国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (6): 680-686.doi: 10.7518/gjkq.2019091

• 综述 • 上一篇    下一篇

神经导向分子及其在口腔组织再生中的作用

孙兆泽1,2,3,刘双2,3,李纾1,2,3()   

  1. 1. 山东大学口腔医学院?口腔医院牙周科 济南 250012;
    2. 山东省口腔组织再生重点实验室 济南 250012
    3. 山东省口腔生物材料与组织再生工程实验室 济南 250012
  • 收稿日期:2019-04-19 修回日期:2019-08-09 出版日期:2019-11-01 发布日期:2019-11-14
  • 通讯作者: 李纾 E-mail:lishu@sdu.edu.cn
  • 作者简介:孙兆泽,硕士,Email: qweszz@163.com
  • 基金资助:
    山东省自然科学基金面上项目(ZR2019MH006)

Axon guidance molecules and their role in oral tissue regeneration

Sun Zhaoze1,2,3,Liu Shuang2,3,Li Shu1,2,3()   

  1. 1. Dept. of Periodontology, School and Hospital of Stomatology, Shandong University, Jinan 250012, China
    2. Shandong Key Laboratory of Oral Tissue Regeneration, Jinan 250012, China
    3. Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan 250012, China
  • Received:2019-04-19 Revised:2019-08-09 Online:2019-11-01 Published:2019-11-14
  • Contact: Shu Li E-mail:lishu@sdu.edu.cn
  • Supported by:
    This study was supported by Shandong Natural Science Foundation(ZR2019MH006)

摘要:

在神经发育过程中,神经导向分子以非常精确的方式引导轴突沿特定的路径生长延伸。随着对神经导向分子及其受体研究的不断深入,发现神经导向分子不仅能引导轴突生长,而且还能够通过多种信号通路广泛参与血管生成、骨再生甚至是口腔组织的发育和再生。这为研究和发展口腔疾病的治疗措施提供了新的思路。本文就目前发现的4类主要的神经导向分子(Slit、Semaphorin、Netrin和Ephrin)在组织再生尤其口腔组织再生中的相关作用进行综述。

关键词: 神经导向分子, 组织再生, 口腔组织再生

Abstract:

During the development of the nervous system, axon guidance molecules guide the axons to grow along a particular path in a very precise manner. With increasing research on axon guidance molecules and their receptors, results have demonstrated that axon guidance molecules do not only guide axon growth but also participate in angiogenesis, bone regeneration and the development and regeneration of oral tissues through various signalling pathways. Such work provides new ideas for the study and development of treatments for oral diseases. This article reviews the related roles of the four major axon guidance molecules (Slits, Semaphorins, Netrins and Ephrins) in tissue regeneration and oral tissue regeneration.

Key words: axon guidance molecule, tissue regeneration, oral tissue regeneration

中图分类号: 

  • Q136
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