Int J Stomatol

Int J Stomatol ›› 2024, Vol. 51 ›› Issue (5): 532-537.doi: 10.7518/gjkq.2024075

• Oral mucosal disease • Previous Articles     Next Articles

Retrospective study on the pathological and clinical biological behavior of 133 cases of oral squamous cell carcinomas originated from oral submucous fibrosis

Guanjun Chen1,2(),Xiao Fu1,2,Haiyu Xian2,Shouda Su1,2,Qitao Wen2,Wei Deng1,2,Shigeng Lin2,Tao Wang1,2()   

  1. 1.School of Stomatology, Hainan Medical University, Haikou 571199, China
    2.Dept. of Stomatology, Hainan General Hospital, Haikou 570311, China
  • Received:2024-03-25 Revised:2024-05-06 Online:2024-09-01 Published:2024-09-14
  • Contact: Tao Wang E-mail:310633109@qq.com;1293379391@qq.com
  • Supported by:
    National Natural Science Foundation of China(81960199);Hainan Province Science and Technology Special Fund(ZDYF2021SHFZ114)

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Abstract:

Objective　This study aimed to analyze the clinical characteristics as well as the pathological and biological behavior of oral squamous cell carcinoma (OSCC) originated from oral submucous fibrosis (OSF) caused by the habit of chewing fresh betel nut. Methods　A total of 247 patients with OSCC who underwent surgical treatment were retrospectively analyzed, including 133 cases of OSCC with OSF caused by the habit of chewing fresh betel nut (OSCC-OSF group) and 114 cases of OSCC without OSF (OSCC group). Clinical data and pathological results of the patients were collected, and the age, sex, lesion location, clinical stage, pathological grade, lymph node metastasis rate, and recurrence rate of the patients were analyzed. SPSS 26.0 was used for data analysis, and differences at P<0.05 were consi-dered statistically significant. Results　The results of this study indicated that the average age of the OSCC-OSF group [(50.68±11.54) years old] was lower than that of the OSCC group [(57.90±12.85) years old]. In addition, the male-to-female ratio in the OSCC-OSF group was higher than that in the OSCC group (6.82∶1 vs 2.16∶1), and the difference was statistically significant (P<0.05). Although OSF canceration has a significant effect on the pathological differentiation of OSCC (P<0.05), the pathological differentiation of the OSCC-OSF group was remarkable, and the pathological differentiation of the OSCC group was poor. The recurrence rate of the OSCC-OSF group (19.1%) was lower than that of the OSCC group (31.5%). The 5-year survival rate of the OSCC-OSF group (85.5%) was higher than that of the OSCC group (74.8%), and the difference was statistically significant (P<0.05). However, OSF has no significant effect on the lymph node metastasis rate and clinical stages of OSCC (P>0.05). Conclusion　The OSF patients with OSCC who also have the habit of chewing fresh betel nut were mainly male. The tumors often occurred in the tongue, cheeks, and lips, and the degree of tumor differentiation and prognosis was good.

Key words: oral submucous fibrosis, canceration, pathological differentiation, lymphatic metastasis, prognosis

CLC Number: 

  • R739.8

TrendMD: 

Tab 1

Clinicopathological features of OSCC-OSF group and OSCC without OSF group"

变量OSF癌变组非OSF癌变组F/χ2/Z值P值
年龄/岁50.68±11.5457.90±12.851.2470.000
性别/ n（%）12.8690.000
男116（87.2）78（68.4）
女17（12.8）36（31.6）
病理分化程度/ n（%）-2.6470.008
高分化113（85.0）a81（71.1）b
中分化16（12.0）a26（22.8）b
低分化4（3.0）a7（6.1）a
淋巴结转移/ n（%）0.5040.478
是38（28.6）28（24.6）
否95（71.4）86（75.4）
临床分期/ n（%）-0.4440.657
T121（15.8）21（18.4）
T281（60.9）69（60.5）
T326（19.5）15（13.2）
T45（3.8）9（7.9）
预后*/ n（%）4.9930.025
复发25（19.1）35（31.5）
无复发106（80.9）76（68.5）
5年生存率*/ n（%）4.4130.036
死亡19（14.5）28（25.2）
存活112（85.5）83（74.8）

Tab 2

Lymph node metastasis in 247 patients with OSCC n（%）"

临床分期淋巴结转移χ2值P值
是（n=66）否（n=181）
临床早期合计 （T1+T2）44（23.0）147（77.0）5.8390.016
临床晚期合计 （T3+T4）22（39.3）34（60.7）
临床早期1.6510.199
OSF癌变组27（26.7）74（73.3）
非OSF癌变组17（18.9）73（81.1）
临床晚期0.7550.385
OSF癌变组11（34.4）21（65.6）
非OSF癌变组11（45.8）13（54.2）

Tab 3

Tumor location in 247 patients with OSCC"

分组部位χ2值P值
舌颊牙龈口咽腭口底唇
OSF癌变组/ n（%）58（43.6）a31（23.3）a12（9.0）a11（8.3）a2（1.5）a7（5.3）a12（9.0）a26.0620.000
非OSF癌变组/n（%）61（53.5）a10（8.8）b11（9.6）a12（10.5）a12（10.5）b7（6.1）a1（1.0）b
例数合计119412323141413
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