国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (3): 336-339.doi: 10.7518/gjkq.2017.03.017

• 综述 • 上一篇    下一篇

外泌体与口腔疾病关系的研究进展

吴佳梦, 王效英   

  1. 山东大学口腔医院牙体牙髓病科 山东省口腔组织再生重点实验室 济南 250012
  • 收稿日期:2016-10-12 修回日期:2017-01-11 出版日期:2017-05-01 发布日期:2017-05-01
  • 通讯作者: 王效英,副教授,博士,Email:xiaoyingwang@sdu.edu.cn
  • 作者简介:吴佳梦,硕士,Email:wjm199092@hotmail.com

Research progress on exosomes and oral diseases

Wu Jiameng, Wang Xiaoying.   

  1. Dept. of Conservative Dentistry and Endodontics, Hospital of Stomatology, Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Rege-neration, Jinan 250012, China
  • Received:2016-10-12 Revised:2017-01-11 Online:2017-05-01 Published:2017-05-01

摘要: 外泌体是由各种类型的细胞分泌的多形性囊泡样小体,其中含有蛋白质和RNA等多种成分,具有抗肿瘤免疫、促血管新生等生理功能,并且与口腔疾病密切相关。外泌体可作为口腔癌、口腔黏膜病、唾液腺疾病等口腔疾病诊断的生物标志物,还有作为口腔癌候选抗癌疫苗的可能。本文主要就外泌体及其与口腔疾病的关系作一综述。

关键词: 外泌体, 口腔疾病, 生物标志物

Abstract: Exosomes secreted by various types of cells are small vesicular bodies that contain many types of proteins and RNAs. They have multiple functions, such as anti-tumor immunity and angiogenesis. Their possible use as oral disease biomarkers and vaccine candidates was also discussed. This review presents recent advances in exosomes and the relationship with oral diseases.

Key words: exosome, oral disease, biomarker

中图分类号: 

  • R781
[1] Poliakov A, Spilman M, Dokland T, et al. Structural heterogeneity and protein composition of exosome-like vesicles(prostasomes) in human semen[J]. Pro-state, 2009, 69(2):159-167.
[2] Simons M, Raposo G. Exosomes—vesicular carriers for intercellular communication[J]. Curr Opin Cell Biol, 2009, 21(4):575-581.
[3] Segura E, Amigorena S, Théry C. Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses[J]. Blood Cells Mol Dis, 2005, 35(2):89-93.
[4] Théry C, Amigorena S, Raposo G, et al. Isolation and characterization of exosomes from cell culture supernatants and biological fluids[J]. Curr Protoc Cell Biol, 2006, doi:10.1002/0471143030.cb032-2s30.
[5] de Gassart A, Geminard C, Fevrier B, et al. Lipid raft-associated protein sorting in exosomes[J]. Blood, 2003, 102(13):4336-4344.
[6] Valadi H, Ekström K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells[J]. Nat Cell Biol, 2007, 9(6):654-659.
[7] Keller S, Ridinger J, Rupp AK, et al. Body fluid derived exosomes as a novel template for clinical diagnostics[J]. J Transl Med, 2011, 9:86.
[8] Tan CY, Lai RC, Wong W, et al. Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models[J]. Stem Cell Res Ther, 2014, 5(3):76.
[9] Fujita Y, Kuwano K, Ochiya T, et al. The impact of extracellular vesicle-encapsulated circulating micro-RNAs in lung cancer research[J]. Biomed Res Int, 2014, 2014:486413.
[10] 张志愿, 俞光岩. 口腔颌面外科学[M]. 7版. 北京:人民卫生出版社, 2012:324-342.
Zhang ZY, Yu GY. Oral and maxillofacial surgery [M]. 7th ed. Beijing: People’s Medical Publishing House, 2012:324-342.
[11] Zitvogel L, Regnault A, Lozier A, et al. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes[J]. Nat Med, 1998, 4(5):594-600.
[12] Zlotogorski-Hurvitz A, Dayan D, Chaushu G, et al. Morphological and molecular features of oral fluid-derived exosomes: oral cancer patients versus heal-thy individuals[J]. J Cancer Res Clin Oncol, 2016, 142(1):101-110.
[13] 廖贵清, 李金, 冯炼强, 等. Tca8113细胞exosomes的制备、鉴定及体外抗瘤作用观察[J]. 口腔颌面外科杂志, 2009, 19(6):390-394.
Liao GQ, Li J, Feng LQ, et al. Studies on the isola-tion, identification and anti-tumor mechanism of exosomes from cell line Tca8113[J]. J Oral Maxil-lofac Surg, 2009, 19(6):390-394.
[14] Lamparski HG, Metha-Damani A, Yao JY, et al. Production and characterization of clinical grade exosomes derived from dendritic cells[J]. J Immunol Methods, 2002, 270(2):211-226.
[15] Théry C, Boussac M, Véron P, et al. Proteomic an-alysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles[J]. J Immunol, 2001, 166(12):7309-7318.
[16] 陈谦明, 周曾同. 口腔黏膜病学[M]. 3版. 北京: 北京大学医学出版社, 2008:205-211.
Cheng QM, Zhou ZT. Oral mucosal disease[M]. 3rd ed. Beijing: Peking University Medical Press, 2008: 205-211.
[17] Byun JS, Hong SH, Choi JK, et al. Diagnostic pro-filing of salivary exosomal microRNAs in oral lichen planus patients[J]. Oral Dis, 2015, 21(8):987-993.
[18] Jia HL, He CH, Wang ZY, et al. MicroRNA expre-ssion profile in exosome discriminates extremely severe infections from mild infections for hand, foot and mouth disease[J]. BMC Infect Dis, 2014, 14: 506.
[19] Michael A, Bajracharya SD, Yuen PS, et al. Exo-somes from human saliva as a source of microRNA biomarkers[J]. Oral Dis, 2010, 16(1):34-38.
[20] Hiyoshi Y, Kamohara H, Karashima R, et al. Micro-RNA-21 regulates the proliferation and invasion in esophageal squamous cell carcinoma[J]. Clin Cancer Res, 2009, 15(6):1915-1922.
[21] 王嘉德, 高学军. 牙体牙髓病学[M]. 北京: 北京大学医学出版社, 2006:219-221.
Wang JD, Gao XJ. Endodontics[M]. Beijing: Peking University Medical Press, 2006:219-221.
[22] the presence of external root resorption[J]. Am J Orthod Dentofacial Orthop, 2014, 145(6):787-798.
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