Int J Stomatol

Inter J Stomatol ›› 2012, Vol. 39 ›› Issue (4): 479-481.doi: 10.3969/j.issn.1673-5749.2012.04.017

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Research progress on mitochondrial DNA damage repair in tumor

Li Hejia1, Zhu Yang2, Li Dechao2.   

  1. 1. Dept. of Prosthodontics, The Affiliated Stomatological Hospital of Jiamusi University, Jiamusi 154004, China; 2. Dept. of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Jiamusi University, Jiamusi 154004, China
  • Received:2011-09-21 Revised:2012-04-25 Online:2012-07-01 Published:2012-07-01

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Abstract:

Mitochondria are organelles in mammalian cells, with the only genetic material outside the nucleus mitochondrial DNA（mtDNA）. It supported and participated in many important cellular functions. MtDNA vulnerabled to a variety of factors and cause damage because of special structures and advancement of genetics. When mtDNA damage happened, some mtDNA repair factors, such as: Mitochondrial transcription factor A, mtDNA polymerase- γ, 8-oxoguanine DNA glycosylase enzymes take part in the damage repairing. The entire repair process were regulated by related factors.

Key words: mitochondria, tumor, mitochondrial transcription factor A, mitochondrial DNA polymerase, 8- oxoguanine DNA glycosylase


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