国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (1): 55-61.doi: 10.7518/gjkq.2019.01.010

• 综述 • 上一篇    下一篇

侵袭性牙周炎唾液诊断标记物的研究进展

杨卓,张盛丹,刘程程,丁一()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙周科 成都 610041
  • 收稿日期:2018-01-14 修回日期:2018-04-11 出版日期:2019-01-01 发布日期:2019-01-11
  • 通讯作者: 丁一 E-mail:yiding2000@126.com
  • 作者简介:杨卓,硕士,Email:442198626@qq.com
  • 基金资助:
    国家重点基础研究发展计划973计划项目(2013CBA0-1700);国家自然科学基金(81371149);国家自然科学基金(81600871)

Research progress on salivary markers for diagnosis of aggressive periodontitis

Zhuo Yang,Shengdan Zhang,Chengcheng Liu,Yi Ding()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-01-14 Revised:2018-04-11 Online:2019-01-01 Published:2019-01-11
  • Contact: Yi Ding E-mail:yiding2000@126.com
  • Supported by:
    This study was supported by National Program on Key Basic Research Project (973 Program)(2013CBA0-1700);Natural Science Foundation of China(81371149);Natural Science Foundation of China(81600871)

摘要:

侵袭性牙周炎是好发于青年人群,以进展迅速、破坏严重为特征,伴有家族聚集性的一类牙周炎。唾液中生物标记物能实时反映口腔软组织和硬组织、口腔内微生物的状态,在侵袭性牙周炎的诊断中有运用潜力,并可监测其活动状态。同时,唾液诊断具有廉价、无创、简便、舒适等优点。因此,唾液中的生物标记物有助于侵袭性牙周炎的早期诊断、实时监测。本文对侵袭性牙周炎唾液诊断标记物的研究现状进行综述,以期为侵袭性牙周炎唾液诊断提供思路。

关键词: 侵袭性牙周炎, 唾液, 微生物, 氧化应激, 蛋白质

Abstract:

Aggressive periodontitis is a specific form of periodontal disease with a high rate of progression and patterns of tissue destruction. This infection mostly affects young individuals and exhibits familial aggregation. Given the ability of salivary biomarkers to indicate the condition of soft tissues, bones and microorganisms in oral, salivary biomarkers may possess the potential to diagnosis and monitor aggressive periodontitis. Obtaining saliva can be low cost, noninvasive, simple and comfortable. Salivary biomarkers can be applied to early diagnosis and real-time monitoring of aggressive periodontitis. In this review, we summarise the research progression on salivary markers for aggressive periodontitis diagnosis to provide new ideas for diagnosis of such infection.

Key words: aggressive periodontitis, saliva, microbes, oxidative stress, protein

中图分类号: 

  • R781.4 +2
[1] Albandar JM . Aggressive periodontitis: case defini-tion and diagnostic criteria[J]. Periodontol 2000, 2014,65(1):13-26.
doi: 10.1111/prd.12014 pmid: 24738584
[2] Liu J, Duan Y . Saliva: a potential media for disease diagnostics and monitoring[J]. Oral Oncol, 2012,48(7):569-577.
doi: 10.1016/j.oraloncology.2012.01.021 pmid: 22349278
[3] Jaedicke KM, Preshaw PM, Taylor JJ . Salivary cyto-kines as biomarkers of periodontal diseases[J]. Perio-dontol 2000, 2016,70(1):164-183.
doi: 10.1111/prd.12117 pmid: 26662489
[4] Smith M, Seymour GJ, Cullinan MP . Histopatho-logical features of chronic and aggressive periodon-titis[J]. Periodontol 2000, 2010,53:45-54.
doi: 10.1111/j.1600-0757.2010.00354.x pmid: 20403104
[5] Van der Velden U . What exactly distinguishes aggre-ssive from chronic periodontitis: is it mainly a dif-ference in the degree of bacterial invasiveness[J]. Periodontol 2000, 2017,75(1):24-44.
doi: 10.1111/prd.12202 pmid: 28758297
[6] Taylor JJ . Protein biomarkers of periodontitis in sa-liva[J]. ISRN Inflamm, 2014,2014:593151.
doi: 10.1155/2014/593151 pmid: 4040190
[7] Proctor GB . The physiology of salivary secretion[J]. Periodontol 2000, 2016,70(1):11-25.
doi: 10.1111/prd.12116 pmid: 26662479
[8] Hajishengallis G . Periodontitis: from microbial im-mune subversion to systemic inflammation[J]. Nat Rev Immunol, 2015,15(1):30-44.
doi: 10.1038/nri3785 pmid: 4276050
[9] Yucel-Lindberg T, Båge T . Inflammatory mediators in the pathogenesis of periodontitis[J]. Expert Rev Mol Med, 2013,15:e7.
doi: 10.1017/erm.2013.8 pmid: 23915822
[10] Trindade F, Oppenheim FG, Helmerhorst EJ , et al. Uncovering the molecular networks in periodon-titis[J]. Proteomics Clin Appl, 2014,8(9/10):748-761.
doi: 10.1002/prca.201400028 pmid: 24828325
[11] Takahashi N . Oral microbiome metabolism: from “Who are they?” to “What are they doing?”[J]. J Dent Res, 2015,94(12):1628-1637.
doi: 10.1177/0022034515606045
[12] Baser U, Gamsiz-Isik H, Cifcibasi E , et al. Plasma and salivary total antioxidant capacity in healthy controls compared with aggressive and chronic periodontitis patients[J]. Saudi Med J, 2015,36(7):856-861.
doi: 10.15537/smj.2015.7.11954 pmid: 4503907
[13] Gümüş P, Nizam N, Nalbantsoy A , et al. Saliva and serum levels of pentraxin-3 and interleukin-1β in generalized aggressive or chronic periodontitis[J]. J Periodontol, 2014,85(3):e40-e46.
doi: 10.1902/jop.2013.130281 pmid: 23952075
[14] Elabdeen HR, Mustafa M, Szklenar M , et al. Ratio of pro-resolving and pro-inflammatory lipid mediator precursors as potential markers for aggressive perio-dontitis[J]. PLoS One, 2013,8(8):e70838.
doi: 10.1371/journal.pone.0070838 pmid: 3741366
[15] Nunes LA, Mussavira S, Bindhu OS . Clinical and diagnostic utility of saliva as a non-invasive diagno-stic fluid: a systematic review[J]. Biochem Med (Zagreb), 2015,25(2):177-192.
doi: 10.11613/BM.2015.018 pmid: 4470107
[16] Haririan H, Andrukhov O, Bertl K , et al. Microbial analysis of subgingival plaque samples compared to that of whole saliva in patients with periodontitis[J]. J Periodontol, 2014,85(6):819-828.
doi: 10.1902/jop.2013.130306 pmid: 24144271
[17] Könönen E, Müller HP . Microbiology of aggressive periodontitis[J]. Periodontol 2000, 2014,65(1):46-78.
doi: 10.1111/prd.2014.65.issue-1
[18] 冯向辉, 张立, 孟焕新 , 等. 牙周炎患者唾液中伴放线放线杆菌的检出状况分析[J]. 中华口腔医学杂志, 2008,43(7):402-405.
doi: 10.3321/j.issn:1002-0098.2008.07.007
Feng XH, Zhang L, Meng HX , et al. Prevalence of Actinobacillus actinomycetemcomitans in saliva of different types of periodontitis[J]. Chin J Stomatol, 2008,43(7):402-405.
doi: 10.3321/j.issn:1002-0098.2008.07.007
[19] López R, Dahlén G, Retamales C , et al. Clustering of subgingival microbial species in adolescents with periodontitis[J]. Eur J Oral Sci, 2011,119(2):141-150.
doi: 10.1111/j.1600-0722.2011.00808.x pmid: 21410554
[20] Li Y, Feng X, Xu L , et al. Oral microbiome in Chinese patients with aggressive periodontitis and their family members[J]. J Clin Periodontol, 2015,42(11):1015-1023.
doi: 10.1111/jcpe.12463 pmid: 26412568
[21] Saygun I, Nizam N, Keskiner I , et al. Salivary infec-tious agents and periodontal disease status[J]. J Perio-dont Res, 2011,46(2):235-239.
doi: 10.1111/j.1600-0765.2010.01335.x pmid: 21261620
[22] Bullon P, Newman HN, Battino M . Obesity, diabetes mellitus, atherosclerosis and chronic periodontitis: a shared pathology via oxidative stress and mitochon-drial dysfunction[J]. Periodontol 2000, 2014,64(1):139-153.
doi: 10.1111/j.1600-0757.2012.00455.x pmid: 24320961
[23] Ryder MI . Comparison of neutrophil functions in aggressive and chronic periodontitis[J]. Periodontol 2000, 2010,53:124-137.
doi: 10.1111/j.1600-0757.2009.00327.x pmid: 20403109
[24] Acquier AB, De Couto Pita AK, Busch L , et al. Pa-rameters of oxidative stress in saliva from patients with aggressive and chronic periodontitis[J]. Redox Rep, 2017,22(3):119-126.
doi: 10.1080/13510002.2016.1198104
[25] Baltacıoğlu E, Yuva P, Aydın G , et al. Lipid pero-xidation levels and total oxidant/antioxidant status in serum and saliva from patients with chronic and aggressive periodontitis. Oxidative stress index: a new biomarker for periodontal disease[J]. J Perio-dontol, 2014,85(10):1432-1441.
doi: 10.1902/jop.2014.130654 pmid: 24635543
[26] Villa-Correa YA, Isaza-Guzmán DM, Tobón-Arro-yave SI . Influence of periodontal clinical status on salivary levels of glutathione reductase[J]. J Perio-dontol, 2016,87(6):716-724.
doi: 10.1902/jop.2016.150618 pmid: 26777764
[27] Zamora-Perez AL, Ortiz-García YM, Lazalde-Ra-mos BP , et al. Increased micronuclei and nuclear abnormalities in buccal mucosa and oxidative damage in saliva from patients with chronic and aggressive periodontal diseases[J]. J Periodont Res, 2015,50(1):28-36.
doi: 10.1111/jre.12175 pmid: 24666368
[28] Ghallab N, Hamdy E, Shaker O . Malondialdehyde, superoxide dismutase and melatonin levels in gin-gival crevicular fluid of aggressive and chronic pe-riodontitis patients[J]. Aust Dent J, 2016,61(1):53-61.
doi: 10.1111/adj.12294
[29] Gümüş P, Nizam N, Lappin DF , et al. Saliva and serum levels of B-cell activating factors and tumor necrosis factor-α in patients with periodontitis[J]. J Periodontol, 2014,85(2):270-280.
doi: 10.1902/jop.2013.130117 pmid: 23701482
[30] Tobón-Arroyave SI, Jaramillo-González PE, Isaza-Guzmán DM . Correlation between salivary IL-1β levels and periodontal clinical status[J]. Arch Oral Biol, 2008,53(4):346-352.
doi: 10.1016/j.archoralbio.2007.11.005 pmid: 18155182
[31] Yue Y, Liu Q, Xu C , et al. Comparative evaluation of cytokines in gingival crevicular fluid and saliva of patients with aggressive periodontitis[J]. Int J Biol Markers, 2013,28(1):108-112.
doi: 10.5301/JBM.5000014 pmid: 23592001
[32] Nizam N, Gümüş P, Pitkänen J , et al. Serum and salivary matrix metalloproteinases, neutrophil elas-tase, myeloperoxidase in patients with chronic or aggressive periodontitis[J]. Inflammation, 2014,37(5):1771-1778.
doi: 10.1007/s10753-014-9907-0 pmid: 24799321
[33] 康军, 沙月琴, 陈智滨 . 不同牙周状况下唾液和龈沟液中弹性蛋白酶的含量[J]. 北京大学学报(医学版), 2012,44(1):17-21.
doi: 10.3969/j.issn.1671-167X.2012.01.004
Kang J, Shan YQ, Chen ZB . Granulocyte elastase levels in saliva and gingival crevicular fluid of sub-jects with various periodontal conditions[J]. J Peking Univ (Health Sci), 2012,44(1):17-21.
doi: 10.3969/j.issn.1671-167X.2012.01.004
[34] Aral CA, Köseoğlu S, Sağlam M , et al. Gingival crevicular fluid and salivary periostin levels in non-smoker subjects with chronic and aggressive perio-dontitis: periostin levels in chronic and aggressive periodontitis[J]. Inflammation, 2016,39(3):986-993.
doi: 10.1007/s10753-016-0328-0 pmid: 26931107
[35] Hägewald S, Bernimoulin JP, Köttgen E , et al. Salivary IgA subclasses and bacteria-reactive IgA in patients with aggressive periodontitis[J]. J Periodontal Res, 2002,37(5):333-339.
doi: 10.1034/j.1600-0765.2002.00337.x
[36] Fu Y, Korostoff JM, Fine DH , et al. Fcγ receptor genes as risk markers for localized aggressive perio-dontitis in African-Americans[J]. J Periodontol, 2002,73(5):517-523.
doi: 10.1902/jop.2002.73.5.517 pmid: 12027254
[37] Obayashi K . Salivary mental stress proteins[J]. Clin Chim Acta, 2013,425:196-201.
doi: 10.1016/j.cca.2013.07.028
[38] Haririan H, Bertl K, Laky M , et al. Salivary and serum chromogranin A and α-amylase in periodontal health and disease[J]. J Periodontol, 2012,83(10):1314-1321.
doi: 10.1902/jop.2012.110604 pmid: 22264209
[39] Kamin HS, Kertes DA . Cortisol and DHEA in deve-lopment and psychopathology[J]. Horm Behav, 2017,89:69-85.
doi: 10.1016/j.yhbeh.2016.11.018 pmid: 27979632
[40] Cakmak O, Tasdemir Z, Aral CA , et al. Gingival crevicular fluid and saliva stress hormone levels in patients with chronic and aggressive periodontitis[J]. J Clin Periodontol, 2016,43(12):1024-1031.
doi: 10.1111/jcpe.12614 pmid: 27513682
[41] Mestnik MJ, Feres M, Figueiredo LC , et al. The effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized aggressive perio-dontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial[J]. J Clin Periodontol, 2012,39(10):955-961.
doi: 10.1111/j.1600-051X.2012.01932.x pmid: 22882646
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