国际口腔医学杂志

国际口腔医学杂志 ›› 2023, Vol. 50 ›› Issue (1): 37-42.doi: 10.7518/gjkq.2023009

• 牙周专栏 • 上一篇    下一篇

Gli1阳性间充质干细胞在牙及牙周组织中的分布及作用

李佩桐(),时彬冕,许春梅,谢旭东,王骏()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医院牙周病科 成都 610041
  • 收稿日期:2022-03-24 修回日期:2022-07-13 出版日期:2023-01-01 发布日期:2023-01-09
  • 通讯作者: 王骏
  • 作者简介:李佩桐，学士，Email：lptn@qq.com
  • 基金资助:
    国家自然科学基金面上项目(82071127);四川省重点研发计划(23ZDYF1722);四川大学华西口腔医院人才队伍建设科研经费资助项目(RCDWJS2020-12)

Distribution and role of Gli1+ mesenchymal stem cells in teeth and periodontal tissues

Li Peitong(),Shi Binmian,Xu Chunmei,Xie Xudong,Wang Jun.()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2022-03-24 Revised:2022-07-13 Online:2023-01-01 Published:2023-01-09
  • Contact: Jun. Wang
  • Supported by:
    National Natural Science Foundation of China General Project(82071127);Si-chuan Key Research and Development Program(23ZDYF1722);Research Funding Support Project for Talent Team Construction of West China Hospital of Stomatology, Sichuan University(RCDWJS2020-12)

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摘要：

Hedgehog（Hh）信号通路在哺乳动物的组织发育和器官形成中发挥重要作用。Gli1是Hh信号通路中重要的转录因子之一，并已被证实为间充质干细胞（MSCs）可靠的体内标记物。Gli1阳性MSCs具有自我更新能力和多向分化潜能，在牙及牙周组织中可分化为多种功能细胞，包括成牙本质细胞、成牙骨质细胞、成纤维细胞和成骨细胞，参与组织的生长发育与稳态维持。本文对目前关于Gli1阳性MSCs在牙及牙周组织的分布与作用的研究进展作一综述，以期为牙及牙周组织的再生治疗提供新思路。

关键词: Gli1, 间充质干细胞, 生长发育, 稳态, 谱系示踪

Abstract:

The Hedgehog (Hh) signaling pathway plays a crucial role in tissue development and organogenesis. Gli1 is one of the key transcription factors in the Hh signaling pathway that has been identified to be a reliable marker for mesenchymal stem cells (MSCs) in vivo. Gli1+ MSCs possess self-renewal ability and multidirectional differentiation potential. In teeth and periodontal tissues, Gli1+ MSCs can differentiate into a variety of cells, including odontoblasts, cementoblasts, fibroblasts, and osteoblasts, that contribute to tissue growth and homeostasis. In this review, we aim to summarize the current progress in the research on the distribution and function of Gli1+ MSCs in teeth and periodontal tissues and provide new insights into regenerative therapy for teeth and periodontal tissues.

Key words: Gli1, mesenchymal stem cells, growth and development, homeostasis, lineage tracing

中图分类号: 

  • R 781

图1

Gli1+MSCs在牙及牙周组织的分布与分化"

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