国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (1): 55-61.doi: 10.7518/gjkq.2019.01.010

• 综述 • 上一篇    下一篇



  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙周科 成都 610041
  • 收稿日期:2018-01-14 修回日期:2018-04-11 出版日期:2019-01-01 发布日期:2019-01-11
  • 通讯作者: 丁一 E-mail:yiding2000@126.com
  • 作者简介:杨卓,硕士,Email:442198626@qq.com
  • 基金资助:

Research progress on salivary markers for diagnosis of aggressive periodontitis

Zhuo Yang,Shengdan Zhang,Chengcheng Liu,Yi Ding()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-01-14 Revised:2018-04-11 Online:2019-01-01 Published:2019-01-11
  • Contact: Yi Ding E-mail:yiding2000@126.com
  • Supported by:
    This study was supported by National Program on Key Basic Research Project (973 Program)(2013CBA0-1700);Natural Science Foundation of China(81371149);Natural Science Foundation of China(81600871)



关键词: 侵袭性牙周炎, 唾液, 微生物, 氧化应激, 蛋白质


Aggressive periodontitis is a specific form of periodontal disease with a high rate of progression and patterns of tissue destruction. This infection mostly affects young individuals and exhibits familial aggregation. Given the ability of salivary biomarkers to indicate the condition of soft tissues, bones and microorganisms in oral, salivary biomarkers may possess the potential to diagnosis and monitor aggressive periodontitis. Obtaining saliva can be low cost, noninvasive, simple and comfortable. Salivary biomarkers can be applied to early diagnosis and real-time monitoring of aggressive periodontitis. In this review, we summarise the research progression on salivary markers for aggressive periodontitis diagnosis to provide new ideas for diagnosis of such infection.

Key words: aggressive periodontitis, saliva, microbes, oxidative stress, protein


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