国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (1): 115-120.doi: 10.7518/gjkq.2020029

• 综述 • 上一篇    下一篇

黄连素的生物学功能及治疗口腔疾病研究的进展

崔钰嘉,孙建勋(),周学东   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙体牙髓病科 成都 610041
  • 收稿日期:2019-05-07 修回日期:2019-09-24 出版日期:2020-01-01 发布日期:2020-01-01
  • 通讯作者: 孙建勋 E-mail:jxsun@scu.edu.cn
  • 作者简介:崔钰嘉,博士,Email: 1214697348@qq.com
  • 基金资助:
    四川省科技支撑项目(2016RZ0035)

Progress for understanding the effect of berberine in oral diseases

Cui Yujia,Sun Jianxun(),Zhou Xuedong   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-05-07 Revised:2019-09-24 Online:2020-01-01 Published:2020-01-01
  • Contact: Jianxun Sun E-mail:jxsun@scu.edu.cn
  • Supported by:
    This study was supported by Sichuan Science and Technology Pillar Program(2016RZ0035)

摘要:

黄连素(小檗碱)是从黄连、三颗针、黄柏等天然药物中提取的异喹啉类生物碱,具有广泛的药理作用,能够有效地抗惊厥、抗高血压、抗肿瘤、抗抑郁、抗炎、降血脂、降血糖等。近年来,由于其丰富的生物学功能,人们逐渐发掘出黄连素用于治疗口腔疾病的潜力,研究其与龋病、根尖周炎、牙周病、口腔黏膜病、颌面部肿瘤的关系。本文就黄连素的生物学功能和其在口腔领域中的研究进展作一综述,为进一步研究黄连素在治疗口腔疾病的应用提供参考。

关键词: 黄连素, 龋病, 根尖周炎, 牙周炎, 口腔黏膜病, 肿瘤

Abstract:

Berberine is a benzylisoquinoline alkaloid, occurring as one of the main active ingredients in many traditional herbs including coptis, barberry, phellodendron. Several studies have depicted its anticonvulsant, antihypertensive, antidepressant, anti-inflammatory, hypolipidemic, and antidiabetic biological effect. Depending on a rich and varied biological function, the potential of berberine for curing oral diseases has been discovered recently. Researchers focus on the relation of berberine to oral diseases, such as periodontitis, caries, periapical periodontitis, diseases of oral mucosa, oral/maxillofacial. The review pays attention to the biological function of berberine as well as its roles in oral diseases.

Key words: berberine, caries, periapical periodontitis, periodontitis, diseases of oral mucosa, tumor

中图分类号: 

  • R78
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