Int J Stomatol

Inter J Stomatol ›› 2013, Vol. 40 ›› Issue (4): 547-549.doi: 10.7518/gjkq.2013.04.039

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Research progress on regulation of octamer -binding transcription factor 4 in stress response

Huang Rong, Wei Xi.   

  1. Dept. of Conservative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2012-08-01 Revised:2013-04-18 Online:2013-07-01 Published:2013-07-01

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Abstract:

Octamer-binding transcription factor 4（Oct4） is the key regulator involved in regulating pluripotency and self-renewal maintenance of embryonic stem cells. Recently, its function diversity has come into focus. Oct4 gene transcription variants, Oct4 gene splicing variants and the role of Oct4 gene in regulating cell stress and dental pulp cells are reviewed in this paper.

Key words: transcription factor, octamer-binding transcription factor 4, stress response, pulptitis


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