国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (5): 616-620.doi: 10.7518/gjkq.2020052

• 综述 • 上一篇    

尼古丁对牙槽骨破骨细胞的作用及其机制的研究进展

杨佩佩(),杨羽晨,张强()   

  1. 南昌大学第一附属医院口腔颌面外科 南昌 330006
  • 收稿日期:2019-11-01 修回日期:2020-04-26 出版日期:2020-09-01 发布日期:2020-09-16
  • 通讯作者: 张强
  • 作者简介:杨佩佩,硕士,Email: 978566228@qq.com
  • 基金资助:
    国家自然科学基金(81560189);国家自然科学基金(81260169)

Advances in the mechanism and effect of nicotine on alveolar osteoclasts

Yang Peipei(),Yang Yuchen,Zhang Qiang()   

  1. Dept. of Oral and Maxillofacial Surgery, First Affiliated Hospital of Nanchang University, Nanchang 330006, China
  • Received:2019-11-01 Revised:2020-04-26 Online:2020-09-01 Published:2020-09-16
  • Contact: Qiang Zhang
  • Supported by:
    National Natural Science Foundation of China(81560189);National Natural Science Foundation of China(81260169)

摘要:

吸烟对牙周疾病具有促进作用,而尼古丁作为烟草中有毒化学物质之一,是导致牙周病包括牙龈出血、牙周袋形成、牙槽骨吸收、牙齿松动的重要诱因。牙槽骨的吸收是骨组织的动态平衡被破坏的后果,是指成骨细胞主导的骨形成和破骨细胞主导的骨吸收失去平衡。通过研究尼古丁对破骨细胞及其诱导因子的调控作用,可以阐明尼古丁对于骨代谢的特殊作用,从而进一步论证尼古丁对牙周病发展的诱导作用。本文就尼古丁对破骨细胞的作用及其机制的研究进展进行综述。

关键词: 尼古丁, 破骨细胞, 调控机制

Abstract:

Smoking can promote periodontal disease. As one of the toxic chemicals in tobacco, nicotine is an important cause of periodontal diseases, including gingival bleeding, periodontal pocket formation, alveolar bone absorption and tooth loosening. Alveolar bone resorption results from the disrupted dynamic balance of bone tissue, which refers to the imbalance of bone resorption regulated by osteoblasts and osteoclasts. The special effect of nicotine on bone metabolism was clarified by studying the regulatory effect of nicotine on osteoclasts and inducing factors. The inducing effect of nicotine on the development of periodontal disease was further analysed. This article reviewed the research progress on the effect of nicotine on osteoclasts.

Key words: nicotine, osteoclasts, regulatory mechanism

中图分类号: 

  • R781.4
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