Int J Stomatol

Int J Stomatol ›› 2025, Vol. 52 ›› Issue (5): 594-605.doi: 10.7518/gjkq.2025061

• Cariology and Endodontics • Previous Articles     Next Articles

Research progress on scaffold-based prevascularization technique for dental pulp tissue

Tian Li1,2(),Lijie Li1,2()   

  1. 1.Dept. of Stomatology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China
    2.School of Stomatology, Inner Mongolia Medical University, Hohhot 010059, China
  • Received:2024-08-06 Revised:2024-10-07 Online:2025-09-01 Published:2025-08-27
  • Contact: Lijie Li E-mail:1785708725@qq.com;lilijie2007148@126.com

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Abstract:

In young permanent teeth with pulp necrosis, the current clinical approach for pulp revascularization does not effectively reconstruct functional pulp-like tissue and may lead to root canal calcification. Consequently, regenerative endodontic treatment has garnered widespread attention from scholars. The primary aim of dental pulp tissue regeneration is to restore the activity and functionality of autologous dental pulp tissue, with the rapid formation of a functional vascular network taken as a critical success factor. However, the root canal and medullary cavity present relatively narrow, airtight, ischemic, and hypoxic environments, which impedes the growth of the functional vascular network from the root canal to the medullary cavity. This challenge has been addressed by researchers who proposed prevascularization technique, which involves the formation of a functional vascular network within engineered tissue to ensure an adequate blood supply to the construct. This vascular network can anastomose with the host vasculature, ultimately facilitating the regeneration of vascularized dental pulp tissue. This article reviews potential cell types, growth factors, and scaffold sources pertinent to scaffold-based prevascularization technology. Three dimension (3D) bioprinting technology related to prevascula-rization is discussed, and a theoretical foundation for advancements in regenerative medicine is provided.

Key words: pulp tissue engineering, pulp tissue regeneration, prevascularization technique, scaffold, three dimension bioprinting

CLC Number: 

  • R781

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