国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (6): 710-715.doi: 10.7518/gjkq.2018.06.015

• 综述 • 上一篇    下一篇

唾液组学在口腔癌诊断中的应用

李倩,张平,陈娇,曾昕,冯云()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医学院 成都 610041
  • 收稿日期:2017-12-29 修回日期:2018-04-17 出版日期:2018-11-01 发布日期:2018-11-15
  • 通讯作者: 冯云 E-mail:953463551@qq.com
  • 作者简介:李倩,硕士,Email: 996462491@qq.com
  • 基金资助:
    国家自然科学基金(81372892);四川省科技厅平台建设项目(JCPT2011-9)

Progress of salivaomics in diagnosis of oral cancer

Qian Li,Ping Zhang,Jiao Chen,Xin Zeng,Yun Feng()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-12-29 Revised:2018-04-17 Online:2018-11-01 Published:2018-11-15
  • Contact: Yun Feng E-mail:953463551@qq.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81372892);Sichuan Province Science and Technology Innovation Team Program(JCPT2011-9)

摘要:

人类对唾液的探索有悠久的历史,其无创、快捷、安全、廉价等优势得到了大量学者的青睐。最新提出的唾液组学包含了唾液基因组学、转录组学、蛋白质组学、代谢组学、微生物组学及微小RNA等,其中储存的人类及口腔微生物的生物信息为各种口腔疾病以及全身系统性疾病的研究提供了重要信息。唾液与口腔癌所特有的解剖生理关系使得唾液组学与口腔癌关系的研究成为热点。大量研究试图通过检测唾液中的口腔癌生物标志物对口腔癌进行无创诊断,目前已有许多口腔癌生物学标志物在唾液中被相继发现。本文就唾液组学及其在口腔癌诊断中的应用进行综述。

关键词: 唾液, 唾液组学, 口腔癌, 诊断

Abstract:

Saliva analysis has long been considered a potential alternative to blood serum and urine analyses. This body fluid is gaining popularity due to its ease of collection, safety in handling, low cost and high efficiency. Salivaomics includes six diagnostic alphabets: salivary genomics, transcriptomics, proteomics, metabolomics, microbiomics and microRNA (miRNA). Saliva contains extensive biological information, thereby playing important role in the early diagnosis of oral disorder and several systemic diseases. Direct contact between saliva and oral cancer lesions makes measurement of tumour markers in saliva an attractive alternative to serum testing. Salivaomics may offer a robust alternative for clinicians in making clinical decision in the future. This article provides an updated review on the progress of salivaomics in oral cancer diagnosis.

Key words: saliva, salivaomics, oral cancer, diagnosis

中图分类号: 

  • R333.1
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