Int J Stomatol

Inter J Stomatol ›› 2009, Vol. 36 ›› Issue (3): 351-354.doi: 10.3969/j.issn.1673-5749.2009.03.031

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Regulation of receptor activator of nuclear factor-κB ligand-receptor activator

LIU Li, LUO Yun, WANG Min   

  1. Dept. of Prosthodontics, West China College of Stomatology, Sichuan University, C
  • Received:2008-11-10 Revised:2008-12-29 Online:2009-05-20 Published:2009-05-20
  • Contact: LUO Yun

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Abstract: Receptor activator of nuclear factor-κB ligand（RANKL）-receptor activator of nuclear factor-κB（RANK）and osteoprotegerin（OPG） discovered in the mid 1990s is the key signaling system for the regulation of bone resorption.
RANKL-RANK signaling regulates osteoclast formation, activation and survival in normal bone modeling and remodeling and increases bone resorption in a variety of pathologic conditions. OPG protects bone from excessive resorption by binding to RANKL and preventing it from binding to RANK. This article reviewed regulation of RANKL-RANK-OPG in bone modeling and remodeling.

Key words: bone resorption, osteoclast, receptor activator of nuclear factor-κB ligand, receptor activator of nuclear factor-κB, osteoprotegerin


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