Inter J Stomatol ›› 2017, Vol. 44 ›› Issue (2): 183-188.doi: 10.7518/gjkq.2017.02.014

• Original Articles • Previous Articles     Next Articles

Effect of insulin on bone metabolism around implant in diabetic rats

Wu Yingying, Gong Ping.   

  1. State Key Laboratory of Oral Diseases, Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2016-06-29 Online:2017-03-01 Published:2017-03-01
  • Supported by:
    This study was supported by the General Program of National Natural Science Foundation of China(81170995) and the Young Scientists Fund of National Natural Science Foundation of China(81400543).

Abstract: Objective We studied the bone metabolism and implant bone contact in diabetic subjects treated with insulin. Methods Diabetic rat models were established and implanted with titanium implants and insulin treatment. The osteoblasts were cultured in high glucose amounts and treated with insulin. Results Diabetes decreased bone formation and mineralization around the rat implants, which were improved by insulin treatment. However, the implant-bone contact in insulin-treated diabetic rats remained less than those in normal rats. Moreover, insulin treatment increased the insulin receptor expression in osteoblasts that have been cultured in high glucose amounts. Conclusion Our Results indicated the role of insulin in osteoblast function in diabetic rats probably through insulin signaling; moreover, insulin mediates bone metabolism and improves bone formation and mineralization in hyperglycemic conditions.

Key words: diabetes mellitus, implant, insulin, bone metabolism

CLC Number: 

  • R783.4

TrendMD: 
5 5 参考文献
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