Int J Stomatol

Inter J Stomatol ›› 2016, Vol. 43 ›› Issue (3): 314-317.doi: 10.7518/gjkq.2016.03.014

Previous Articles     Next Articles

Research progress on xerostomia of Sjögren syndrome

Wang Lu, Li Xia   

  1. Dept. of Conservative Dentistry and Endodontics, The Affiliated Stomatological Hospital of Shanxi Medical University, Taiyuan 030001, China) This study was supported by the Shanxi Province Science and Technology Research Program(20150313010-3).
  • Received:2015-05-06 Revised:2015-11-30 Online:2016-05-01 Published:2016-05-01

RichHTML

3

PDF (PC)

504

Abstract: Sj?gren syndrome(SS) is a chronic autoimmune disease that occurs because of the impairment of the exocrine gland function. Xerostomia is the first sign of SS, and this symptom indicates the beginning of lesions. As the pathogenesis remains unclear, no complete treatment exists. Recently, the functions of aquaporins, capsaicin receptor, and vasoactive intestinal peptide in the pathogenesis of SS xerostomia have gradually received increasing attention. Therefore, this paper reviews the functions and treatment of these factors in the pathogenesis of SS xerostomia.

Key words: Sj?gren syndrome, xerostomia, aquaporin, transient receptor potential vanillic, vasoactive intestinal peptide, Sj?gren syndrome, xerostomia, aquaporin, transient receptor potential vanillic, vasoactive intestinal peptide

CLC Number: 

  • R 781.7

TrendMD: 
[1] 张洪义, 胡秀芹, 金仲品. 原发性干燥综合症临床首发症状及实验室检查100例分析[J]. 中国实用医药, 2010, 5(23):10-11.
Zhang HY, Hu XQ, Jin ZP. Clinical initialdose happen symptom and laboratory examination of 100 cases analyse of PSS[J]. Chin Pract Med, 2010, 5(23):10-11.
[2] Delporte C. Aquaporins in salivary glands and pancreas Delporte C. Aquaporins in salivary glands and pancreas[J]. Biochim Biophys Acta, 2014, 1840(5):1524-1532.
[3] 罗慧臣, 李抨, 肖卫国. M3R与AQP5在干燥综合征患者唇腺中的表达与意义[J]. 中国免疫学杂志, 2011, 27(1):79-81, 87.
Luo HC, Li P, Xiao WG. Expression of muscarinic receptor 3 and aquaporin 5 in patients with Sj?gren’s syndrome in the labial glands[J]. Chin J Immunol, 2011, 27(1):79-81, 87.
[4] Ding C, Cong X, Zhang Y, et al. Hypersensitive mAChRs are involved in the epiphora of transplanted glands[J]. J Dent Res, 2014, 93(3):306-312.
[5] 刘燕, 钱先. AQP5在干燥综合征发病机制中作用研究进展[J]. 辽宁中医药大学学报, 2014, 16(1):85-87.
Liu Y, Qian X. Research progress of AQP5 in pathogenesis of Sj?gren’s syndrome[J]. J Liaoning Univ Tradit Chin Med, 2014, 16(1):85-87.
[6] Lee BH, Gauna AE, Perez G, et al. Autoantibodies against muscarinic type 3 receptor in Sj?gren’s syndrome inhibit aquaporin 5 trafficking[J]. PLoS One, 2013, 8(1):e53113.
[7] Wang D, Yuan Z, Inoue N, et al. Abnormal subcellular localization of AQP5 and downregulated AQP5 protein in parotid glands of streptozotocin-induced diabetic rats[J]. Biochim Biophys Acta, 2011, 1810(5):543-554.
[8] 王頔, 秦臻, 周党侠, 等. M3受体激动剂诱导大鼠腮腺细胞内AQP5和脂质筏的核转移[J]. 基础医学与临床, 2015, 35(2):237-239.
Wang D, Qin Z, Zhou DX, et al. M3 receptor agonist induced rat AQP5 and parotid gland cell nuclear transfer of lipid rafts[J]. Bas Clin Med, 2015, 35(2):237-239.
[9] Nakamura M, Saga T, Watanabe K, et al. An immunohistochemistry-based study on aquaporin(AQP)-1, 3, 4, 5 and 8 in the parotid glands, submandibular glands and sublingual glands of Sj?gren’s syndrome mouse models chronically administered cevimeline[J]. Kurume Med J, 2013, 60(1):7-19.
[10] Gresz V, Horvath A, Gera I, et al. Immunolocalization of AQP5 in resting and stimulated normal labial glands and in Sj?gren’s syndrome[J]. Oral Dis, 2015, 21(1):e114-e120.
[11] 王松灵, 颜兴. 基因转导及组织工程重建涎腺功能[J]. 口腔颌面外科杂志, 2008, 18(3):153-157.
Wang SL, Yan X. Reconstruction of salivary gland function with gene transfer or tissue engineering[J]. J Oral Maxillofac Surg, 2008, 18(3):153-157.
[12] 李魁君, 李春刚, 刘兴君. 辣椒素受体(TRPV1)的生物学作用及其作为药物靶点的研究进展[J]. 沈阳药科大学学报, 2011, 28(11):917-927.
Liu KJ, Li CG, Liu XJ. Progress on the capsaicin receptor-TRPV1: biological actions and as a therapeutic target for novel drugs[J]. J Shenyang Pharmaceut Univ, 2011, 28(11):917-927.
[13] Zhang Y, Cong X, Shi L, et al. Activation of transient receptor potential vanilloid subtype 1 increases secretion of the hypofunctional, transplanted submandibular gland[J]. Am J Physiol Gastrointest Liver Physiol, 2010, 299(1):G54-G62.
[14] Sobhan U, Sato M, Shinomiya T, et al. Immunolocalization and distribution of functional temperaturesensitive TRP channels in salivary glands[J]. Cell Tissue Res, 2013, 354(2):507-519.
[15] 丛馨, 张艳, 俞光岩, 等. 激活辣椒素受体是调控下颌下腺分泌的新途径[J]. 北京大学学报: 医学版, 2015, 47(1):8-12.
Cong X, Zhang Y, Yu GY, et al. Activation of transient receptor potential vanilloid subtype 1 serves as a novel path-way to modulate secretion in submandibular gland[J]. J Pek Univ: Hea Sci, 2015, 47(1):8-12.
[16] Ding QW, Zhang Y, Wang Y, et al. Functional vanilloid receptor-1 in human submandibular glands [J]. J Dent Res, 2010, 89(7):711-716.
[17] Hasegawa T, Azlina A, Javkhlan P, et al. Novel phosphorylation of aquaporin-5 at its threonine 259 through cAMP signaling in salivary gland cells[J]. Am J Physiol, Cell Physiol, 2011, 301(3):C667-C678.
[18] Choi S, Shin YH, Namkoong E, et al. TRPV1 in salivary gland epithelial cells is not involved in salivary secretion via transcellular pathway[J]. Korean J Physiol Pharmacol, 2014, 18(6):525-530.
[19] Cong X, Zhang Y, Yang NY, et al. Occludin is required for TRPV1-modulated paracellular permeability in the submandibular gland[J]. J Cell Sci, 2013, 126(Pt 5):1109-1121.
[20] Cong X, Zhang Y, Shi L, et al. Activation of transient receptor potential vanilloid subtype 1 increases expression and permeability of tight junction in normal and hyposecretory submandibular gland[J]. Lab Invest, 2012, 92(5):753-768.
[21] 王洋, 张雷, 俞光岩. 辣椒素对移植颌下腺“休眠期”腺体分泌功能的影响[J]. 中华口腔医学杂志, 2007, 42(3):161-164.
Wang Y, Zhang L, Yu GY. The effect of capsaicin on the secretion of the transferred submandibular gland in “latent period”[J]. Chin J Stomatol, 2007, 42(3):161-164.
[22] Hauk V, Calafat M, Larocca L, et al. Vasoactive intestinal peptide/vasoactive intestinal peptide receptor relative expression in salivary glands as one endogenous modulator of acinar cell apoptosis in a murine model of Sj?gren’s syndrome[J]. Clin Exp Immunol, 2011, 166(3):309-316.
[23] Jimeno R, Gomariz RP, Gutiérrez-Ca?as I, et al. New insights into the role of VIP on the ratio of Tcellsubsets during the development of autoim-mune diabetes[J]. Immunol Cell Biol, 2010, 88(7):734-745.
[24] 林传权, 陈玉龙, 李茹柳, 等. 利血平对大鼠唾液蛋白分泌的影响[J]. 世界华人消化杂志, 2009, 17(17):1702-1706.
Lin CQ, Chen YL, Li RL, et al. Effect of reserpine on the secretion of salivary protein in rats[J]. Wor Chin J Digestol, 2009, 17(17):1702-1706.
[25] Parvin MN, Kurabuchi S, Murdiastuti K, et al. Subcellular redistribution of AQP5 by vasoactive intestinal polypeptide in the Brunner’s gland of the rat duodenum[J]. Am J Physiol Gastrointest Liver Physiol, 2005, 288(6):G1283-G1291.
（本文采编 王晴）
[1] Chen Xiaoli,Zhang Fan,Liu Chengcheng. Application progress on photobiomodulation in the prevention and treatment of oral complications after radiothe-rapy [J]. Int J Stomatol, 2022, 49(6): 707-716.
[2] Chen Dong,Yang Zheng,Jiang Li. Research progress on the evaluation and management of radiation-induced xerostomia [J]. Int J Stomatol, 2019, 46(6): 711-717.
[3] Liu Xin, Zhou Jinglin. Treatment progress of chinese and western medicine on xerostomia [J]. Inter J Stomatol, 2014, 41(5): 571-574.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[7] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[9] . [J]. Foreign Med Sci: Stomatol, 2004, 31(02): 126 -128 .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .