Int J Stomatol

Int J Stomatol ›› 2021, Vol. 48 ›› Issue (4): 385-390.doi: 10.7518/gjkq.2021079

• Periodontitis • Previous Articles     Next Articles

Research progress on the relationship among oxidative stress, mitochondrial quality control, and periodontitis

Ding Xu1(),Li Xin1,Li Yan1,Xia Boyuan1,Yu Weixian2,3()   

  1. 1. Dept. of Periodontology, Hospital of Stomatology, Jilin University, Changchun 130021, China
    2. Dept. of Geriatric Stomatology, Hospital of Stomatology, Jilin University, Changchun 130021, China
    3. Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China
  • Received:2020-12-25 Revised:2021-03-28 Online:2021-07-01 Published:2021-06-30
  • Contact: Weixian Yu E-mail:1115087326@qq.com;yu-wei-xian@163.com
  • Supported by:
    International Cooperation Project of Science and Technology Development Plan of Science and Technology Department of Jilin Province(20180414053-GH);Natural Science Foundation of Science and Technology Department of Jilin Province(20190201058JC);Science and Technology Project of Finance Department of Jilin Pro-vince(JCSZ2019378-1)

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Abstract:

Periodontitis is a chronic inflammation of the periodontal supporting tissue caused by plaque microorga-nisms. In recent years, scholars have paid close attention to the relationship between mitochondrial quality control and periodontitis. Mitochondrial quality control includes mitochondrial biogenesis, kinetics, and autophagy. Any part of the disorder will lead to mitochondrial dysfunction and then induce the occurrence of related diseases. Some scholars have pointed out that oxidative stress can lead to an imbalance in mitochondrial quality control, which plays a key role in the development of periodontitis. This article reviews the research progress of mitochondrial dysfunction caused by oxidative stress, peroxisome-proliferator-activated receptor-gamma co-activator 1α, nuclear respiratory factor 1/2, mitofusin 1/2, dynamin related protein 1, PTEN-induced putative kinase 1 and other proteins in periodontitis. It aims to provide new ideas for the prevention and treatment of periodontitis.

Key words: mitochondria, oxidative stress, perio-dontitis

CLC Number: 

  • R781.4

TrendMD: 
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