Int J Stomatol

Inter J Stomatol ›› 2015, Vol. 42 ›› Issue (5): 597-599.doi: 10.7518/gjkq.2015.05.027

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The pathogenesis, clinical manifestations, and treatment of Peutz-Jeghers syndrome

Tang Yanjie1, Shi Jing2, Wu Yunxia3.   

  1. 1. College of Stomatology, Shanxi Medical University, Taiyuan 030001, China; 2. Dept. of Oral Medicine, Shanxi Provincial People’s Hospital, Taiyuan 030012, China; 3. Dept. of Oral Comprehensive, The First Hospital, Shanxi Medical University, Taiyuan 030001, China
  • Received:2014-08-12 Revised:2015-03-31 Online:2015-09-01 Published:2015-09-01

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Abstract:

Peutz-Jeghers syndrome(PJS) is autosomal dominant genetic disease. Mucosa pigmentation and gastrointestinal polyps are the main clinical manifestations in PJS patients. The etiology is complex and unclear and may be closely related with the liver kinase B1, fragile histidine triad, and p53 genes. PJS gastrointestinal malignant polyps may form. In addition, PJS can also be associated with other tumors. Mucocutaneous melanin spots are unique characteristics of PJS in patients. Patients often receive treatment in stomatology departments, and treatment methods are surgery, freezing, dermabrasion, power dry, and laser treatments. Gastrointestinal polyps are removed by surgery. PJS patients should be treated as soon as to prevent cancer.

Key words: Peutz-Jeghers syndrome, pigmentation, canceration, cancer susceptibility, therapy


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