Int J Stomatol

Inter J Stomatol ›› 2010, Vol. 37 ›› Issue (02): 163-163～165.doi: 10.3969/j.issn.1673-5749.2010.02.011

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Research progress of hydroxyapatite binding proteins and peptides

WEI Wei, LIU Yan, MAO Jing, ZHOU Bin   

  1. Center of Stomatology, The Affiliated Tongji Hospital of Tongji Medical College,
  • Received:2009-06-03 Revised:2009-09-28 Online:2010-03-20 Published:2010-03-20
  • Contact: MAO Jing

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Abstract: There are many natural protein able to bind to hydroxyapatite crystal. Some of these macromolecules recognize the special structure of the crystal surface and play an important role in biomineralization. However, the exact mechanism of the interfacial recognition and how macromolecules govern hard-tissue formation are still unknown. Recently, combinations of biomimetics and molecular biology have been developed to understand the recognition between macromolecules and inorganic surface, which might stimulate the research of new biomaterials. Here we review recent studies that have revealed the recognition at the protein-hydroxyapatite or peptide-hydroxyapatite interface.

Key words: hydroxyapatite, binding protein, peptide, phage surface display

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