国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (4): 437-441.doi: 10.7518/gjkq.2019050

• 综述 • 上一篇    下一篇

DNA甲基化与口腔疾病的研究进展

原振英1,管翠强2,南欣荣1,2()   

  1. 1. 山西医科大学口腔医学院·口腔医院 太原 030001;
    2. 山西医科大学第一医院口腔科 太原 030001
  • 收稿日期:2018-11-29 修回日期:2019-04-06 出版日期:2019-07-10 发布日期:2019-07-12
  • 作者简介:原振英,学士,Email: 853951775@qq.com
  • 基金资助:
    山西省卫生和计划生育委员会科研课题(2015026)

Research progress on DNA methylation and oral disease

Yuan Zhenying1,Guan Cuiqiang2,Nan Xinrong1,2()   

  1. 1. School and Hospital of Stomatology, Shanxi Medical University, Taiyuan 030001, China
    2. Dept. of Stomatology, First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2018-11-29 Revised:2019-04-06 Online:2019-07-10 Published:2019-07-12
  • Supported by:
    This study was supported by Scientific Research Project of Shanxi Health and Family Planning Commission(2015026)

摘要:

DNA甲基化现在被广泛认为是维持免疫细胞功能的关键。异常的DNA甲基化水平与常见的口腔疾病相关。环境因素和遗传多态性导致甲基化异常,影响某些免疫相关基因的表达,成为研究口腔疾病机制的热点。本文综述了在慢性牙周炎、口腔癌、口腔扁平苔藓等常见口腔疾病发展过程中异常甲基化的重要性,以及DNA甲基化与复发性阿弗他溃疡关系的研究展望,目的是更清楚地了解口腔疾病的发病机制,从而为治疗复杂性口腔疾病提供新的思路。

关键词: DNA甲基化, 慢性牙周炎, 口腔癌, 口腔扁平苔藓

Abstract:

DNA methylation is the key to maintaining the function of immune cells. Recent studies have shown that abnormal DNA methylation levels are significantly associated with common oral diseases. Environmental factors and genetic polymorphism lead to abnormal methylation and affect the expression of some immune-related genes. This paper reviewed the importance of abnormal DNA methylation in the development of common oral diseases (e.g. chronic periodontitis, oral cancer and oral lichen planus) and the relationship between DNA methylation and recurrent aphthous ulcer. This paper provides improved understanding of the pathogenesis of oral diseases and new insights into the treatment of oral diseases.

Key words: DNA methylation, chronic periodontitis, oral cancer, oral lichen planus

中图分类号: 

  • Q754
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