Int J Stomatol

Int J Stomatol ›› 2019, Vol. 46 ›› Issue (3): 316-319.doi: 10.7518/gjkq.2019021

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Research progress on osteoprotegerin in oral science

Xin Gao,Rongsheng Zeng()   

  1. Dept. of Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2018-06-06 Revised:2018-12-13 Online:2019-05-01 Published:2019-06-05
  • Contact: Rongsheng Zeng E-mail:rszeng@yahoo.ca
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81070818)

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Abstract:

Known as a new member of the tumour necrosis factor receptor superfamily, osteoprotegerin (OPG) inhibits osteoclastogenesis and osteoclast activation through the receptor-activator of nuclear factor-κB ligand (RANKL)/receptor-activator of nuclear factor-κB (RANK)/OPG signal pathway. Additionally, osteoclasts are directly involved in the regulation of bone metabolism and play a major role in alveolar bone reconstruction and root resorption. This review focused on the implications of osteoprotegerin during orthodontic tooth movement, periodontitis, osteointegration, tooth eruption and other oral aspects.

Key words: osteoprotegerin, osteoclast, alveolar bone reconstruction, root resorption, osteointegration

CLC Number: 

  • Q257

TrendMD: 
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