国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (2): 186-190.doi: 10.7518/gjkq.2019023

• 牙周专栏 • 上一篇    下一篇

炎症小体在牙周炎中的研究进展

吕慧欣1,杜留熠1,王鹞1,于维先2,任静宜1,顾芯铭1,周延民1()   

  1. 1.吉林大学口腔医院种植中心 长春 130021
    2.吉林省牙发育及颌骨重塑与再生省重点实验室 长春 130021
  • 收稿日期:2018-06-30 修回日期:2018-11-10 出版日期:2019-03-01 发布日期:2019-03-15
  • 通讯作者: 周延民 E-mail:Zhouym62@163.com
  • 作者简介:吕慧欣,硕士,Email: 125136701@qq.com
  • 基金资助:
    国家自然科学基金(81570983);吉林大学研究生创新基金资助项目(2017014)

Research progress on inflammasome in periodontitis

Huixin Lü1,Liuyi Du1,Yao Wang1,Weixian Yu2,Jingyi Ren1,Xinming Gu1,Yanmin Zhou1()   

  1. 1. Implant Center, Hospital of Stomatology, Jilin University, Changchun 130021, China
    2.Key Laboratory of Mechanism of Tooth Development and Jaw Bone Remodeling and Regeneration in Jilin Province, Changchun 130021, China)
  • Received:2018-06-30 Revised:2018-11-10 Online:2019-03-01 Published:2019-03-15
  • Contact: Yanmin Zhou E-mail:Zhouym62@163.com
  • Supported by:
    This study was supported by National Natural Science Fundation of China(81570983);Postgraduate Innovation Fund Project of Jilin University(2017014)

摘要:

炎症小体是存在于细胞质的多蛋白质复合物,参与机体的固有免疫反应,活化促炎因子白细胞介素-1β等介导了细胞的死亡,对炎症的进程有重要的调控作用。牙周炎是由多种牙周病致病菌(例如牙龈卟啉单胞菌)引起的炎性破坏性疾病。细菌菌体以及其毒性成分可以引发多种炎症小体的聚集组装,最终导致牙周组织的破坏等变化。本文将就机体发生牙周炎过程中炎症小体的产生和致病机制进行综述。

关键词: 牙周炎, 炎症小体, 细胞焦亡, 白细胞介素

Abstract:

Inflammasome is a multi-protein complex that exists in the cytoplasm and is involved in innate immune response. This multi-protein oligomer can activate proinflammatory cytokines such as interleukin-1β, mediate cell death, and regulate the progression of inflammation. Periodontitis is an inflammatory and destructive disease caused by various periodontal pathogens, such asPorphyromonas gingivalis. Bacteria and their toxic components can cause the assembly of various inflammasomes and eventually destroy periodontal tissues. This review focuses on the production of inflammasomes in periodontitis and its mechanism of causing diseases.

Key words: periodontitis, inflammasome, pyroptosis, interleukin

中图分类号: 

  • R781.4 +2
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