Int J Stomatol ›› 2024, Vol. 51 ›› Issue (3): 278-287.doi: 10.7518/gjkq.2024041

• Oral tissue regeneration • Previous Articles     Next Articles

Research progress on mechanism and drug treatment of orofacial muscle regeneration and fibrosis

Jinfeng Dou(),Xu Cheng,Bing Shi()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2023-09-25 Revised:2024-01-23 Online:2024-05-01 Published:2024-05-06
  • Contact: Bing Shi;
  • Supported by:
    National Natural Science Foundation of China(81974147)


Patients with congenital maxillofacial deformities such as cleft lip and palate are often characterized by the abnormal structure and function of the orofacial muscles. After facial plastic surgeries, orofacial muscles usually exhibit the characteristics of impaired myogenesis and excessive fibrosis, which greatly limits the recovery of orofacial function. Orofacial muscles are skeletal muscle subsets with unique evolutionary and developmental characteristics. The occurrence of orofacial muscle fibrosis is related to its unique embryonic development source and inherent regeneration characteristics. Muscle satellite cell and fibroadipogenic progenitors are the two main cell types in the skeletal muscle tissue that are responsible for the myogenic process and fibrogenic process, respectively. Myogenesis-fibrogenesis imbalance is an important factor in orofacial muscle fibrosis. A variety of antifibrosis drugs are expected to improve skeletal muscle fibrosis effectively. This review focuses on the specificity of orofacial muscle development and regeneration, the cytological basis of orofacial muscle fibrosis, and the treatment of orofacial muscle fibrosis to clarify the unique mechanism of orofacial muscle regeneration and to develop the precise treatment for orofacial muscle regeneration.

Key words: orofacial muscle regeneration and fibrosis, congenital maxillofacial deformity, satellite cells, fibroadi-pogenic progenitors

CLC Number: 

  • R782.2


Fig 1

Mechanism and drug treatment of orofacial muscle regeneration and fibrosis"

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