Int J Stomatol

Int J Stomatol ›› 2025, Vol. 52 ›› Issue (1): 123-132.doi: 10.7518/gjkq.2025013

• Reviews • Previous Articles    

Smart responsive hydrogels and their application in controlled drug release

Qipei Luo(),Xinchun Zhang()   

  1. Dept. of Prosthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University & Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2024-03-19 Revised:2024-09-15 Online:2025-01-01 Published:2025-01-11
  • Contact: Xinchun Zhang E-mail:luoqp3@mail2.sysu.edu.cn;zhxinch@mail.sysu.edu.cn
  • Supported by:
    Natural Science Foundation of Guangdong Province(2022A1515012485)

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Abstract:

Hydrogels are polymeric materials with advantageous properties of facile functionalization and drug encapsulation, rendering them applicable in drug delivery. Compared with regular hydrogels, smart responsive hydrogels are superior drug delivery systems due to their ability to intelligently respond to stimuli and avoid burst drug release in the early stage. These hydrogels can effectively react to microenvironmental alterations in disease conditions or external stimuli, hence enabling precise and timely controlled drug release. In this work, the unique response mechanism of hydrogels responsive to pH, reactive oxygen species, chemical, temperature, magnetic, light and ultrasound and their innovative application in the treatment of various diseases are reviewed. The findings present the frontier progress in this field and point out the development direction of future research.

Key words: hydrogels, smart responsive hydrogels, drug delivery, controlled drug release

CLC Number: 

  • R452

TrendMD: 

Fig 1

The response schematic diagram of pH responsive hydrogels"

Fig 2

The response schematic diagram of ROS responsive hydrogels"

Fig 3

The response schematic diagram of chemical responsive hydrogels"

Fig 4

The response schematic diagram of thermo-responsive hydrogels"

Fig 5

The response schematic diagram of magnetic responsive hydrogels"

Fig 6

The response schematic diagram of photoresponsive hydrogels"

Fig 7

The response schematic diagram of ultrasound responsive hydrogels"

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