囊肿等。影像学检查则可见牙髓腔消失或呈“新月形”牙髓残余,根短钝或无牙根等表现。关于DD-Ⅰ的发病机制已为大多数学者所研究,其临床治疗通常具有挑战性,本文对近年来DD-Ⅰ的临床分型及表现、致病基因、组织学特点、治疗相关研究进行综述,以期为临床诊治该病提供一定的指导。

关键词: 牙本质发育不良Ⅰ型, 分型, 发病机制, 致病基因, 治疗

Abstract:

Dentin dysplasia type Ⅰ (DD-Ⅰ) is a rare genetic disorder of dentine formation that affects all deciduous and permanent teeth. In this disease, the tooth crown’s appearance, color, and lustre are normal; tooth loosening is obvious; and spontaneous tooth alveolar abscess or cyst may be present. Imaging examinations show that the pulp cavity disappeared or the residual pulp has a “crescent shape” and the root is short and blunt or the root is absent. The pathogenesis of DD-Ⅰ has been studied by most scholars, and its clinical treatment is often challenging. In this paper, the clinical classification and manifestations, pathogenic genes, histological characteristics, and treatment of DD-Ⅰ in recent years are reviewed to provide guidance for the clinical diagnosis and treatment of this disease.

Key words: dentine dysplasia type Ⅰ, classification, pathogenesis, pathogenic gene, treatment

中图分类号: 

  • R 781.2

图 1

DD-Ⅰ亚分类Ⅰa型:髓腔完全闭塞,无牙根形成;Ⅰb型:单条水平新月形牙髓残留,牙根极短,无根管影像;Ⅰc型:2条水平新月形的牙髓残留,牙根发育不完整,无根管影像;Ⅰd型:髓腔及根管冠部可见椭圆形的牙髓结石,牙根长度正常。"

表 1

遗传性牙本质疾病的致病基因"

疾病类型基因位置致病基因
DGI-Ⅰ17q21.33COL1A1
7q21.3COL1A2
DGI-Ⅱ4q22.1DSPP
DGI-Ⅲ4q22.1DSPP
DD-Ⅰ6q27SMOC2
18q21.33VPS4B
3p26.1SSUH2
DD-Ⅱ4q22.1DSPP
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