国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (2): 223-227.doi: 10.7518/gjkq.2019022

• 综述 • 上一篇    下一篇

软脑膜在外周炎症影响神经炎症过程中的作用

王鹞1,吕慧欣1,杜留熠1,顾芯铭1,任静宜1,于维先2,周延民1()   

  1. 1.吉林大学口腔医院种植中心 长春 130021
    2.吉林省牙发育及颌骨重塑与再生省重点实验室 长春 130021
  • 收稿日期:2018-06-13 修回日期:2018-12-10 出版日期:2019-03-01 发布日期:2019-03-15
  • 通讯作者: 周延民 E-mail:Zhouym62@163.com
  • 作者简介:王鹞,学士,Email: 547893076@qq.com
  • 基金资助:
    国家自然科学基金(81570983);吉林大学研究生创新基金(2017014);吉林省科技厅基础处白求恩医学专项资金(20160101138JC)

Roles of leptomeninges in the effect of chronic peripheral inflammation on neuroinflammation

Yao Wang1,Huixin Lü1,Liuyi Du1,Xinming Gu1,Jingyi Ren1,Weixian Yu2,Yanmin Zhou1()   

  1. 1. Dept. of Implant Center, Hospital of Stomatology, Jilin University, Changchun 130021, China
    2.Key Laboratory of Mechanism of Tooth Development and Jaw Bone Remodeling and Regeneration in Jilin Province, Changchun 130021, China
  • Received:2018-06-13 Revised:2018-12-10 Online:2019-03-01 Published:2019-03-15
  • Contact: Yanmin Zhou E-mail:Zhouym62@163.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81570983);Postgraduate Innovation Fund of Jilin University(2017014);Special Fund of Bethune Medicine, Basic Office of Science and Technology Department of Jilin Province(20160101138JC)

摘要:

阿尔茨海默病、帕金森病、额颞痴呆等慢性中枢神经退行性疾病的发病机制一直是学术界争论的热点问题。在这些疾病中,神经炎症是共有的特点。许多全身性疾病(如糖尿病、动脉粥样硬化及外周炎症)都与神经炎症的产生和加剧有关。越来越多的临床证据显示,一些常见的外周慢性炎症(如牙周炎等)与神经炎症的发生和发展有着密切的关系。近年来,一些学者的研究指出,软脑膜可能在这一相关性中起到了介导炎症信号传递的关键作用。本文就软脑膜在外周炎症影响神经炎症的过程中所起的作用进行综述,旨在进一步揭示神经炎症的病理过程,探究牙周炎和神经系统病变的内在联系,为众多慢性中枢神经退行性疾病的预防和治疗提供新途径。

关键词: 软脑膜, 神经炎症, 外周炎症, 牙周炎, 炎症信号

Abstract:

The pathogenesis of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease dementia and frontotemporal dementia, has remained controversial in academic circles. However, the presence of neuroinflammation is a common feature in these neurodegenerative diseases. Moreover, systemic diseases, such as diabetes, atherosclerosis and peripheral inflammation, are associated with the occurrence and exacerbation of neuroinflammation. Many pieces of clinical evidence showed a correlation between some common kinds of chronic peripheral inflammation, for instance periodontitis, and neurodegenerative disease. To date, some studies indicated that leptomeninges possibly plays as the courier who transfers systemic inflammatory signals in this connection. This review retrospectively analysed the role of leptomeninges in this potential connection between peripheral inflammation neuroinflammation, described the pathological process of neuroinflammation and elucidated the relation between neurodegenerative diseases and paradentitis to develop new therapies and prevention of neurodegenerative diseases.

Key words: leptomeninges, neuroinflammation, peripheral inflammation, periodontitis, inflammatory signal

中图分类号: 

  • R781.4 +2
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