国际口腔医学杂志

国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (2): 131-137.doi: 10.7518/gjkq.2020034

• 牙周专栏 • 上一篇    下一篇

益生菌生态调节在牙周病防治中的应用

刘琳,周婕妤,吴亚菲,赵蕾()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医院牙周病科 成都 610041
  • 收稿日期:2019-07-14 修回日期:2019-12-06 出版日期:2020-03-01 发布日期:2020-03-12
  • 通讯作者: 赵蕾 E-mail:jollyzldoc@163.com
  • 作者简介:刘琳,住院医师,硕士,Email： 1040012620@qq.com
  • 基金资助:
    国家自然科学基金(81371150);国家自然科学基金(81771077);四川省重点研发项目(2018SZ0161)

Application of probiotic ecological regulation in prevention and treatment of periodontal diseases

Liu Lin,Zhou Jieyu,Wu Yafei,Zhao Lei()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-07-14 Revised:2019-12-06 Online:2020-03-01 Published:2020-03-12
  • Contact: Lei Zhao E-mail:jollyzldoc@163.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81371150);This study was supported by National Natural Science Foundation of China(81771077);Key Research and Development Project of Sichuan Province(2018SZ0161)

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摘要：

牙周病的始动因子为菌斑生物膜,近年来菌斑学说越来越倾向于牙周微生态失调。目前牙周病经典的治疗方法为机械性去除菌斑,但疗效存在个体差异性,部分患者需要辅助其他治疗方法。益生菌具有重建宿主微生物群落、调节免疫炎症反应的特点,可能起到改善牙周病微生态的作用。本文从牙周相关疾病分类角度,对目前益生菌生态调节在牙周炎、牙龈炎、口腔异味及种植体周围疾病防治上的临床效应、作用机制及临床应用加以总结。

关键词: 牙周病, 益生菌, 临床效应, 机制, 临床应用

Abstract:

The initiating factor of periodontal diseases is plaque biofilm. In recent years, plaque hypothesis becomes increasingly inclined to the disruption of microbial homeostasis. Classic treatment method is mechanical plaque removal. However, individual differences exist in the curative effect, and some patients need to be assisted with other treatment methods. The role of probiotics in reconstructing host microbial community and regulating immune inflammatory responses may result in certain improvement in the microecology of periodontal diseases. This review summarises the clinical effects, mechanism and clinical application of probiotics for prevention and treatment of periodontitis, gingivitis, oral malodour and periimplant diseases from the perspective of the classification of periodontal diseases.

Key words: periodontal diseases, probiotics, clinical effect, mechanism, clinical application

中图分类号: 

  • R781.4
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