国际口腔医学杂志

国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (6): 657-662.doi: 10.7518/gjkq.2019077

• 综述 • 上一篇    下一篇

蛋白酶激活受体在牙周组织细胞中相关作用的研究进展

卢可心1,张迪亚2,吴燕岷1   

  1. 1. 浙江大学医学院附属第二医院口腔内科 杭州 310009
    2. 浙江大学医学院附属邵逸夫医院牙科中心 杭州 310016
  • 收稿日期:2019-03-06 修回日期:2019-07-14 出版日期:2019-11-01 发布日期:2019-11-14
  • 作者简介:卢可心,学士,Email： 540604120@qq.com
  • 基金资助:
    国家自然科学基金(81000447);浙江省科学技术厅公益研究计划(LGF18H140003);浙江省自然科学基金(LY17H140002)

Research progress of protease-activated receptors on different types of cells in periodontal tissue

Lu Kexin1,Zhang Diya2,Wu Yanmin1   

  1. 1. Dept. of Oral Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China
    2. Dental Department, The Affiliated Sir Run Shaw Hospital, Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310016, China
  • Received:2019-03-06 Revised:2019-07-14 Online:2019-11-01 Published:2019-11-14
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81000447);Science and Technology Department Public Welfare Research Plan of Zhejiang Province(LGF18H140003);Natural Science Foundation of Zhejiang Province(LY17H140002)

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摘要：

蛋白酶激活受体是一种可被多种内源性和外源性蛋白酶激活,参与炎症反应且分布广泛的跨膜蛋白。国内外研究者主要阐述不同类型蛋白酶激活受体在牙周炎中的作用,尚未出现系统性分类陈述蛋白酶激活受体在牙周组织不同细胞中的作用。本文就蛋白酶激活受体分别在牙龈上皮细胞、牙龈成纤维细胞、成骨细胞、破骨细胞、免疫细胞等牙周组织不同细胞中的表达及与牙周炎相关作用等研究进展进行综述。

关键词: 蛋白酶激活受体, 牙龈上皮细胞, 牙龈成纤维细胞, 成骨细胞, 破骨细胞

Abstract: Protease-activated receptors (PARs), which are widely expressed transmembrane proteins, may induce inflammatory response once activated by a variety of endogenous and bacterial enzymes. Gingival epithelial cells, gingival fibroblasts, osteoblasts, osteoclasts, monocytes, macrophages and T lymphocytes exist in the periodontal tissue. In the development of periodontitis, the activated PARs of these cells are involved in the release of inflammatory factors and chemokines that cause gingival inflammation and alveolar bone destruction. Up-to-date data has shown the roles of PAR-1 and PAR-2 in periodontitis. However, the roles of PARs in hinge on different types of cells in the periodontal tissue have not been reviewed. Thus, the present review will focus on the current progress in the expression and functions of PARs.

Key words: protease-activated receptor, gingival epithelial cell, gingival fibroblast, osteoblast, osteoclast

中图分类号: 

  • Q26
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