Int J Stomatol

Inter J Stomatol ›› 2009, Vol. 36 ›› Issue (3): 319-322.doi: 10.3969/j.issn.1673-5749.2009.03.021

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Roles of 4-1BB and 4-1BB ligand in oral cancer immunotherapy

SUN Shun-tao, YANG Hong-yu   

  1. Dept. of Oral and Maxillofacial Surgery, Shenzhen Hospital, Peking University, Sh
  • Received:2008-12-31 Revised:2009-02-13 Online:2009-05-20 Published:2009-05-20
  • Contact: YANG Hong-yu

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Abstract: 4-1BB and 4-1BB ligand（4-1BBL） are members of the tumor necrosis factor/tumor necrosis factor receptor family, which are expressed on T cells and antigen-presenting cells （APC） respectively. In recent study, therapies utilizing the 4-1BB/4-1BBL signaling pathway have been shown to have antitumor effects in a number of model systems. In this report, we focus solely on the role of 4-1BB and its receptor 4-1BBL in costimulation and discuss its potential as a target for the immunotherapy of oral cancer.

Key words: 4-1BB/4-1BB ligand, costimulatory molecules, immunotherapy


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