Int J Stomatol

Inter J Stomatol ›› 2013, Vol. 40 ›› Issue (4): 537-539.doi: 10.7518/gjkq.2013.04.036

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Kallikrein 4 and amelogenesis imperfecta

Wang Guangping1，2, Li Mingxia1, Liu Jianguo2.   

  1. 1. Dept. of Orthodontics, The Affiliated Stomatological Hospital of Luzhou Medical College, Luzhou 646000, China; 2. Dept. of Oral Medicine, The Affiliated Stomatological Hospital of Zunyi Medical College, Zunyi 563003, China
  • Received:2012-08-20 Revised:2013-04-19 Online:2013-07-01 Published:2013-07-01

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Abstract:

Kallikrein 4（KLK4） is a protease expressed during the transition and maturation stages of dental enamel formation. KLK4 can degrade enamel proteins, reduce enamel proteins combination to hydroxyapatite, and promote the enamel crystals growth and mineralization. KLK4 mutations or defects cause hypomaturation amelogenesis imperfecta. This article reviewed the structure, expression, functions, regulatory factors of KLK4 and its effect on amelogenesis imperfecta.

Key words: kallikrein 4, protein, hydrolysis, amelogenesis imperfecta


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