Table of Content

    20 May 2009, Volume 36 Issue 3 Previous Issue    Next Issue
    Original Articles
    Anesthesia management for radioactive seed implantation in treatment of oral and
    YANG Xu-dong, DONG Wen, ZHANG Jian-guo
    Inter J Stomatol. 2009, 36 (3):  253-255,259.  DOI: 10.3969/j.issn.1673-5749.2009.03.001
    Abstract ( 1853 )   HTML ( 6 )   PDF(pc) (156KB) ( 800 )   Save
    Objective To investigate characteristics of anesthesia management for radioactive seed implantation in treatment of oral and maxillofacial malignant tumor. Methods 76 patients with oral and maxillofacial malignant tumor receiving treatment of radioactive seed implantation were given three types of anesthesia according to indications: Local anesthesia plus intravenous sedation(group LA), general anesthesia with endotracheal intubation(group TT) and general anesthesia with laryngeal mask airway(group LMA). Changes of patients′ blood pressure(BP), heart rate(HR) and saturation of pulse oxygen(SpO2) during operation were recorded. Characteristics of anesthesia
    induction and maintenance and perioperative complications were observed. Results Among the 76 patients, 12 patients were enrolled into group LA, 24 patients were enrolled into group TT and 40 patients were enrolled into
    group LMA. Perioperative cardiovascular response in group LA was more intense than that in group TT and group LMA(P<0.05). The lowest SpO2 during operation of group LA was lower than preoperative value and than that of group TT and group LMA(P<0.05). Patients in group LA had more body movements and more pain than that in group TT and group LMA(P<0.05). One patient of group LA had hypoxemia during operation. In group TT, 9
    patients had difficult intubation and the successful rate of first insertion was 62.5%. One patient of group TT received emergency tracheotomy because of postoperative airway obstruction. The successful rate of first insertion in
    group LMA was 90%. There was no difference between group TT and group LMA with respect to cardiovascular change and lowest SpO2. 9 patients of group LMA showed leakage during operation but no hypoxemia occurred.
    Conclusion In maxillofacial radioactive seed implantation surgery, different anesthesia methods should be chosen according to indications. Local anesthesia plus intravenous sedation is not likely to produce perfect analgesia, while general anesthesia with endotracheal intubation may
    have difficult intubation. Laryngeal airway mask is easy to insert and can be used under safety and feasibility in such operations.
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    Clinical evaluation of dentine sensitivity after scaling and root planing
    GONG Yi-ming, DING Xiao-jun, REN Ying
    Inter J Stomatol. 2009, 36 (3):  256-259.  DOI: 10.3969/j.issn.1673-5749.2009.03.002
    Abstract ( 2445 )   HTML ( 7 )   PDF(pc) (191KB) ( 923 )   Save
    Objective To evaluate the prevalence and intensity of dentine sensitivity(DS) after scaling and root planing. Methods The study was carried out with 38 subjects who had chronic periodontitis requiring for scaling and root planing. DS was scored by the subjects on a 0-10 visual analogue scale(VAS) after cold air stimulation of the test teeth at baseline and 5 minutes after the treatment, 1 week after the treatment and 4 weeks after the treatment. The prevalence and intensity of DS was compared between the baseline and post -treatment. Results There was a significant increase in the prevalence of DS after 1 week after the treatment(52.6%) compared to baseline data(28.9%, P<0.05). The VAS of sensitive teeth 1 week after the treatment(4.1±1.7) was also significantly higher than that at baseline(2.9±1.7, P<0.05). The prevalence and intensity of DS showed statistical decrease 4 weeks after the treatment, no significant difference was found compared with baseline(P>0.05). Conclusion
    Scaling and root planing may play a role in the etiology of dentine sensitivity.
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    The diagnosis and treatment of basal cell naevus syndrome
    WANG Yin , GUO Jing-jie, YANG Jun, SUN Geng-lin, LI Long-jiang
    Inter J Stomatol. 2009, 36 (3):  260-262.  DOI: 10.3969/j.issn.1673-5749.2009.03.003
    Abstract ( 2883 )   HTML ( 4 )   PDF(pc) (196KB) ( 840 )   Save
    Objective The purpose of this study was to evaluate the clinical manifestation, diagnosis and treatment of basal cell naevus syndrome(BCNS). Methods Reviewed the procedure of diagnosis and treatment by analyzing the records of 4 inpatients of BCNS in General Hospital Affiliated to Tianjin Medical University from 1999 to 2007. Results The inpatients characterized with typical facial features, cutaneous basal cell naevus(carcinoma) were obviously seen on the skin, palmar or plantar pits were viewed, bilamellar calcification of falx cerebri, bifid, fused or markedly splayed ribs were found, and histologically confirmed odontogenic keratocysts of jaw could be detected in most cases of BCNS. No family history was found in all cases of the group. Conclusion
    Multiple odontogenic keratocysts of jaw is one of the most important clinical manifestation of BCNS. The correct and prompt treatment will provide the patients with better life quality.
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    Dentoskeletal and soft tissue profile changes after maxillary
    YE Jin-mei, DENG Li-qin, ZHAI Jia-yu, JIANG Jie, WANG Hong-tao, DENG Xi-he
    Inter J Stomatol. 2009, 36 (3):  263-266.  DOI: 10.3969/j.issn.1673-5749.2009.03.004
    Abstract ( 1593 )   HTML ( 7 )   PDF(pc) (223KB) ( 812 )   Save
    Objective To evaluate the changes of dentoskeletal and soft tissue profile of the patients with skeletal class Ⅲ after maxillary protraction with rapid expansion in the primary class Ⅲ dentition. Methods Eight patients with serious skeletal class Ⅲ, 5 males and 3 females, in the primary dentition were selected. The patients present with a concave facial profile, anterior or posterior crossbite. No apparent mandibular displacement was found in all patients. Cephalograms were taken before and after maxillary protraction with expansion. Results The maxillary was protracted significantly, whereas the mandible was positioned backward significantly, with a concomitant decrease in the skeletal facial angle. The corresponding soft tissue changes displayed significant decrease in soft tissue facial angle, the skeletal and soft tissue profile showed similar increases in lower facial height. The maxillary incisors tipped labially, while the mandibular incisors tipped lingually. Lip structure changed with increased upper lip convesity and decreased lower lip convexity, the inclination of the upper and the lower lip decrease significantly. Conclusion This treatment shows that significant dentoskeletal and soft tissue changes and improvements in dentofacial profile result from 6 months of treatment with maxillary expansion and protraction.
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    Clinical evaluation of rotary ProTaper in preparation of root canal during retrea
    LI Yan, ZHAO Jin, SUN Yu-liang, NIU Qiao-li
    Inter J Stomatol. 2009, 36 (3):  267-269.  DOI: 10.3969/j.issn.1673-5749.2009.03.005
    Abstract ( 1857 )   HTML ( 10 )   PDF(pc) (114KB) ( 1415 )   Save
    Objective To assess the clinical effect of rotary ProTaper in preparation of root canal during retreatment. Methods A total of 120 teeth which needed endodontic retreatmemt were selected and randomly divided into 2 groups with 60 teeth in each group. The root canals were prepared with rotary ProTaper and crown-down technique in experimental group(PT) and K-files with step-back technique in control group(HF), respectively. And both filled with cold lateral condensation technique. To record the prepared time and numbers of postoperative complications, and according to X-ray of pre-therapy and post-therapy to estimate the effect of root canal preparation and filling. Results The time of preparation in PT group was obviously shorter than HF group. The
    effect of root canal shaping and filling in PT group was better than that in HF group. There were 3 fractured instruments in PT group. Conclusion Rotary ProTaper showed high performance, better shaping ability and effective
    obturation, but we should pay attention to prevent instrumental fracture.
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    Effect on incidence of cleft palate interfered by different do
    HE Wei , LU Sheng -jun , LI Cheng -hao , MENG Tian , ZHOU Jing -lin , SHI Bing
    Inter J Stomatol. 2009, 36 (3):  270-272.  DOI: 10.3969/j.issn.1673-5749.2009.03.006
    Abstract ( 1886 )   HTML ( 7 )   PDF(pc) (120KB) ( 1309 )   Save
    Objective To define the optimal dose of dexamethasone induced cleft palate in C57BL/6J mice and to provide a reliable model of cleft palate for further study. Methods Pregenant mice at specific period were divided into five groups randomly, that were control group and experimental groups of Ⅰ, Ⅱ, Ⅲ, Ⅳ. The mice of the control group were injected sodium chloride 0.1 mL and the mice of experimental Ⅰ, Ⅱ, Ⅲ, Ⅳ groups were injected dexamethasone of 12.0, 6.0, 3.2, 1.6 mg/kg respectively at 8:00 am on embryo 10 to embryo 12. To weigh
    pregnant mice and embryos and record the number of embryonic resorption and cleft palate after pregnant mice were killed on embryo 17.5. Results Weight of pregnant mice was significantly different(P<0.05), but the number of embryonic resorption and cleft palate had no significant difference between control group and experimental Ⅲ, Ⅳ groups(P > 0.05). Incidence of embryonic cleft palate had significant difference between control group and
    experimentalⅠ,Ⅱgroups(P<0.05). However, incidence of embryonic resorption increased significantly in experimental Ⅰgroup(P<0.05). There was no difference in embryonic weight among each group(P>0.05). Conclusion 6.0 mg/kg is the optimal dose of dexamethasone to induce cleft palate in C57BL/6J mice.
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    Dental age assessment using Demirjian′s method on Chengdu children aged from eig
    CHEN Jian-wei, LIU Ze-ping, GUO Jing, LIU Ren-kai, CHEN Ting-ting, ZOU Shu-juan
    Inter J Stomatol. 2009, 36 (3):  273-275.  DOI: 10.3969/j.issn.1673-5749.2009.03.007
    Abstract ( 1663 )   HTML ( 5 )   PDF(pc) (118KB) ( 757 )   Save
    Objective To evaluate the applicability of Demirjian′s method for dental age estimation in Chengdu children, aged from 8 to 16, and to modify it if needed. Methods Demirjian′s method was used to assess the dental maturity score and dental age of 445 Chengdu children. The differences between dental age and chronological age were compared using paired t -test. The nonlinear regression method was used to establish the logistic model between the dental maturity scores and chronological age. Results The mean differences between dental age and chronological age were 0.67 years in female and 0.52 years in male. The logistic model of the dental maturity scores and chronological age was an exponential model. Conclusion Demirjian's method need to be modified
    to be used in dental age assessment of Chengdu children.
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    Evaluation about the effects of non -extraction treatment for patients of differe
    ZAN Lin, LIN Bao-shan, DENG Xiao, CHEN Song
    Inter J Stomatol. 2009, 36 (3):  276-280.  DOI: 10.3969/j.issn.1673-5749.2009.03.008
    Abstract ( 1691 )   HTML ( 6 )   PDF(pc) (181KB) ( 936 )   Save
    Objective To evaluate the optimal time for fixed appliance treatment and the relation between orthodontic treatment and growth of Angle class Ⅱ division 1 malocclusion during growth periods. Methods 60 patients with Angle class Ⅱ division 1 malocclusion were selected according to the cervical vertebral maturation (CVM) method for the assessment of mandibular growth made by Baccetti, including non-extraction group and control group in the growth peak, and non-extraction group and control group after growth peak. The number of
    male and female in each group was the same. All the lateral cephalometric photos before and after treatment were analyzed. Results Soft and hard tissues had been changed after treatment. The bone effect of non -extraction
    group in the growth peak after treatment was better than the non-extraction group after the growth peak(P<0.05), but no statistically significant difference was found in most parts of teeth and soft tissues between the two groups (P>0.05). Conclusion The development of maxilla is restrained and the growth of mandible and chin is stimulated after non-extraction treatment of Angle class Ⅱ division 1 malocclusion during growth period. In order to get a better bone effect, treatment should be given as early as possible in the growth peak.
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    Changes of hard tissues of patients with Angle class Ⅱ division 1 malocclusion b
    NA Bin, BAI Xue-qin, LIU Xue-heng
    Inter J Stomatol. 2009, 36 (3):  281-284.  DOI: 10.3969/j.issn.1673-5749.2009.03.009
    Abstract ( 1463 )   HTML ( 6 )   PDF(pc) (138KB) ( 1071 )   Save
    Objective The study was to investigate the changes of hard tissues of patients with Angle class Ⅱ division 1 malocclusion by Damon-Ⅲ and MBT technique. Methods The sample consisted 20 patients with Angle class Ⅱ division 1 malocclusion by MBT technique and 20 patients with Angle class Ⅱ division 1 malocclusion by Damon-Ⅲ technique. All of them were extracted all the first premolars and without any other anchorage appliances added. The pre- and after-treatment cephalometric films were measured to assess the treatment effect. Results After treatment, the maxilla and mandible in two groups did not change significantly in sagittal direction, but had the trend to increase in vertical. The dental measurement were changed but had a little bit of difference
    between two groups. Conclusion Good results could be obtained in patients with Angle class Ⅱ division 1 malocclusion by using Damon-Ⅲ and MBT technique. Anchorage could be controlled successfully in two groups. But
    the anterior tooth torque control is dissatisfactory in Damon-Ⅲ technique group.
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    The clinical analysis of 2×4 corrective technique applied in correcting the ante
    CUI Zhou-ying, LAI Wen-li, JIANG Xing-ke, ZHANG Ying-min
    Inter J Stomatol. 2009, 36 (3):  285-287.  DOI: 10.3969/j.issn.1673-5749.2009.03.010
    Abstract ( 1526 )   HTML ( 5 )   PDF(pc) (165KB) ( 1260 )   Save
    Objective To discuss the clinical effects and characteristics of 2×4 corrective technique applied in correcting the anterior crossbite during the mixed dentition. Methods The 2×4 corrective technique and biteplate of posterior upper teeth as well as Class Ⅲ elastic force was applied to correct the anterior crossbite of mixed dentition. Results This method was able to correct the anterior crossbite and also to reduce the time of treatment and to spare the frequency of seeing the doctor again. Conclusion 2 ×4 corrective technique is an effective method of correcting the anterior crossbite during the mixed dentition and is valuable to spread.
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    Case Report
    Root canal therapy for taurodontism: A case report and literature review
    SHAO Mei -ying, ZHENG Guang -ning, HU Tao
    Inter J Stomatol. 2009, 36 (3):  288-290.  DOI: 10.3969/j.issn.1673-5749.2009.03.011
    Abstract ( 2502 )   HTML ( 10 )   PDF(pc) (211KB) ( 1061 )   Save
    Taurodontism is characterized by larger pulp champer, decreased root length and less marked cervical constriction. It has also been associated with several syndromes and anomalies, however, it most frequently appears as an isolated anomaly. A failure of Hertwig′s epithelial root sheath to invaginate at the appropriate horizontal level shed important light on the pathogenesis of taurodontism. To date, the etiopathogenesis of taurodontism is unclear.
    When these teeth are infected by endodontitis or apical periodontitis, root canal therapy is still the best choice. One case of taurodontism was reported and relevant literatures were reviewed. The possible etiology and treatment of taurodontism was discussed.
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    Effects of the chitosan and its derivatives on the cariogenic bacteria
    JING Jun-jun, HAO Yu-qing
    Inter J Stomatol. 2009, 36 (3):  291-293.  DOI: 10.3969/j.issn.1673-5749.2009.03.012
    Abstract ( 1636 )   HTML ( 4 )   PDF(pc) (112KB) ( 1174 )   Save
    Chitosan is a unique degradable polymer of biological activity. The recent study found that chitosan had a variety of physiological effects, in particular, having a good antibacterial activity. This article summarized its effects on the growth of bacteria, the adhesion of bacteria and the plaque pH value, also the affecting factors of its antibacterial activity.
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    Research progress on migration of dental pulp cells
    YANG Hui, HU Tao
    Inter J Stomatol. 2009, 36 (3):  294-296.  DOI: 10.3969/j.issn.1673-5749.2009.03.013
    Abstract ( 1374 )   HTML ( 5 )   PDF(pc) (112KB) ( 973 )   Save
    Defensive reaction is initiated when the pulp is suffered from potential harmful stimulus. Secreting or releasing cytokines constructs a complex regulatory network to activate certain signaling pathways, resulting in reparative dentin formation to protect the pulp from noxious stimulus. The directional migration of dental pulp cells to the injured sites is pivotal to the regeneration process. This review focused on the research progress in migration of dental pulp cells.
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    Research progress and assessment of laser fluorescence method for early caries de
    LI Xiao -lan, LING Jun-qi
    Inter J Stomatol. 2009, 36 (3):  297-299,302.  DOI: 10.3969/j.issn.1673-5749.2009.03.014
    Abstract ( 1458 )   HTML ( 4 )   PDF(pc) (132KB) ( 678 )   Save
    Dental caries is a progressive disease and deficiency in which multiple factors coactivate to hard tissue of the tooth. It reflects as demineralization of calcified tissue and disintergration of organic material, and progresses from color-changing to substantial cavity. The detection of early caries is a key element in the prevention and treatment of dental caries. Laser fluorescence is a new diagnostic tool to detect and quantify caries based on the principle that carious dental tissues emit higher fluorescence than sound tissue. With its higher sensitivity, accuracy and reliability than conventional diagnostic methods and non-invasive technique, laser fluorescence is considered to be an effective adjunct tool for early caries detection. This article intended to review its principle, diagnostic value, clinical application and influencing factors.
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    Present study of physiologic root resorption in primary teeth
    WANG Jiao-cui, ZHAO Wei
    Inter J Stomatol. 2009, 36 (3):  300-302.  DOI: 10.3969/j.issn.1673-5749.2009.03.015
    Abstract ( 1710 )   HTML ( 5 )   PDF(pc) (114KB) ( 1282 )   Save
    Primary root resorption is a physiological event for the primary teeth and plays an important role during normal replacement procedure. The structure and functions of odontoclast during primary root resorption and the related enzymes were summarized in this article.
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    The role of core binding factor α1 in periodontal tissue during the orthodontic
    HE Qi, CHEN Dan-peng, PAN Jin-song
    Inter J Stomatol. 2009, 36 (3):  303-306.  DOI: 10.3969/j.issn.1673-5749.2009.03.016
    Abstract ( 1533 )   HTML ( 3 )   PDF(pc) (150KB) ( 925 )   Save
    Core binding factor α1(Cbfα1) has been identified as a key regulator of osteoblast differentiation and bone formation, a osteoblast-specific ranscription factor in osteoblast genesis and differentiation. Cbfα1 participates in the tissues remodeling during orthodontic tooth movement and plays an important role in the remodeling of periodontal tissue.
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    Reconsideration of calcium hydroxide as an intracanal medication
    ZHONG Su-lan, YIN Shi-hai
    Inter J Stomatol. 2009, 36 (3):  307-309.  DOI: 10.3969/j.issn.1673-5749.2009.03.017
    Abstract ( 1836 )   HTML ( 18 )   PDF(pc) (112KB) ( 3023 )   Save
    Calcium hydroxide(CH) is used mostly as an intracanal medication in clinical situations. The disinfection of CH has been widely acknowledged. However, the current studies show that CH is not effective against for all bacteria, especially the root canal flora of refractory apical periodontitis, the antibacterial efficacy is not expected. The medicaments and clinical operation may influence the antibacterial efficacy.
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    Photo-activated disinfection and its application in the treatment of root canal i
    QI Yi-pin, LING Jun -qi
    Inter J Stomatol. 2009, 36 (3):  310-312.  DOI: 10.3969/j.issn.1673-5749.2009.03.018
    Abstract ( 1838 )   HTML ( 4 )   PDF(pc) (108KB) ( 733 )   Save
    Photo-activated disinfection(PAD), also known as photodynamic therapy or light-activated antimicrobial chemo-therapy, involves the use of a photoactive dye(photosensitizer) that is activated by exposure to light of a specific wavelength in the presence of oxygen. It is endowed with several favorable features for the treatment of infection in root canals, including a broad spectrum of antibacterial effect, the localization of its action, and the efficient inactivation of antibiotic-resistant strains. PAD provides an alternative approach to controlling root canal infection. This review summarized the mechanism of PAD and researches on its application in the inactivation of root canal bacteria.
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    Advancement of cell adhesion molecules in periodontal diseases
    MAO Xue -li, LING Jun -qi
    Inter J Stomatol. 2009, 36 (3):  313-315.  DOI: 10.3969/j.issn.1673-5749.2009.03.019
    Abstract ( 1635 )   HTML ( 3 )   PDF(pc) (108KB) ( 874 )   Save
    Different populations of cells are involved in the activity of inflammatory and immune responses. Cell adhesion molecules are proteins which locate on cell surface or in the surrounding of cell and mediate the contact of cell-cell or cell-matrix. In this review we summarized the structure, distribution, and function of cell adhesion molecules involved in the periodontal diseases.
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    Clinical research model of the psychosocial factors contributing to periodontal d
    LI Quan, XU Chun-jiao
    Inter J Stomatol. 2009, 36 (3):  316-318.  DOI: 10.3969/j.issn.1673-5749.2009.03.020
    Abstract ( 1507 )   HTML ( 4 )   PDF(pc) (106KB) ( 906 )   Save
    Along with the transformation of medical pattern from the traditional biomedical model to the biopsychosocial medical model, social psychic factors may contribute to the onset, progress, treatment and prognosis of the periodontal disease. Based on the latest clinical studies of the relationship between psychosocial factors and periodontal disease, psychological measurements, characteristics of the periodontal outcome measures, research design and the statistical analysis and control of the confounding factors were concretely demonstrated in this review, which made it convenient to further explore the etiological relationship between the psychosocial factors and the periodontal disease in clinical study.
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    Roles of 4-1BB and 4-1BB ligand in oral cancer immunotherapy
    SUN Shun-tao, YANG Hong-yu
    Inter J Stomatol. 2009, 36 (3):  319-322.  DOI: 10.3969/j.issn.1673-5749.2009.03.021
    Abstract ( 1371 )   HTML ( 4 )   PDF(pc) (140KB) ( 751 )   Save
    4-1BB and 4-1BB ligand(4-1BBL) are members of the tumor necrosis factor/tumor necrosis factor receptor family, which are expressed on T cells and antigen-presenting cells (APC) respectively. In recent study, therapies utilizing the 4-1BB/4-1BBL signaling pathway have been shown to have antitumor effects in a number of model systems. In this report, we focus solely on the role of 4-1BB and its receptor 4-1BBL in costimulation and discuss its potential as a target for the immunotherapy of oral cancer.
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    Research progress on the role of environmental factors in the etiology of non-Hod
    LI Xin, LI Long-jiang
    Inter J Stomatol. 2009, 36 (3):  323-325.  DOI: 10.3969/j.issn.1673-5749.2009.03.022
    Abstract ( 1447 )   HTML ( 3 )   PDF(pc) (106KB) ( 1040 )   Save
    The last thirty years saw a rise in the incidence of non-Hodgkin lymphoma, and it is now one of the most common neoplasms. Lymphomagenesis is a complex process and that many of the pathologic subtypes of lymphoma have different etiologies. Thus, the study of environmental factors becomes more and more important. This paper reviewed the research advance on the role of environmental factors in the etiology of non-Hodgkin lymphoma.
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    Matrix extracelluar phosphoglycoprotein and its important fragments
    ZHOU Xiao-yan, WEI Xi
    Inter J Stomatol. 2009, 36 (3):  326-328,331.  DOI: 10.3969/j.issn.1673-5749.2009.03.023
    Abstract ( 1624 )   HTML ( 4 )   PDF(pc) (143KB) ( 806 )   Save
    Matrix extracelluar phosphoglycoprotein(MEPE), which is one of the matrix extracelluar non-collagenous proteins, is expressed in bone, teeth and renal proximal convoluted tubules. It is considered to be a potential phosphatonin. And it plays an important role in bone formation and mineralization. ARASM fragments and dentonin/AC-100, motifs derived from MEPE, are the focus of recent research.
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    The correlation of cyclophilin A with oral squamous cell cancer
    MA Lan, SHEN Shi-qian, WANG Zhen, ZHANG Wei-wei, CAO Zheng-guo
    Inter J Stomatol. 2009, 36 (3):  329-331.  DOI: 10.3969/j.issn.1673-5749.2009.03.024
    Abstract ( 1774 )   HTML ( 3 )   PDF(pc) (108KB) ( 1037 )   Save
    Cyclophilin A is a group of highly conserved proteins and it generally presents in many kinds of cells. Cyclophilin A has many biological functions and plays an important role in the pathophysiologic process. Cyclophilin A could participate in the tumorgenesis, invasion, cell proliferation, vascular growth of oral squamous
    cell carcinoma, which was reviewed in the paper.
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    Research progress of emdogain in the field of stomatology
    ZHANG Li-juan, ZHAO Shi-fang
    Inter J Stomatol. 2009, 36 (3):  332-334.  DOI: 10.3969/j.issn.1673-5749.2009.03.025
    Abstract ( 1607 )   HTML ( 4 )   PDF(pc) (109KB) ( 1095 )   Save
    Emdogain is the conjugate of enamel matrix derivative and corresponding carrier, which can promote regeneration of periodontal tissues, biomineralization, bone induction and so on. Many researchers reached some results in emdogain from culture in vitro, animal studies and clinic trials. This review summarized emdongain and its role in periodontal disease, maxillofacial defects, dental implantation and so on.
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    Mechanism of bone morphogenetic protein/Smad singaling pathway and its response t
    CHENG Zong-sheng, GUAN Jian
    Inter J Stomatol. 2009, 36 (3):  335-337.  DOI: 10.3969/j.issn.1673-5749.2009.03.026
    Abstract ( 1671 )   HTML ( 4 )   PDF(pc) (118KB) ( 646 )   Save
    Bone morphogenetic protein(BMP), one of multifunctional secreted signaling molecules, is a member of the transforming growth factor-β superfamily. BMP regulates a wide spectrum of cellular functions such as proliferation, differentiation, migration and apoptosis, and also plays central roles in morphogenesis of various organs, embryonic development as well as reparation of injured tissues. Smad(sma-mad) protein is intracellular signaling
    transduction and regulatory molecules of BMP. Signal transduction studies have revealed that Smad can transduce the BMP signal from the cellmembrane to the nucleus, forming the BMP/Smad singaling pathway. Recently, researches
    have show that BMP/Smad singaling pathway regulates bone formation in distraction osteogenesis(DO). Indepth understanding of osteoblast BMP/Smad signaling pathway to stimulate the mechanical response mechanisms
    and the role of molecular biology DO mechanism for the application of exogenous BMP and provide a theoretical basis for gene therapy.
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    Relationship between high temperature requirement A and dental caries caused by <
    LI Jing, LIU Xing-rong
    Inter J Stomatol. 2009, 36 (3):  338-338~340. 
    Abstract ( 1612 )   HTML ( 2 )   PDF(pc) (119KB) ( 1111 )   Save
    Streptococcus mutansS.mutans) is known as a primary pathogen of dental caries, and its exopolysaccharide synthesis, adherence to tooth surface and biofilm formation is important physiological and virulence factor of S.mutans. High temperature requirement A(HtrA) is a periplasmic heat shock protein, which reduces the ability to withstand high temperature, extreme of pH and oxidative stress. This article reviewed the relationship between HtrA and virulence factors of S.mutans.
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    Crosstalk between Wnt and Notch signaling pathways and their relationships with o
    PANG Bao -xing, JIN Xiao -ming
    Inter J Stomatol. 2009, 36 (3):  341-343.  DOI: 10.3969/j.issn.1673-5749.2009.03.028
    Abstract ( 1322 )   HTML ( 3 )   PDF(pc) (118KB) ( 1618 )   Save
    Wnt and Notch signaling pathways have long been regarded as the signaling pathways playing critical roles in the tumorigenesis and progression of various kinds of human cancers. This article reviewed the crosstalk between Wnt and Notch signaling pathways, particularly focusing on their relationship with oral squamous cell carcinoma.
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    Research progress of cyclo-oxygenase-2 selective inhibitor Celecoxib and the inva
    HUO Qiu-ju, LI Wei-zhong
    Inter J Stomatol. 2009, 36 (3):  344-346,350.  DOI: 10.3969/j.issn.1673-5749.2009.03.029
    Abstract ( 1503 )   HTML ( 2 )   PDF(pc) (141KB) ( 711 )   Save
    Cyclo-oxygenase(COX) is the major rate-limiting enzyme for the synthesis of prostaglandins. COX-2, which is the inducible form, involved in inflammation and cancer incidence. Study found, COX-2 was overexpressed in the majority of malignant carcinomas including tongue squamous carcinoma. In addition, the increasing activity of COX-2 can improve the adhesion capacity of cells and the extracellular matrix protein, enhance expression level of matrix etalloprotease, and increase the invasion of tumor cells. Further studing the relationship between the cyclo -oxygenase -2 selective inhibitor and tongue squamous carcinoma invasion is very important for tongue cancer treatment and prognosis.
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    Research progress of finite element analysis on fatigue behavior o f all -ceramic
    HUANG Jue-hui, ZHAO Ke, ZHANG Xin-ping
    Inter J Stomatol. 2009, 36 (3):  347-350.  DOI: 10.3969/j.issn.1673-5749.2009.03.030
    Abstract ( 1335 )   HTML ( 2 )   PDF(pc) (133KB) ( 693 )   Save
    All-ceramic crowns and bridges have been widely used for dental restorations owing to their excellent functionality, aesthetics and biocompatibility. However, the premature clinical failure of all -ceramic crowns and bridges may easily occur when subjected to repetitive occlusal contact loading. In order to provide efficient theoretical instruction for clinical applications, the finite element method can be used to analyze the fatigue behavior, optimize the design of all-ceramic crowns and bridges, and to evaluate the reliability and durability. This paper
    reviewed the recent research progress of fatigue behavior of all -ceramic crowns and bridges by finite element method.
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    Regulation of receptor activator of nuclear factor-κB ligand-receptor activator
    LIU Li, LUO Yun, WANG Min
    Inter J Stomatol. 2009, 36 (3):  351-354.  DOI: 10.3969/j.issn.1673-5749.2009.03.031
    Abstract ( 1506 )   HTML ( 3 )   PDF(pc) (147KB) ( 1017 )   Save
    Receptor activator of nuclear factor-κB ligand(RANKL)-receptor activator of nuclear factor-κB(RANK)and osteoprotegerin(OPG) discovered in the mid 1990s is the key signaling system for the regulation of bone resorption.
    RANKL-RANK signaling regulates osteoclast formation, activation and survival in normal bone modeling and remodeling and increases bone resorption in a variety of pathologic conditions. OPG protects bone from excessive resorption by binding to RANKL and preventing it from binding to RANK. This article reviewed regulation of RANKL-RANK-OPG in bone modeling and remodeling.
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    Clinical research about cracked tooth
    CHEN Yu, LIN Zheng-mei
    Inter J Stomatol. 2009, 36 (3):  355-357,360.  DOI: 10.3969/j.issn.1673-5749.2009.03.032
    Abstract ( 1605 )   HTML ( 33 )   PDF(pc) (135KB) ( 2182 )   Save
    Epidemiological data reveals that as the improving of the oral health, morbidity rate of caries and periodontal diseases has decreased. Tooth fracture becomes a common cause of tooth loss in industrialized countries. Cracks and fractures can be classified as follows due to the extension and tissue involved: craze lines, fractured cusps, cracked teeth, split teeth and vertical root fractures. According to the pulp status and cracked extension, tooth fracture falls into two different types, which are incomplete tooth fracture and complete tooth fracture
    of vital and non-vital tooth. Cracked tooth belongs to the incomplete tooth fracture of tooth with vital pulp. The cracked tooth with symptoms is called cracked tooth syndrome. This review focused on the clinical research about cracked tooth, which was providing thoughtway to diagnosis and therapy of cracked tooth.
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    Research progress on manufacturing factors of the fracture about nickel-titanium
    CHEN Xiao-chun, CHEN Xin-mei
    Inter J Stomatol. 2009, 36 (3):  358-360.  DOI: 10.3969/j.issn.1673-5749.2009.03.033
    Abstract ( 1511 )   HTML ( 5 )   PDF(pc) (109KB) ( 1015 )   Save
    Although the nickel-titanium(Ni-Ti) alloy with super-elastic property is more and more used in endodontics, it has been reported that rotary Ni-Ti instruments are more prone to intracanal fracture compared with stainless steel instruments. These unexpected fractures occur without any visible changes to the instruments which produce a prominence problem creating a major obstacle to normally routine therapy. Many studies showed that the presence of defects on and in the Ni-Ti instruments before used restrict clinical application. In recent years, considerable attempt has been undertaken to improve these condition and produced more flexible and resistant Ni-Ti endodontic instruments, which may minimize the occurrence of fractures. This article reviewed the development of manufacturing methods of Ni-Ti endodontic instrument.
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    The role of methyl mercaptan in the etiology of periodontitis
    MA Qin-rui, HE Yong-hong, WAN Hu-chun
    Inter J Stomatol. 2009, 36 (3):  361-363.  DOI: 10.3969/j.issn.1673-5749.2009.03.034
    Abstract ( 1534 )   HTML ( 3 )   PDF(pc) (110KB) ( 805 )   Save
    Methyl mercaptan is the metabolite of putative periodontal pathogen catalyzed by L-methionine-γ-lyase(METase). It plays an important role in cytoskeletal reorganization through increasing permeability of mucosa, cell migration through inhibiting synthesis and secretion of collagen and extracellular matrix, and in collagen degradation and alveolar bone resorption through immunological activities. Production of methyl mercaptan declines with inhibiting the enzyme activity. The objective of this article was to review the production of methyl mercaptan and the relationship of methyl mercaptan and periodontitis.
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    Research progress of orthopedic treatment on facial bone with implant anchorage i
    CANG Song, BAI Yu-xing, WANG Bang-kang
    Inter J Stomatol. 2009, 36 (3):  364-366.  DOI: 10.3969/j.issn.1673-5749.2009.03.035
    Abstract ( 1504 )   HTML ( 3 )   PDF(pc) (110KB) ( 823 )   Save
    Stable anchorage on orthopedic treatment is very important. Orthodontists routinely use teeth for the application of force to bone to effect skeletal change. Unfortunately, this indirect application of force limits the potential for orthopedic change and often causes undesirable tooth movement and root resorption. Hence, using of skeletal anchorage to apply force directly to bone would be more desirable. Recently, dental implants are used foranchorage on orthopedic treatment in orthodontics because of their good biocompatibility. Scholars do a lot of substructure and clinic research on orthopedic treatment in orthodontics. In the article, we reviewed orthopedic treatment on facial bone with implant anchorage in orthodontics.
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    Research progress of root filling material removal by modern methods of root trea
    XIA Qian, GUO Bin
    Inter J Stomatol. 2009, 36 (3):  367-369,373.  DOI: 10.3969/j.issn.1673-5749.2009.03.036
    Abstract ( 1422 )   HTML ( 7 )   PDF(pc) (135KB) ( 1175 )   Save
    The re-treatment of failed endodontic treatment includes complete removal of the root filling material, shaping root canals, disinfection with medicaments and ultimately filling. Removing as much filling material as possible is very essential for success. However, one of the greatest difficulties faced by re-treatment is achieving complete removal of filling materials. With the development of modern instruments and techniques, stainless steel hand files, engine-driven rotary files, solvents, heat-carrying and ultrasonic instruments are helpful devices aiming to remove completely the root filling material. This review was undertaken of the current literature on modern methods of filling material removal.
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    Research advance of the jaw bone density
    KANG Ning, GONG Ping
    Inter J Stomatol. 2009, 36 (3):  370-373.  DOI: 10.3969/j.issn.1673-5749.2009.03.037
    Abstract ( 1362 )   HTML ( 2 )   PDF(pc) (136KB) ( 884 )   Save
    The measurement of the jaw bone density is vital to the diagnosis and treatment of the periodontal disease and oral implant prosthesis, and it is one of the major topics in oral medicine for a long time. With the development of modern measurement instrument, widely used of non-invasive and high accuracy measurement technology of bone density, great progress has been made in the jaw bone density measurement recently. The ionizing radiation measurement is the most popular technology used in domestic and international characterized by low cost and good performance in measurement accuracy, while the non-ionizing radiation measurement is more safer and
    environment-protected by avoiding the dangers of radiation. In this paper, the progress of jaw bone density measurement was reviewed in both the ionizing radiation and non-ionizing radiation measurement fields.
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    The clinical application of hard palatal mucoperiosteum flap
    YAN Guang-tang, LIANG Shang-zheng
    Inter J Stomatol. 2009, 36 (3):  374-376.  DOI: 10.3969/j.issn.1673-5749.2009.03.038
    Abstract ( 1584 )   HTML ( 2 )   PDF(pc) (99KB) ( 1257 )   Save
    Hard palatal mucoperiosteum flap has merits of manufacturing easily and high survival rate. It can be manufactured pedicle flap with blood vessel, random flap, free flap to repair the defects of soft tissues of oral maxillofacial region, especially to the defects of smaller area on oral soft tissues. This article was an overview of clinical application of hard palatal mucoperiosteum flap, proposing to provide choices to clinical surgical works.

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