国际口腔医学杂志

国际口腔医学杂志 ›› 2026, Vol. 53 ›› Issue (3): 433-440.doi: 10.7518/gjkq.2026104

• 综述 • 上一篇    

泛凋亡在口腔疾病中的研究进展

朱玄德(),陈冠辉()   

  1. 中山大学附属第七医院口腔科 深圳 518107
  • 收稿日期:2025-01-23 修回日期:2025-08-08 出版日期:2026-05-01 发布日期:2026-04-24
  • 通讯作者: 陈冠辉
  • 作者简介:朱玄德，硕士，Email：zhuxd25@mail2.sysu.edu.cn
  • 基金资助:
    国家自然科学基金(82303794)

Research progress of PANoptosis in oral diseases

Xuande Zhu(),Guanhui Chen()   

  1. Dept. of Stomatology, the Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China
  • Received:2025-01-23 Revised:2025-08-08 Online:2026-05-01 Published:2026-04-24
  • Contact: Guanhui Chen
  • Supported by:
    National Natural Science Foundation of China(82303794)

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摘要：

细胞程序性死亡是维持宿主免疫和内环境稳态的一种重要机制，对于病原体和宿主间的平衡至关重要。泛凋亡是近年来新提出的一种细胞死亡方式，主要由泛凋亡复合体调控，同时具有凋亡、焦亡、坏死性凋亡的特征。目前越来越多的研究聚焦于泛凋亡参与口腔疾病的机制，本文将泛凋亡的定义、特征、调控机制及其与口腔疾病的潜在关系作一综述，旨在为口腔疾病的检测、预防和治疗提供可能的解决思路。

关键词: 程序性细胞死亡, 泛凋亡, 泛凋亡复合体, 口腔疾病

Abstract:

Programmed cell death (PCD) serves as a crucial mechanism for maintaining host innate immunity, homeostasis, and the balance between pathogens and the host. PANoptosis is a novel form of programmed cell death that is primarily regulated by the PANoptosome complex and concurrently exhibits the features of apoptosis, pyroptosis, and necroptosis. Oral diseases, which significantly impact the quality of life and general health of patients, are a major concern. Interest in the underlying mechanisms of PANoptosis involved in oral diseases is currently increasing. This review explains the definition, characteristics, regulatory mechanisms of PANoptosis and its potential relationship with oral di-seases, aiming to offer possible solutions for the detection, prevention, and treatment of oral diseases.

Key words: programmed cell death, PANoptosis, PANoptosome, oral disease

中图分类号: 

  • R780.2

图1

泛凋亡的分子调控机制不同的刺激物能诱导泛凋亡复合体的组装，进而诱导泛凋亡的发生。IAV：influenza A virus，甲型流感病毒；C. albicans：Candida albicans，白色念珠菌；A. fumigatus：Aspergillus fumigatus，烟曲霉；HSV-1：herpes simplex virus type 1，单纯疱疹病毒1；F. novicida：Francisella novicida，新弗朗西丝菌；Yersinia：耶尔森菌；Heme：血红素；PAMPs：pathogen-associated molecular patterns，病原相关分子模式；TLR：Toll-like receptor，Toll样受体；TAK1：transforming growth factor-β-activated kinase 1，转化生长因子β活化激酶1；ADAR1：adenosine deaminase acting on RNA 1，作用于RNA 1的腺苷脱氨酶；CASP：caspase（Created with BioGDP.com）。"

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