国际口腔医学杂志

国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (5): 523-527.doi: 10.7518/gjkq.2017.05.006

• 牙周专栏 • 上一篇    下一篇

表观遗传学及其调控与牙周病

刘双, 李纾   

  1. 山东大学口腔医院牙周科,山东省口腔组织再生重点实验室 济南 250012
  • 收稿日期:2016-11-23 修回日期:2017-05-26 出版日期:2017-09-01 发布日期:2017-09-01
  • 通讯作者: 李纾,教授,博士,Email：lishu@sdu.edu.cn
  • 作者简介:刘双,硕士,Email：1032642912@qq.com

The effect of epigenetics and its regulation on periodontal disease

Liu Shuang, Li Shu.   

  1. Dept. of Periodontics, Hospital of Stomatology, Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan 250012, China
  • Received:2016-11-23 Revised:2017-05-26 Online:2017-09-01 Published:2017-09-01

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摘要： 表观遗传学是指不涉及DNA序列改变,而是通过有丝分裂和减数分裂进行遗传的基因表达变化的遗传学分支学科,其调控机制主要包括DNA甲基化、组蛋白修饰、染色质重塑和非编码RNA调控等。牙周炎病因复杂,且被吸收、破坏的牙槽骨很难实现功能性再生。表观遗传学在导致炎症的发生及促进骨再生的过程中扮演着重要角色,从表观遗传学及其调控的角度来预防牙周病的发生,促进牙槽骨的功能性再生,将是未来重要的研究内容,具有重要的临床意义。

关键词: 表观遗传学, 牙周病, 牙槽骨再生

Abstract: Epigenetics is defined as not involved in the change of the DNA sequence, but through mitosis and meiosis of the genetic changes in the genetics of the field, and its regulatory mechanisms include DNA methylation, histone modification, chromatin remodeling and non-encoding RNA regulation. The pathogeny of periodontal disease is complex, and it is difficult to achieve functional regeneration of alveolar bone. Epigenetic plays an important role in the development of inflammation and the promotion of bone regeneration. It will be an important research field in the future and have important clinical significance to prevent the occurrence of periodontal disease and make the functional regeneration of alveolar bone possible from the perspective of the epigenetic and its regulation.

Key words: epigenetics, periodontics, alveolar bone regeneration

中图分类号: 

  • R781.4
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